Unleashing the power of polymeric nanoparticles — Creative triumph against antibiotic resistance: A review
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
278, С. 134977 - 134977
Опубликована: Авг. 24, 2024
Antibiotic
resistance
(ABR)
poses
a
universal
concern
owing
to
the
widespread
use
of
antibiotics
in
various
sectors.
Nanotechnology
emerges
as
promising
solution
combat
ABR,
offering
targeted
drug
delivery,
enhanced
bioavailability,
reduced
toxicity,
and
stability.
This
comprehensive
review
explores
concepts
antibiotic
resistance,
its
mechanisms,
multifaceted
approaches
ABR.
The
provides
an
in-depth
exploration
polymeric
nanoparticles
advanced
delivery
systems,
focusing
on
strategies
for
targeting
microbial
infections
contributing
fight
against
Nanoparticles
revolutionize
antimicrobial
approaches,
emphasizing
passive
active
targeting.
role
molecules,
including
small
peptides,
proteins,
carbohydrates,
stimuli-responsive
is
being
explored
recent
research
works.
complex
comprehension
mechanisms
ABR
strategic
nanotechnology
present
avenue
advancing
tactics,
ensuring
treatment
efficacy,
minimizing
toxic
effects,
mitigating
development
Polymeric
nanoparticles,
derived
from
natural
or
synthetic
polymers,
are
crucial
overcoming
Natural
polymers
like
chitosan
alginate
exhibit
inherent
antibacterial
properties,
while
such
polylactic
acid
(PLA),
polyethylene
glycol
(PEG),
polycaprolactone
(PCL)
can
be
engineered
specific
effects.
study
valuable
source
information
researchers,
healthcare
professionals,
policymakers
engaged
urgent
quest
overcome
Язык: Английский
Green synthesis of peroxidase mimetic Cobalt ferrite nanoparticles for antioxidant, anti-bacterial and drug delivery studies
Materials Today Chemistry,
Год журнала:
2025,
Номер
43, С. 102502 - 102502
Опубликована: Янв. 1, 2025
Язык: Английский
Synthesis of viral-like lignin/Ag nanoparticles with spiky surfaces for antibacterial and antioxidant applications
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
305, С. 141034 - 141034
Опубликована: Фев. 13, 2025
Язык: Английский
Design of Short Peptides for the Reduction of Silver Ions and Stabilization of Nanocomposites in Combating Bacterial Infections
ChemBioChem,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Combating
bacterial
infections
has
become
a
formidable
challenge
in
healthcare
due
to
the
rise
of
antibiotic
resistance.
Recently,
short
peptide-based
nanobiomaterials,
assembled
through
silver
metal
and
peptide
building
blocks,
have
emerged
as
promising
agents
for
treating
resistant
infections.
In
this
minireview,
recent
advances
silver-peptide
nanocomposites
are
highlighted,
both
with
without
assistance
UV
or
sunlight,
antibacterial
applications.
The
chemical
design
biomolecules
such
amphiphilic
peptides,
amino
acids,
oligopeptides
plays
crucial
role
reduction,
stabilization,
biocompatibility
nanocomposites.
Noncovalent
interactions
involved
formation
explored
context
structure-function
relationship.
activities
underlying
mechanisms,
which
depend
on
specific
also
reviewed.
Finally,
conclusion
outlook
provide
insights
into
novel
blocks
development
enhanced
activities.
Язык: Английский
Assessing the Toxicity of Terpene- and Amino Acid-Based Natural Deep Eutectic Solvents
Chemical Research in Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Over
the
past
decade,
there
has
been
a
significant
increase
in
discovery
of
greener
solvents
for
industrial
applications.
In
this
context,
deep
eutectic
(DESs)
have
emerged
as
promising
candidates
across
various
sectors,
including
biomass
conversion,
paper
and
pulp,
pharmaceuticals,
textiles.
A
new
class
DESs,
known
natural
(NADESs),
is
derived
from
chemicals
expected
to
be
more
environmentally
friendly.
However,
research
into
environmental
impact
toxicity
NADESs
still
limited.
Given
broad
applications
DESs
urgent
need
sustainable
alternatives,
studying
their
crucial.
our
current
study,
we
focused
on
formulated
menthol,
thymol,
amino
acid.
We
assessed
different
cell
lines
using
standard
biochemical
assays.
Remarkably,
findings
also
indicate
that
these
exhibit
low
HaCaT
line
mice
blood
sample.
found
all
tested
shown
better
antimicrobial
property
values
compared
individual
components
NADESs,
indicating
importance
NADES
formulation
Among
menthol:thymol
(1:1)
showed
best
antibacterial
properties.
These
results
hold
implications
development
applications,
suggesting
path
forward
adoption
safer
solvents.
Язык: Английский
Novel green synthesis of cluster AgNPs by reduction of Silver (I) by vitamin C in presence of alginate surfactant powder in aqueous media: Characteristics and applications
Environmental Nanotechnology Monitoring & Management,
Год журнала:
2024,
Номер
22, С. 100971 - 100971
Опубликована: Дек. 1, 2024
Язык: Английский
Multifunctional silver nanoparticle embedded eri silk cocoon scaffolds against burn wounds-associated infection
RSC Advances,
Год журнала:
2024,
Номер
14(37), С. 26723 - 26737
Опубликована: Янв. 1, 2024
Antimicrobial
wound
dressings
offer
enhanced
efficacy
compared
to
conventional
dressing
platforms
by
limiting
bacterial
infections,
expediting
the
healing
process,
and
creating
a
barrier
against
additional
contamination.
Язык: Английский
Solvent-Induced Lignin Conformation Changes Affect Synthesis and Antibacterial Performance of Silver Nanoparticle
Nanomaterials,
Год журнала:
2024,
Номер
14(11), С. 957 - 957
Опубликована: Май 30, 2024
The
emergence
of
antibiotic-resistant
bacteria
necessitates
the
development
novel,
sustainable,
and
biocompatible
antibacterial
agents.
This
study
addresses
cytotoxicity
environmental
concerns
associated
with
traditional
silver
nanoparticles
(AgNPs)
by
exploring
lignin,
a
readily
available
renewable
biopolymer,
as
platform
for
AgNPs.
We
present
novel
one-pot
synthesis
method
lignin-based
AgNPs
(AgNPs@AL)
nanocomposites,
achieving
rapid
within
5
min.
utilizes
various
organic
solvents,
demonstrating
remarkable
adaptability
to
wide
range
lignin-dissolving
systems.
Characterization
reveals
uniform
AgNP
size
distribution
morphology
influenced
chosen
solvent.
suggests
potential
incorporating
lignin-loaded
drugs
alongside
AgNPs,
enabling
combined
therapy
in
single
nanocomposite.
Antibacterial
assays
demonstrate
exceptional
efficacy
against
both
Gram-negative
Gram-positive
bacteria,
gamma-valerolactone
(GVL)-assisted
synthesized
exhibiting
most
potent
effect.
Mechanistic
studies
suggest
combination
factors
contributes
activity,
including
direct
membrane
damage
caused
sustained
ion
release,
ultimately
leading
bacterial
cell
death.
work
presents
straightforward,
adaptable,
approach
synthesizing
AgNPs@AL
nanocomposites
outstanding
activity.
These
findings
offer
promising
sustainable
alternative
antibiotics,
contributing
fight
antibiotic
resistance
while
minimizing
impact.
Язык: Английский