Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Advanced Functional Materials, Год журнала: 2021, Номер 31(21)

Опубликована: Март 8, 2021

Abstract Bone tissue engineering (BTE) is a rapidly growing field aiming to create biofunctional that can integrate and degrade in vivo treat diseased or damaged tissue. It has become evident scaffold fabrication techniques are very important dictating the final structural, mechanical properties, biological response of implanted biomaterials. A comprehensive review current accomplishments on techniques, their structure, function properties for BTE provided herein. Different types biomaterials ranging from inorganic natural synthetic polymers related composites processing presented. Emergent scaffolding such as electrospinning, freeze‐drying, bioprinting, decellularization also discussed. Strategies improve vascularization potential immunomodulation, which considered grand challenge scaffolding,

Язык: Английский

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Additive manufacturing of structural materials

Materials Science and Engineering R Reports, Год журнала: 2021, Номер 145, С. 100596 - 100596

Опубликована: Апрель 2, 2021

Additive manufacturing (AM), also known as three-dimensional (3D) printing, has boomed over the last 30 years, and its use accelerated during 5 years. AM is a materials-oriented technology, printing resolution versus scalability/speed trade-off exists among various types of materials, including polymers, metals, ceramics, glasses, composite materials. Four-dimensional (4D) together with versatile transformation systems, drives researchers to achieve utilize high dimensional AM. Multiple perspectives structural materials have been raised illustrated in this review, multi-material (MMa-AM), multi-modulus (MMo-AM), multi-scale (MSc-AM), multi-system (MSy-AM), multi-dimensional (MD-AM), multi-function (MF-AM). The rapid tremendous development methods offers great potential for applications, such aerospace field, biomedical electronic devices, nuclear industry, flexible wearable soft sensors, actuators, robotics, jewelry art decorations, land transportation, underwater porous structures.

Язык: Английский

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Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics

Bioactive Materials, Год журнала: 2021, Номер 8, С. 267 - 295

Опубликована: Июль 6, 2021

Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules cells. Among others, methacrylated gelatin (GelMA) has become a representative hydrogel formulation, finding various biomedical applications. Recent efforts on GelMA-based have been devoted to combining them with bioactive functional nanomaterials, aiming provide enhanced physicochemical biological properties GelMA. The benefits this approach multiple: i) reinforcing mechanical properties, ii) modulating viscoelastic property allow printability bio-inks, iii) rendering electrical/magnetic produce electro-/magneto-active the specific tissues (e.g., muscle, nerve), iv) providing stimuli-responsiveness actively deliver molecules, v) endowing capacity in process antioxidant effects). nanomaterial-combined GelMA shown significantly extraordinary behaviors (bone, skin, cardiac, nerve) that rarely observable Here we systematically review these recent nanomaterials-combined considered next-generation multifunctional therapeutics. approaches used can also apply other existing polymeric systems.

Язык: Английский

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Bioprinting 101: Design, Fabrication, and Evaluation of Cell-Laden 3D Bioprinted Scaffolds

Tissue Engineering Part A, Год журнала: 2020, Номер 26(5-6), С. 318 - 338

Опубликована: Фев. 21, 2020

3D bioprinting is an additive manufacturing technique that recapitulates the native architecture of tissues. This accomplished through precise deposition cell-containing bioinks. The spatiotemporal control over bioink permits for improved communication between cells and extracellular matrix, facilitates fabrication anatomically physiologically relevant structures. physiochemical properties bioinks, before after crosslinking, are crucial complex tissue Specifically, rheological bioinks determines printability, structural fidelity, cell viability during printing process, whereas postcrosslinking critical their mechanical integrity, physiological stability, survival, functions. In this review, we critically evaluate design criteria, specifically extrusion-based techniques, to fabricate constructs. effects various processing parameters on biophysical biochemical characteristics discussed. Furthermore, emerging trends future directions in area also highlighted. Graphical abstract [Figure: see text] Impact statement Extrusion-based approach fabricating cell-laden engineered review evaluates criteria pre- post-printing evaluation approaches described, as well new research field development functional

Язык: Английский

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Additive manufacturing of biomaterials for bone tissue engineering – A critical review of the state of the art and new concepts

Progress in Materials Science, Год журнала: 2022, Номер 130, С. 100963 - 100963

Опубликована: Май 18, 2022

Язык: Английский

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3D bioprinting: current status and trends—a guide to the literature and industrial practice

