Engineering materials, Год журнала: 2025, Номер unknown, С. 231 - 257
Опубликована: Янв. 1, 2025
Язык: Английский
Supramolecular Materials, Год журнала: 2025, Номер unknown, С. 100100 - 100100
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Nanoscale Advances, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Chronic wound treatment poses a substantial challenge to healthcare systems. Certain herbal medicines have demonstrated clinical efficacy in promoting chronic healing, yet their therapeutic mechanisms at the molecular level remain elusive due complex composition and multifaceted nature. In this study, Ba-Hao ointment (BHO), sophisticated formulation with diverse ingredients, is selected as model precisely investigate its wound-healing mechanism. Network pharmacology analysis docking simulations reveal that BHO specifically interacts key proteins, including vascular endothelial growth factor A (VEGFA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), suggesting ability modulate critical biological pathways involved inflammation tissue regeneration. Experimental validation further demonstrates significantly promotes cell proliferation, suppresses bacterial infection, enhances expression of essential factors such epidermal (EGF) VEGFA normal human dermal fibroblasts (NHDF), all which are vital for effective healing. vivo studies confirm accelerates closure, reduces inflammation, development well-organized granulation via activation PI3K-Akt signaling pathway. This study interesting since it unveils BHO's role furthering medicine insights.
Язык: Английский
Процитировано
0
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 252, С. 114703 - 114703
Опубликована: Апрель 12, 2025
Язык: Английский
Процитировано
0
Engineering materials, Год журнала: 2025, Номер unknown, С. 231 - 257
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0