Enhanced Osteogenic Differentiation of hMSCs Using BMP@ZIF-8-Loaded GelMA Nanocomposite Hydrogels with Controlled BMP-2 Release
ACS Omega,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Hydrogels
are
highly
versatile
materials
with
immense
potential
for
tissue
engineering
and
regenerative
medicine
owing
to
their
biocompatibility,
tunable
mechanical
properties,
ability
mimic
the
natural
extracellular
matrix.
Their
3D
porous
structure
allows
encapsulation
delivery
of
bioactive
molecules,
making
them
ideal
candidates
drug
systems.
In
repair,
particularly
bone
regeneration,
hydrogels
can
serve
as
carriers
that
release
therapeutic
agents
in
a
controlled
manner,
thus
enhancing
healing
process.
Zeolitic
Imidazolate
Framework-8
(ZIF-8)
nanoparticles
recombinant
human
Bone
Morphogenetic
Protein
(rhBMP-2)
molecules
were
incorporated
solely
(ZIF@GelMA)
or
association
(BMP@ZIF@GelMA)
into
gelatin
modified
by
methacryloyl
hydrogel
(GelMA)
investigate
its
physical
osteogenic
properties.
characterized
Scanning
Electron
Microscopy
rheological
tests.
We
analyzed
degradation
BSA
profile
BMP@ZIF@GelMA
samples
throughout
0,
1,
3,
7,
14,
28
days.
Cell
adhesion
formation
markers
hydrogel-encapsulated
dental
pulp
cells
using
immunocytochemistry
molecular
analysis.
ZIF@GelMA
exhibited
viscoelastic
increased
storage
modulus
when
rhBMP2
was
present.
BSA@ZIF@GelMA
showed
balanced
rate
BSA.
The
upregulated
expression
cell
genes,
BMP-2
introduced,
levels
remarkably
elevated.
presents
several
favorable
factors
promote
cellular
encouraging
further
prospects
advanced
applications
repair.
Язык: Английский
Knowledge landscape of macrophage research in liver fibrosis: a bibliometric review of the literature from WoSCC
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 8, 2025
Recent
insights
into
the
immune
response
in
fibrosis
have
provided
valuable
perspectives
for
treatment
of
liver
fibrosis.
Macrophages,
as
most
abundant
cells
liver,
are
key
drivers
They
extensively
involved
tissue
damage,
chronic
inflammation,
and
progression
regression
This
study
aims
to
conduct
a
bibliometric
analysis
literature
review
on
mechanisms
by
which
macrophages
contribute
Specifically,
we
analyzed
dataset
comprising
1,312
papers
from
59
countries,
1,872
institutions,
9,784
authors.
Keyword
co-occurrence
identified
research
hotspots,
including
role
macrophage
subtypes
obesity-related
metabolic
disorders,
crosstalk
between
hepatic
stellate
through
mechanoimmunology,
emerging
strategies
modulation
targeting
promote
regeneration,
new
discoveries
regarding
with
other
cells.
In
conclusion,
this
provides
visual
current
landscape,
trends
field
fibrosis,
discusses
future
directions
further
exploration
area.
Язык: Английский