Magnetic Micro/nanorobots in Cancer Theranostics: From Designed Fabrication to Diverse Applications

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Cancer poses a substantial threat and serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge promising therapeutic candidates that provide alternative strategies MNR is kind human-made machine micro- or nanosized, reasonably designed, performs command tasks through self-actuated externally controlled propulsion mechanisms, which can be potentially applied in theranostics. Here, this review first introduces components constitute typical MNR, including body part, control function sensing part. Subsequently, elucidates representative fabrication methods construct MNRs from top-down approaches bottom-up approaches, covering injection molding, self-rolling, melt electrospinning writing, deposition, biotemplate method, lithography, assembling, 3D printing, chemical synthesis. Furthermore, focuses on multiple applications facing diagnosis treatment, encompassing imaging, quantification, drug release, synergy with therapies, cell manipulation, surgical assistance. Then, systematically elaborates biocompatibility biosafety MNRs. Finally, challenges faced by are discussed alongside future research directions. This intended scientific guidance may improve comprehension cognition theranostics platform MNRs, promoting prospering practical application development

Язык: Английский

---

Multifunctional nano/micromotors: design, characterization, and potential applications in radiation attenuation

Radiation effects and defects in solids, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Фев. 20, 2025

---

Janus Polymeric Giant Vesicles on Demand: A Predictive Phase Separation Approach for Efficient Formation

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Janus particles, with their intrinsic asymmetry, are attracting major interest in various applications, including emulsion stabilization, micro/nanomotors, imaging, and drug delivery. In this context, polymersomes particularly attractive for synthetic cell development delivery systems. While they can be achieved by inducing a phase separation within membrane, fabrication method remains largely empirical. Here, we propose rational approach, using Flory–Huggins theory, to predict the self-assembly of amphiphilic block copolymers into asymmetric polymersomes. Our predictions experimentally validated forming highly stable giant unilamellar vesicles (JGUVs) remarkable yield exceeding 90% obtained from electroformation biocompatible copolymers. We also present general diagram correlating mixing energy polymersome morphology, offering valuable tool JGUV design. These extruded achieve quasi-monodisperse while maintaining Janus-like paving way functionalization use as active carriers.

Язык: Английский

---

Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine

Applied Materials Today, Год журнала: 2025, Номер 43, С. 102673 - 102673

Опубликована: Март 13, 2025

---

Recyclable and well-dispersed Fe3O4@SiO2@polydopamine@Ag nanocomposite with enhanced photothermal effect for synergistic antibacteria effect

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161994 - 161994

Опубликована: Март 1, 2025

Язык: Английский

---