New Rat Model Mimicking Sacrocolpopexy for POP Treatment and Biomaterials Testing via Unilateral Presacral Suspension
International Urogynecology Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Introduction
and
Hypothesis
Pelvic
organ
prolapse
(POP)
impacts
women’s
health
quality
of
life.
Post-surgery
complications
can
be
severe.
This
study
uses
rat
models
to
replicate
sacrocolpopexy
test
materials
for
pelvic
support,
verifying
the
4-week
postoperative
mortality
rate,
mechanical
properties
mesh
tissue,
collagen
content.
Methods
Twenty-one
12-week-old
female
Wistar
rats
were
used.
Eighteen
subjected
POP
induction
by
cervical
suction
constant
traction.
One
week
after
modeling,
18
prolapsed
underwent
unilateral
presacral
suspension
(UPS)
surgery
with
polycaprolactone
(PCL)
scaffolds,
decellularized
porcine
small
intestinal
submucosa
(SIS)
or
polypropylene
(PP)
meshes
(
n
=
6
each).
UPS
compared
normal
3).
After
4
weeks,
conditions
recorded.
The
then
euthanized
biomechanical
testing
analysis.
Ultimate
load
(N)
was
defined
as
highest
before
failure
target
sample.
Results
procedure
requires
42.9
±
4.5
min
no
deaths
over
weeks.
SIS
stiffest
(14.53
0.86
N),
followed
PP
(8.43
0.40
PCL
least
stiff
(0.66
0.05
N).
ultimate
complex
increased
1.71
0.41
N
p
0.0120),
but
showed
significant
difference
from
parametrial
fascia
(1.25
0.85
N)
uterosacral
ligament
decreased
5.99
0.37
N,
still
higher
than
native
tissue.
complex’s
(10.02
1.80
alone.
ratio
(48.11
9.88%)
closest
that
(36.66
11.64%),
whereas
complexes
had
significantly
ratios
USL.
Conclusions
Unilateral
mimics
classical
human
in
rats.
First,
this
investigate
floor
tissues
at
cellular
level
correcting
POP.
Second,
it
used
validate
new
surgical
treatment
POP,
including
not
limited
foreign
body
reactions
surrounding
tissues,
absorption
time,
etc.
Third,
biological
mechanisms
exposure.
Язык: Английский
Evaluating Electrospun Polycaprolactone Fibers for Blood‐Contacting Applications
Biopolymers,
Год журнала:
2025,
Номер
116(2)
Опубликована: Янв. 22, 2025
ABSTRACT
When
the
kidneys
are
injured,
uremic
toxins
(UTXs)
accumulate
in
body,
affecting
other
tissues
and
causing
a
loss
of
essential
body
functions.
This
study
investigated
adsorption
blood
plasma‐laden
UTXs
on
surface
PCL
fibers
to
assess
their
potential
as
an
alternative
membrane
dialysis
materials.
Using
plasma
containing
26
at
concentration
similar
that
found
end‐stage
kidney
disease
patients,
we
analyzed
adsorbed
proteins
examined
clot
formation
normal
toxin‐treated
presence
fibers.
Our
findings
revealed
significantly
increased
fiber
meshes,
without
leading
formation.
suggests
lack
enzymatic
activation
despite
higher
protein
adsorption.
Additionally,
our
indicates
unmodified
surfaces
have
trigger
strong
humoral
immune
response,
underscoring
importance
understanding
these
interactions
for
development
personalized
treatment
approaches
patients
with
failure.
Язык: Английский
A semi-transparent strong biomimetic wound healing material: zinc oxide and sodium alginate based bi-layer nanofiber membrane
Advanced Composites and Hybrid Materials,
Год журнала:
2025,
Номер
8(2)
Опубликована: Фев. 20, 2025
Язык: Английский
Self-assembled Janus structure nanofiber membranes for skin wound healing: Synergistic Photothermal and Chemical Antibacterial Strategies
Colloids and Surfaces A Physicochemical and Engineering Aspects,
Год журнала:
2025,
Номер
unknown, С. 136921 - 136921
Опубликована: Апрель 1, 2025
Язык: Английский
Construction and Performance Study of a Janus Dressing with Sustainable Drainage Function
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 28, 2025
In
the
field
of
wound
exudate
management,
Janus
dressings
with
unidirectional
fluid
transport
capabilities
have
garnered
extensive
attention.
However,
hydrophilic
layer
tends
to
be
saturated
during
application,
which
often
leads
significant
declines
in
drainage
efficiency.
To
address
this
issue,
study
constructed
a
dressing
hydrophilic-hydrophobic
wettability
gradient
that
could
continuously
evaporate
layer.
The
nanofibers
poly(vinyl
alcohol)-MXene
(PVA-MXene)
were
deposited
onto
hydrophobic
nanofiber
polyurethane-MXene
(PU-MXene)
by
sequential
electrospinning
form
asymmetric
wettability.
can
enable
from
bed
effectively
prevent
rewetting
expelled
biological
fluid.
incorporation
MXene
endows
photothermal
responsiveness,
allowing
it
expel
at
stable
evaporation
rate
and
maintain
moisture-unsaturated
state.
addition,
effect
imparts
antibacterial
activity
infections.
application
using
rat
infection
model
under
NIR
irradiation,
demonstrated
anti-inflammatory
effects,
promoted
collagen
deposition
angiogenesis,
thus
significantly
accelerated
healing
process.
Our
offered
an
innovative
approach
development
structure
provided
effective
solution
for
management.
Язык: Английский