Neuropharmacology of Fisetin as a Senotherapeutic Agent: Investigating Its Role in Neurodegeneration and Brain Aging DOI

Sidra Javaid,

Aamir Memon,

Binish Anwar

и другие.

Pakistan Journal of Health Sciences, Год журнала: 2024, Номер unknown, С. 262 - 269

Опубликована: Ноя. 30, 2024

Fisetin, a flavonoid in various fruits and vegetables, has emerged as promising chemotherapeutic agent with potential neuroprotective effects, particularly neurodegeneration brain aging. Objective: To explore the role of fisetin mitigating age-related neuronal damage by targeting oxidative stress, inflammation, cellular senescence, common contributors to neurodegenerative diseases such Alzheimer's Parkinson's. Methods: Following PRISMA guidelines, relevant studies were sourced from ScienceDirect, Google Scholar, PubMed, spanning publications between April 2014 August 2024. One website was also used retrieve studies, i.e., Frontiers. Fisetin's mechanism action includes modulating key pathways, inhibition inflammatory markers, reduction Reactive Oxygen Species (ROS), protection against apoptosis. Results: Studies conducted on animal models human-derived cell lines reveal its improve cognitive function reduce progression disorders. Conclusions: ability selectively target senescent cells, neuroinflammation, enhance synaptic positions it therapeutic for Future research focusing clinical trials dosing optimization crucial establishing viable treatment conditions decline associated

Язык: Английский

Neuropharmacology of Fisetin as a Senotherapeutic Agent: Investigating Its Role in Neurodegeneration and Brain Aging DOI

Sidra Javaid,

Aamir Memon,

Binish Anwar

и другие.

Pakistan Journal of Health Sciences, Год журнала: 2024, Номер unknown, С. 262 - 269

Опубликована: Ноя. 30, 2024

Fisetin, a flavonoid in various fruits and vegetables, has emerged as promising chemotherapeutic agent with potential neuroprotective effects, particularly neurodegeneration brain aging. Objective: To explore the role of fisetin mitigating age-related neuronal damage by targeting oxidative stress, inflammation, cellular senescence, common contributors to neurodegenerative diseases such Alzheimer's Parkinson's. Methods: Following PRISMA guidelines, relevant studies were sourced from ScienceDirect, Google Scholar, PubMed, spanning publications between April 2014 August 2024. One website was also used retrieve studies, i.e., Frontiers. Fisetin's mechanism action includes modulating key pathways, inhibition inflammatory markers, reduction Reactive Oxygen Species (ROS), protection against apoptosis. Results: Studies conducted on animal models human-derived cell lines reveal its improve cognitive function reduce progression disorders. Conclusions: ability selectively target senescent cells, neuroinflammation, enhance synaptic positions it therapeutic for Future research focusing clinical trials dosing optimization crucial establishing viable treatment conditions decline associated

Язык: Английский

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