Ferritin/Ferroportin-Regulating Nanoparticles Boosting Intracellular Free Iron for Enhanced Ferrotherapy DOI

Junsheng Zhao,

Yanzhao Yin,

Mengxiao Liu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Ferroptosis therapy efficacy of cancers suffers from relatively low concentrations intracellular free iron ions due to the efficient regulation through storage in ferritin and efflux via ferroportin (FPN). In this study, a ferritin/ferroportin-hijacking nanoplatform (Fe3O4-ART@MM-Hep) containing artemisinin (ART) hepcidin (Hep) is fabricated boost induce reactive oxygen species (ROS) storm. Once tumor site reached, targeted binds FPN triggers internalization degradation FPN, blocking ions. Meanwhile, induces lysosomal ferritin, liberating endogenous iron. Combined with exogenous supplemented by Fe3O4, facilities generation ROS. What's more, released Fe2+ catalyzes generate carbon-centered radicals, further enhancing killing ability. All above strategies trigger an ROS storm cells indicate promising platform for high-performance ferrotherapy.

Язык: Английский

Ferritin/Ferroportin-Regulating Nanoparticles Boosting Intracellular Free Iron for Enhanced Ferrotherapy DOI

Junsheng Zhao,

Yanzhao Yin,

Mengxiao Liu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Ferroptosis therapy efficacy of cancers suffers from relatively low concentrations intracellular free iron ions due to the efficient regulation through storage in ferritin and efflux via ferroportin (FPN). In this study, a ferritin/ferroportin-hijacking nanoplatform (Fe3O4-ART@MM-Hep) containing artemisinin (ART) hepcidin (Hep) is fabricated boost induce reactive oxygen species (ROS) storm. Once tumor site reached, targeted binds FPN triggers internalization degradation FPN, blocking ions. Meanwhile, induces lysosomal ferritin, liberating endogenous iron. Combined with exogenous supplemented by Fe3O4, facilities generation ROS. What's more, released Fe2+ catalyzes generate carbon-centered radicals, further enhancing killing ability. All above strategies trigger an ROS storm cells indicate promising platform for high-performance ferrotherapy.

Язык: Английский

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