Bio-Design and Manufacturing, Год журнала: 2021, Номер 5(1), С. 14 - 42

Опубликована: Дек. 2, 2021

Abstract The multidisciplinary research field of bioprinting combines additive manufacturing, biology and material sciences to create bioconstructs with three-dimensional architectures mimicking natural living tissues. high interest in the possibility reproducing biological tissues organs is further boosted by ever-increasing need for personalized medicine, thus allowing establish itself biomedical research, attracting extensive efforts from companies, universities, institutes alike. In this context, paper proposes a scientometric analysis critical review current literature industrial landscape provide clear overview its fast-changing complex position. scientific patenting results 2000–2020 are reviewed critically analyzed retrieving 9314 papers 309 international patents order draw picture terms top countries, institutions, journals, authors topics, identifying technology hubs worldwide. This offers guide researchers interested or those who simply want understand emerging trends manufacturing 3D bioprinting. Graphic abstract

Язык: Английский

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Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare

Progress in Materials Science, Год журнала: 2023, Номер 134, С. 101072 - 101072

Опубликована: Янв. 16, 2023

Язык: Английский

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A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting Applications

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(12), С. 6564 - 6564

Опубликована: Июнь 12, 2022

Three-dimensional (3D) bioprinting is an innovative technology in the biomedical field, allowing fabrication of living constructs through approach layer-by-layer deposition cell-laden inks, so-called bioinks. An ideal bioink should possess proper mechanical, rheological, chemical, and biological characteristics to ensure high cell viability production tissue with dimensional stability shape fidelity. Among several types bioinks, hydrogels are extremely appealing as they have many similarities extracellular matrix, providing a highly hydrated environment for proliferation tunability terms mechanical rheological properties. Hydrogels derived from natural polymers, polysaccharides, particular, excellent platform mimic given their low cytotoxicity, hydrophilicity, diversity structures. In fact, polysaccharide-based trendy materials 3D since abundant combine adequate physicochemical biomimetic features development novel Thus, this review portrays most relevant advances hydrogel bioinks bioprinting, focusing on last five years, emphasis properties, advantages, limitations, considering polysaccharide families classified according source, namely seaweed, higher plants, microbial, animal (particularly crustaceans) origin.

Язык: Английский

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Engineering Large‐Scale Self‐Mineralizing Bone Organoids with Bone Matrix‐Inspired Hydroxyapatite Hybrid Bioinks

Advanced Materials, Год журнала: 2024, Номер 36(30)

Опубликована: Апрель 20, 2024

Abstract Addressing large bone defects remains a significant challenge owing to the inherent limitations in self‐healing capabilities, resulting prolonged recovery and suboptimal regeneration. Although current clinical solutions are available, they have notable shortcomings, necessitating more efficacious approaches Organoids derived from stem cells show great potential this field; however, development of organoids has been hindered by specific demands, including need for robust mechanical support provided scaffolds hybrid extracellular matrices (ECM). In context, bioprinting technologies emerged as powerful means replicating complex architecture tissue. The research focused on fabrication highly intricate ECM analog using novel bioink composed gelatin methacrylate/alginate methacrylate/hydroxyapatite (GelMA/AlgMA/HAP). Bioprinted facilitate long‐term cultivation progressive maturation extensive bioprinted organoids, foster multicellular differentiation, offer valuable insights into initial stages formation. intrinsic self‐mineralizing quality closely emulates properties natural bone, empowering with enhanced repair both vitro vivo applications. This trailblazing investigation propels field tissue engineering holds promise its translation practical

Язык: Английский

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Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Biomacromolecules, Год журнала: 2024, Номер 25(4), С. 2156 - 2221

Опубликована: Март 20, 2024

Tissue engineering for injured tissue replacement and regeneration has been a subject of investigation over the last 30 years, there considerable interest in using additive manufacturing to achieve these goals. Despite such efforts, many key questions remain unanswered, particularly area biomaterial selection applications as well quantitative understanding process science. The strategic utilization biological macromolecules provides versatile approach meet diverse requirements 3D printing, printability, buildability, biocompatibility. These molecules play pivotal role both physical chemical cross-linking processes throughout biofabrication, contributing significantly overall success printing process. Among several bioprintable materials, gelatin methacryloyl (GelMA) widely utilized applications, with some degree success. In this context, review will discuss bioengineering approaches identify gelation strategies that are appropriate control rheology, buildability inks. This focus on GelMA structural (scaffold) different tissues potential carrier vehicle transport living cells their maintenance viability physiological system. Recognizing importance printability toward shape fidelity biophysical properties, major qualitative impact factors, including microrheological, viscoelastic, gelation, shear thinning properties inks, parameters, particular, reference extrusion GelMA-based Specifically, we emphasize possibilities regulate mechanical, swelling, biodegradation, cellular functionalities bio(material) by hybridization techniques, synthetic natural biopolymers, inorganic nanofillers, microcarriers. At close, possibility integration experimental data sets artificial intelligence/machine learning is emphasized predict fidelity, or inks clinically relevant tissues.

Язык: Английский

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