Aggregation-Induced Photosensitization of Long-Chain-Substituted Osmium Complexes for Lysosomes Targeting Photodynamic Therapy DOI
Ziyu Zhou, Shuo Li,

Xiuqian Ding

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Photodynamic therapy (PDT) has been demonstrated to be an effective tool for cancer treatment. Seeking organelle-targeting photosensitizers (PSs) with robust reactive oxygen species (ROS) production is extremely in demand. Herein, we propose aggregation-induced photosensitization strategy PDT osmium complexes. We designed and synthesized three complexes (Os-Me, Os-tBu, Os-Nonly) ligands of different alkyl chains. In phosphate-buffered saline solution, the complex Os-Nonly formed a spherical aggregate diameters around 220 nm. The results from ROS assays indicate that showed highest efficiency generating superoxide anions singlet oxygen, demonstrating its role as type I/II photosensitizer. Additionally, specifically targeted lysosomes 4T1 MCF-7 cells, producing sustained efficient manner high phototoxicity (IC50 = 6.999 μM cells), thereby inducing cell death. 4T1-tumor-bearing mice models, effectively inhibited tumor growth minimal impact on normal organs.

Язык: Английский

Aggregation-Induced Photosensitization of Long-Chain-Substituted Osmium Complexes for Lysosomes Targeting Photodynamic Therapy DOI
Ziyu Zhou, Shuo Li,

Xiuqian Ding

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Photodynamic therapy (PDT) has been demonstrated to be an effective tool for cancer treatment. Seeking organelle-targeting photosensitizers (PSs) with robust reactive oxygen species (ROS) production is extremely in demand. Herein, we propose aggregation-induced photosensitization strategy PDT osmium complexes. We designed and synthesized three complexes (Os-Me, Os-tBu, Os-Nonly) ligands of different alkyl chains. In phosphate-buffered saline solution, the complex Os-Nonly formed a spherical aggregate diameters around 220 nm. The results from ROS assays indicate that showed highest efficiency generating superoxide anions singlet oxygen, demonstrating its role as type I/II photosensitizer. Additionally, specifically targeted lysosomes 4T1 MCF-7 cells, producing sustained efficient manner high phototoxicity (IC50 = 6.999 μM cells), thereby inducing cell death. 4T1-tumor-bearing mice models, effectively inhibited tumor growth minimal impact on normal organs.

Язык: Английский

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