Recent progresses in the development of hyaluronic acid-based nanosystems for tumor-targeted drug delivery and cancer imaging

Journal of Pharmaceutical Investigation, Год журнала: 2019, Номер 50(2), С. 115 - 129

Опубликована: Май 3, 2019

Язык: Английский

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Small Peptide Ligands for Targeting EGFR in Triple Negative Breast Cancer Cells

Scientific Reports, Год журнала: 2019, Номер 9(1)

Опубликована: Фев. 25, 2019

Abstract The efficacy of chemotherapy for cancer treatment can be increased by targeted drug delivery to the cells. This is particularly important triple negative breast (TNBC) which a major form treatment. Here we designed and screened library 30 peptides starting with previously reported epidermal growth factor receptor (EGFR) targeting peptide GE11 (YHWYGYTPQNVI). A direct array-whole cell binding assay, where are conjugated cellulose membrane, was used identify four enhanced TNBC Next, were synthesized as FITC-labelled soluble study their uptake cells using flow cytometry. results showed that analogue 22 had several fold higher compared lead GE11. specific confirmed competition experiment pure EGF protein. Further, dose dependent MDA-MB-231 (10 5 ) saturating at around 2 μM concentration. Thus, promising EGFR directly chemotherapeutic or nanoparticles enhance

Язык: Английский

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Emerging targeted drug delivery strategies toward ovarian cancer

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 178, С. 113969 - 113969

Опубликована: Сен. 9, 2021

Язык: Английский

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Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(3), С. 389 - 389

Опубликована: Фев. 23, 2023

The innovative development of nanomedicine has promised effective treatment options compared to the standard therapeutics for cancer therapy. However, efficiency EPR-targeted nanodrugs is not always pleasing as it strongly prejudiced by heterogeneity enhanced permeability and retention effect (EPR). Targeting dynamics EPR improvement therapeutic effects nanotherapeutics using enhancers a vital approach developing Inadequate data on efficacy in humans hampers clinical translation drugs. Molecular targeting, physical amendment, or physiological renovation tumor microenvironment (TME) are crucial approaches improving effect. Advanced imaging technologies visualization EPR-induced distribution tumors, use better animal models, necessary enhance This review discusses strategies effect-based drug delivery therapy diagnosis effects. effort studying beneficial, some advanced nanomedicine-based EPR-enhancing currently undergoing trials, which may be helpful improve clinics.

Язык: Английский

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A review of recent developments of metal–organic frameworks as combined biomedical platforms over the past decade

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 316, С. 102908 - 102908

Опубликована: Апрель 25, 2023

Язык: Английский

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