Biosensors,
Год журнала:
2024,
Номер
14(10), С. 506 - 506
Опубликована: Окт. 17, 2024
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disorder,
affecting
lives
of
millions
people
worldwide.
Although
mechanism
underlying
PD
pathogenesis
largely
undefined,
increasing
evidence
indicates
that
oxidative
and
nitrosative
stresses
play
a
crucial
role
in
occurrence
development.
Among
them,
stress
has
been
widely
acknowledged,
but
there
relatively
less
attention
given
to
stress,
which
mainly
derived
from
peroxynitrite.
In
present
review,
after
briefly
introducing
background
PD,
we
discuss
physiopathological
function
peroxynitrite
especially
highlight
how
overloaded
involved
pathogenesis.
Then,
summarize
currently
reported
fluorescence
imaging-based
detection
probes.
Moreover,
specifically
emphasize
probes
have
applied
research.
Finally,
propose
perspectives
on
develop
more
applicable
probe
leverage
it
for
theranostics.
Conclusively,
review
broadens
knowledge
pathological
context
sheds
light
utilize
strategies
detection.
Chemical Reviews,
Год журнала:
2024,
Номер
124(16), С. 9225 - 9375
Опубликована: Авг. 13, 2024
Reactive
oxygen
and
nitrogen
species
are
small
reactive
molecules
derived
from
elements
in
the
air─oxygen
nitrogen.
They
produced
biological
systems
to
mediate
fundamental
aspects
of
cellular
signaling
but
must
be
very
tightly
balanced
prevent
indiscriminate
damage
molecules.
Small
molecule
probes
can
transmute
specific
nature
each
into
an
observable
luminescent
signal
(or
even
acoustic
wave)
offer
sensitive
selective
imaging
living
cells
whole
animals.
This
review
focuses
specifically
on
for
superoxide,
hydrogen
peroxide,
hypochlorite,
nitric
oxide,
peroxynitrite
that
provide
a
or
photoacoustic
signal.
Important
background
information
general
photophysical
phenomena,
common
probe
designs,
mechanisms,
modalities
will
provided,
then,
analyte
thoroughly
evaluated.
A
discussion
successes
field
presented,
followed
by
recommendations
improvement
future
outlook
emerging
trends.
Our
objectives
informative,
useful,
thorough
guide
as
well
important
context
compare
ecosystem
chemistries
molecular
scaffolds
has
manifested
within
field.
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 23, 2025
Cancer
is
a
genetic
disorder
caused
by
the
long-term
interaction
of
many
factors,
which
has
become
most
important
factor
to
take
away
human
health;
therefore,
it
essential
develop
more
efficient
and
sensitive
cancer
detection
technology.
This
study
developed
two
polarity
probes
1a
1b
based
on
1,6-naphthyridine
moiety
linked
different
targeting
groups
vinyl
as
π
bridge.
As
solvent
decreased,
emission
wavelength
experienced
blue
shift,
resulting
in
significant
enhance
fluorescence
intensity
135-fold
53-fold,
respectively,
good
linear
relationship
between
Fmax
Δf
was
established
with
high
correlation
coefficients.
Furthermore,
exhibited
large
Stokes
shifts,
photostability,
low
cytotoxicity,
successfully
intracellular
lipid
droplets
mitochondria.
Fluctuation
detected
real-time
changes
Moreover,
probe
capable
monitoring
mitochondrial
during
starvation
or
rapamycin-induced
autophagy.
It
worth
standing
out
could
distinguish
normal
cells
from
cells,
then
also
were
applied
for
imaging
differentiate
tissues
cancerous
tissues,
malignant
tumor
being
15.4-19.9
folds
higher
than
that
5.3-7.2
times
benign
tissues.
Therefore,
this
research
offers
potential
applications
diagnosis.
