Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility bacterial infection. In this study, we developed dual ROS/glucose-responsive quercetin-loaded supramolecular hydrogel (GPQ hydrogel) for treating diabetic wounds. The was fabricated by incorporating quercetin (QUE) into guanosine–phenylboronic acid (GP) network through dynamic borate ester bonds. Structural characterization revealed the formation of typical G-quadruplex structure in GPQ hydrogel. responsiveness ROS glucose enabled controlled release QUE, effectively addressing abnormal microenvironment diabetes. vitro studies demonstrated excellent antibacterial, antioxidant, anti-inflammatory, pro-angiogenic properties Furthermore, vivo study using full-thickness model streptozotocin-induced rats showed that significantly accelerated closure, enhanced re-epithelialization collagen deposition, promoted compared control GP groups. Immunofluorescence analysis confirmed superior antioxidant effects microenvironment. This presents promising multifunctional biomaterial managing

Язык: Английский

Thermosensitive, injectable, antibacterial glabridin liposome/chitosan dual network hydrogel for diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 290, С. 138966 - 138966

Опубликована: Дек. 19, 2024

Язык: Английский