Nanolevel Immunomodulators in Sepsis: Novel Roles, Current Perspectives, and Future Directions DOI Creative Commons
Liangkang Lin,

Hongbo Liu,

Dingshan Zhang

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 12529 - 12556

Опубликована: Ноя. 1, 2024

Sepsis represents a profound challenge in critical care, characterized by severe systemic inflammatory response which can lead to multi-organ failure and death. The intricate pathophysiology of sepsis involves an overwhelming immune reaction that disrupts normal host defense mechanisms, necessitating innovative approaches modulation. Nanoscale immunomodulators, with their precision targeting controlled release capabilities, have emerged as potent solution recalibrate responses sepsis. This review explores the recent advancements nanotechnology for management, emphasizing integration nanoparticulate systems modulate function pathways. Discussions detail development system, distinct triggered sepsis, scientific principles underpinning nanoscale immunomodulation, including specific mechanisms delivery systems. highlights nanoformulation designs aimed at enhancing bioavailability, stability, therapeutic efficacy, shows promise clinical settings modulating key Ultimately, this synthesizes current state knowledge projects future directions research, underscoring transformative potential nanolevel immunomodulators treatment through technologies strategies.

Язык: Английский

Nanolevel Immunomodulators in Sepsis: Novel Roles, Current Perspectives, and Future Directions DOI Creative Commons
Liangkang Lin,

Hongbo Liu,

Dingshan Zhang

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 12529 - 12556

Опубликована: Ноя. 1, 2024

Sepsis represents a profound challenge in critical care, characterized by severe systemic inflammatory response which can lead to multi-organ failure and death. The intricate pathophysiology of sepsis involves an overwhelming immune reaction that disrupts normal host defense mechanisms, necessitating innovative approaches modulation. Nanoscale immunomodulators, with their precision targeting controlled release capabilities, have emerged as potent solution recalibrate responses sepsis. This review explores the recent advancements nanotechnology for management, emphasizing integration nanoparticulate systems modulate function pathways. Discussions detail development system, distinct triggered sepsis, scientific principles underpinning nanoscale immunomodulation, including specific mechanisms delivery systems. highlights nanoformulation designs aimed at enhancing bioavailability, stability, therapeutic efficacy, shows promise clinical settings modulating key Ultimately, this synthesizes current state knowledge projects future directions research, underscoring transformative potential nanolevel immunomodulators treatment through technologies strategies.

Язык: Английский

Процитировано

1