One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT DOI
Neha Mehrotra, Kaushik Pal

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 17(1), С. 408 - 418

Опубликована: Дек. 25, 2024

Copper-based sulfides are attractive candidates for NIR I and II responsive photothermal therapy but often suffer from high hydrophobicity, suboptimal conversion, poor biostability biocompatibility. In the present work, a rapid, one-pot synthesis method was developed to obtain Au-doped Cu1.92S (ACSH NDs) dual plasmonic nanodots. ACSH NDs exhibit excellent peroxidase-like catalytic activity pH-responsive •OH radical generation along with efficient glutathione depletion under tumor microenvironment mimicking conditions. Upon exposure NIR-I laser light, demonstrate conversion efficiency of 47.44% as well significant photodynamic effect through singlet oxygen generation. The in situ hyaluronic acid capping endows nanodots highly selective uptake breast cancer cells both vitro vivo. Simultaneous chemodynamic NIR-triggered photothermal/photodynamic activities result synergistic cell death 98% inhibition single-dose mouse model study. Therefore, show remarkable potential single nanoplatform-actuated drug-free multimodal therapy.

Язык: Английский

Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms DOI
Wenqi Wang, Peng Gao,

Hengshuo Gui

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 522, С. 216205 - 216205

Опубликована: Сен. 11, 2024

Язык: Английский

Процитировано

13
Biometallic ions and derivatives: a new direction for cancer immunotherapy DOI Creative Commons
Lin Zhao,

Yajun Gui,

Jing Cai

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 15, 2025

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.

Язык: Английский

Процитировано

1
Reactive Oxygen Species Amplifier Based on Bi2WO6/BP Heterojunction for High Efficiency Radiotherapy Enhancement DOI

Shufen Ren,

Qing Zhang,

Hanping Fu

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Insufficient reactive oxygen species (ROS) generation and radioresistance resulting from the intrinsic features of tumors consistently give rise to unsatisfactory therapeutic outcomes radiotherapy (RT).

Язык: Английский

Процитировано

0
Therapeutic application of nanosystems-based metalloptosis for enhanced tumor radiotherapy DOI

Meili Chen,

Ling Chen,

Kun Mao

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 536, С. 216666 - 216666

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

0
Focus on cuproptosis: Exploring new mechanisms and therapeutic application prospects of cuproptosis regulation DOI Open Access

Donglin Hao,

Wei Luo,

Yongmin Yan

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117182 - 117182

Опубликована: Июль 24, 2024

Cuproptosis is a novel form of regulated cell death, which plays an important role in the physiological and pathological processes human body. Despite increasing research on cuproptosis-related genes (CRGs) their correlation with diseases, pathogenesis diseases remains unclear. Furthermore, there lack reviews emerging technologies for regulating cuproptosis disease treatment. This study delves into copper-induced death mechanism, distinguishing from mechanisms like oxidative stress, glutathione synthesis inhibition, ubiquitin-proteasome system inhibition. Several long-standing mysteries such as Wilson's Menkes may be attributed to occurrence cuproptosis. In addition, we also review detection indicators related cuproptosis, providing targets diagnosis summarize application value tumor therapy better elucidate impact copper thus promote prospects possible strategies substances, ion chelators, carriers, nanomaterials, therapy.

Язык: Английский

Процитировано

3
Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer DOI Creative Commons
Xiangdong Liu, Wanqiu Zhang,

Shaozhong Wei

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 3, 2024

Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, a novel therapeutic methodology, opened up new possibilities for colorectal patients. However, its actual clinical efficacy requires further enhancement. Copper, an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing critical role pathogenesis cancer. Recent studies have revealed that cuproptosis, mode cell death, holds promise to become potential target overcome resistance immunotherapy. This shows substantial combination treatment Conveying copper into tumor cells via nano-drug delivery system induce cuproptosis could offer strategy eliminating drug-resistant vastly improving immunotherapy while ultimately destroy tumors. Moreover, combining induction with other anti-tumor approaches such photothermal therapy, photodynamic chemodynamic therapy enhance effect. review aims illuminate practical significance cuproptosis-inducing nano-drugs immunotherapy, scrutinize current challenges limitations this thereby providing innovative thoughts references advancement cuproptosis-based strategies.

Язык: Английский

Процитировано

1
Cuproptosis in Cancer Therapy: Mechanisms, Therapeutic Application and Future DOI
Jiawei Hu, Junfei Zhu, Tao Chen

и другие.

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Cuproptosis is a regulated form of cell death induced by the accumulation metal ions and closely linked to aspects cellular drug resistance, metabolism, signalling pathways. Due its crucial role in regulating physiological pathological processes, cuproptosis has gained increasing significance as potential target for anticancer development. In this review, we introduce definition provide comprehensive discussion mechanisms cuproptosis. addition, methods detection are summarized, recent advances cancer therapy reviewed, mainly terms elesclomol (ES)-mediated disulfiram (DSF)-mediated cuproptosis, which provided practical value applications. Finally, current challenges future development cuproptosis-mediated discussed. summary, review highlights progress on therapy, offering novel ideas strategies research

Язык: Английский

Процитировано

0
Nanoplatform for synergistic therapy constructed via the co-assembly of a reduction-responsive cholesterol-based block copolymer and a photothermal amphiphile DOI Creative Commons
Lu Yue,

Tiantian Cai,

Juanjuan Gao

и другие.

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101355 - 101355

Опубликована: Ноя. 21, 2024

Язык: Английский

Процитировано

0
One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT DOI
Neha Mehrotra, Kaushik Pal

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 17(1), С. 408 - 418

Опубликована: Дек. 25, 2024

Copper-based sulfides are attractive candidates for NIR I and II responsive photothermal therapy but often suffer from high hydrophobicity, suboptimal conversion, poor biostability biocompatibility. In the present work, a rapid, one-pot synthesis method was developed to obtain Au-doped Cu1.92S (ACSH NDs) dual plasmonic nanodots. ACSH NDs exhibit excellent peroxidase-like catalytic activity pH-responsive •OH radical generation along with efficient glutathione depletion under tumor microenvironment mimicking conditions. Upon exposure NIR-I laser light, demonstrate conversion efficiency of 47.44% as well significant photodynamic effect through singlet oxygen generation. The in situ hyaluronic acid capping endows nanodots highly selective uptake breast cancer cells both vitro vivo. Simultaneous chemodynamic NIR-triggered photothermal/photodynamic activities result synergistic cell death 98% inhibition single-dose mouse model study. Therefore, show remarkable potential single nanoplatform-actuated drug-free multimodal therapy.

Язык: Английский

Процитировано

0