Transdermal patch based on pressure-sensitive adhesive: the importance of adhesion for efficient drug delivery
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Transdermal
patches
offer
a
unique
advantage
by
providing
extended
therapeutic
benefits
while
maintaining
stable
plasma
drug
concentration.
The
efficacy
and
safety
of
depend
significantly
on
their
ability
to
adhere
the
skin,
feature
influenced
various
external
internal
factors.
review
primarily
focuses
fundamental
aspects
adhesion
in
transdermal
patches,
including
basic
information
about
underlying
principles
adhesion,
delivery,
characteristics
pressure
sensitive
adhesives
(PSAs),
issues,
impact
factors,
strategies
improve
patch
relevant
molecular
mechanisms.
development
with
sufficient
for
consistent
delivery
remains
challenging
task.
Challenges
stem
from
complex
interplay
among
PSAs,
permeation
enhancers,
active
pharmaceutical
ingredients
(APIs),
other
excipients
current
compositions,
further
complicated
variations
arising
dermatological
These
intricacies
impede
effectiveness
patches.
Progress
exploration
new
PSA
polymers,
conjunction
innovative
is
crucial
establishing
an
optimal
equilibrium
between
utilization
rate,
drug-loading,
release,
thus
effectively
addressing
challenges
related
adhesion.
Язык: Английский
Combining ion-pair strategy and chemical enhancers to develop mirtazapine long-acting transdermal patches for depression treatment
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
unknown, С. 106435 - 106435
Опубликована: Ноя. 1, 2024
Язык: Английский
Innovative Long-Acting Bisoprolol Patch: Synergistic Ion-Pair Skin Adsorption for Drug Delivery Control Coupled with Dynamic Modulation of Penetration Enhancers
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
This
study
aims
to
develop
a
sustained
release
patch
for
bisoprolol
(BSP)
address
the
issue
of
blood
pressure
fluctuations
caused
by
traditional
dosing
methods,
ensuring
continuous
drug
and
efficient
utilization.
Long-chain
saturated
fatty
acids
(C6–C12)
were
chosen
as
counterions
precisely
control
BSP's
permeation
rate
in
formulation,
ion-pairing
strategy's
mechanism
delivery
was
thoroughly
investigated.
Molecular
docking
results
revealed
significant
differences
adsorption
capacities
different
ion
pairs
stratum
corneum
(SC)
epidermis,
directly
influencing
their
residence
times
thereby
regulating
passive
diffusion
rate.
Particularly,
BSP-C10
pair
successfully
reduced
one-third
its
baseline.
To
enhance
efficiency
reduce
costs,
chemical
enhancers
(CPEs)
are
typically
added
patches.
In
contrast
static
analyses
based
on
cumulative
permeation,
this
utilized
ATR-FTIR
dynamic
detection
isopropyl
myristate
(IPM)
preferred
enhancer,
studying
disruptive
effects
skin
barrier
during
delivery.
The
observed
that
delivery,
interaction
between
IPM
lipids
follows
U-shaped
trend:
initially
increasing,
then
decreasing,
with
peak
occurring
at
10
h.
Similarly,
displays
comparable
pattern.
addition
CPE
increased
utilization
from
39.8
±
4.31
79.8
7.27%.
strategy
rapidly
initial
phase
subsequent
weakening
disruption,
allowing
dominate
maintain
stable
long-term
therapeutic
effects.
Pharmacokinetic
studies
demonstrated
newly
developed
BSP
maintains
concentrations,
reduces
burst
effects,
increases
bioavailability
84.679%,
doubles
MRT0–t,
halves
Cmax,
significantly
occurrence
fluctuations.
Язык: Английский