Ru‐Ph Nanozyme‐Based Hydrogels for Tumor Chemodynamic Therapy by Enhancing Enzyme Catalytic Efficiency Through Multiple Pathways DOI
Min Xiao, Yiqun Zhang,

Jianghao Xing

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)

Опубликована: Дек. 23, 2024

Abstract The discovery of nanozymes has opened new possibilities for tumor therapy. However, their reliance on the microenvironment and limited catalytic efficiency hinder broader applications. In this study, ruthenium‐phenanthroline nanoparticles (Ru‐Phs) are synthesized by combining ruthenium with phenanthroline subsequently coloaded proton pump inhibitor (PPI) pantoprazole into sodium alginate (ALG) to form a Ru‐Phs‐PPI‐ALG hydrogel in situ This demonstrates excellent chemodynamic properties, forming gel within tissues gradually releasing Ru‐Phs, which generates highly toxic reactive oxygen species (ROS) via peroxidase‐like (POD‐like) activity. inclusion PPI reduced intracellular pH cells, accelerating Fenton reaction ROS accumulation. Additionally, high photothermal conversion enables heat generation under near‐infrared (NIR) irradiation, not only disrupts cell structures but also further enhances POD‐like activity Ru‐Phs. effectively killed 4T1 cells vitro, transcriptomic analysis confirms its potent efficacy. vivo experiments demonstrate significant ablation biocompatibility. multipathway strategy increase enzyme improve effects provides promising approach advancing nanozyme applications

Язык: Английский

Nanozymes meet hydrogels: Fabrication, progressive applications, and perspectives DOI

Manyan Qiu,

Chaoxin Man, Qianyu Zhao

и другие.

Advances in Colloid and Interface Science, Год журнала: 2025, Номер 338, С. 103404 - 103404

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

1
RECENT ADVANCEMENTS IN NANOZYME HYDROGEL BASED SYSTEM FOR ENHANCED SENSING APPLICATIONS DOI Creative Commons

Simran Makkar,

Nikita Sarawagi, Nitesh Priyadarshi

и другие.

Biosensors and Bioelectronics X, Год журнала: 2024, Номер unknown, С. 100548 - 100548

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

3
Ru‐Ph Nanozyme‐Based Hydrogels for Tumor Chemodynamic Therapy by Enhancing Enzyme Catalytic Efficiency Through Multiple Pathways DOI
Min Xiao, Yiqun Zhang,

Jianghao Xing

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)

Опубликована: Дек. 23, 2024

Abstract The discovery of nanozymes has opened new possibilities for tumor therapy. However, their reliance on the microenvironment and limited catalytic efficiency hinder broader applications. In this study, ruthenium‐phenanthroline nanoparticles (Ru‐Phs) are synthesized by combining ruthenium with phenanthroline subsequently coloaded proton pump inhibitor (PPI) pantoprazole into sodium alginate (ALG) to form a Ru‐Phs‐PPI‐ALG hydrogel in situ This demonstrates excellent chemodynamic properties, forming gel within tissues gradually releasing Ru‐Phs, which generates highly toxic reactive oxygen species (ROS) via peroxidase‐like (POD‐like) activity. inclusion PPI reduced intracellular pH cells, accelerating Fenton reaction ROS accumulation. Additionally, high photothermal conversion enables heat generation under near‐infrared (NIR) irradiation, not only disrupts cell structures but also further enhances POD‐like activity Ru‐Phs. effectively killed 4T1 cells vitro, transcriptomic analysis confirms its potent efficacy. vivo experiments demonstrate significant ablation biocompatibility. multipathway strategy increase enzyme improve effects provides promising approach advancing nanozyme applications

Язык: Английский

Процитировано

0