Cobalt catalyzed alkenylation/annulation reactions of alkynes via C–H activation: A review

Tetrahedron, Год журнала: 2023, Номер 132, С. 133248 - 133248

Опубликована: Янв. 9, 2023

Язык: Английский

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Carbon-carbon cross coupling reactions assisted by Schiff base complexes of Palladium, cobalt and copper: A brief overview

Inorganica Chimica Acta, Год журнала: 2023, Номер 551, С. 121478 - 121478

Опубликована: Март 15, 2023

Язык: Английский

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Stereoselective C–O silylation and stannylation of alkenyl acetates

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Март 15, 2023

Facile formation of carbon-heteroatom bonds is a long-standing objective in synthetic organic chemistry. However, direct cross-coupling with readily accessible alkenyl acetates via inert C‒O bond-cleavage for the bond construction remains challenging. Here we report practical preparation stereoselective tri- and tetrasubstituted silanes stannanes by performing cobalt-catalyzed silylation stannylation using silylzinc pivalate stannylzinc chloride as nucleophiles. This protocol features complete control chemoselectivity, stereoselectivity, well excellent functional group compatibility. The resulting show high reactivities arylation alkenylation Hiyama Stille reactions. utility further illustrated facile late-stage modifications natural products drug-like molecules. Mechanistic studies suggest that reaction might involve chelation-assisted oxidative insertion cobalt species to bond. We anticipate our findings should prove instrumental potential applications this technology syntheses drug discoveries medicinal

Язык: Английский

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Bulky NHC–Cobalt Complex-Catalyzed Highly Markovnikov-Selective Hydrosilylation of Alkynes

Catalysts, Год журнала: 2023, Номер 13(3), С. 510 - 510

Опубликована: Март 2, 2023

The hydrosilylation of alkynes is one the most attractive and, at same time, challenging catalytic transformations, usually demanding use noble transition metals. We describe a system, based on cobalt(0) complex and bulky N-heterocyclic carbene (NHC) ligands, permitting highly effective broad scope silanes. application NHC ligands allowed decrease in amount cobalt necessary for an reaction run to 2.5 mol% provided excellent selectivity towards α-vinylsilanes. developed method tolerates number substituted aryl, alkyl, silyl acetylenes. Moreover, it suitable both tertiary secondary Our findings confirm that steric hindrance around metal center can effectively increase activity catalyst ensure better than those analogous complexes bearing smaller ligands.

Язык: Английский

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The literature of heterocyclic chemistry, part XXII, 2022

Advances in heterocyclic chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Exploration of Regulation of Alcohol Dehydrogenation Reaction of Dibenzimidazole-Based Ruthenium Complexes

Molecules, Год журнала: 2025, Номер 30(4), С. 842 - 842

Опубликована: Фев. 12, 2025

This work demonstrates the synthesis of a series Ru(II) complexes with dibenzimidazole-based ligands and investigates spatial relationship between ligand structure complexes. It explores effect substituent changes on N-Ru-N bond angle complexes, as well distance from Ru center to aryl group, utilizes these catalyze benzyl alcohol dehydrogenation in toluene. was found that [Ru]-complex configuration electron donating groups had larger higher catalytic performance at ruthenium center, yield 91.2%. Moreover, its umbrella hydrocarbon sufficient allow for attack reactant molecules occurrence reactions. The reaction mechanism subsequently derived. manuscript is expected provide assistance inspiration development high-performance catalysts

Язык: Английский

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Cobalt N ‐Heterocyclic Carbene Complexes in Organic Synthesis

Patai's chemistry of functional groups, Год журнала: 2025, Номер unknown, С. 1 - 53

Опубликована: Фев. 26, 2025

Abstract Since the first report in 2003 of a [2 + 2 1] cycloaddition between enynes and carbon monoxide catalyzed by well‐defined cobalt complex containing an NHC ligand, homogeneous catalysis using complexes combination with NHCs as ancillary ligands has witnessed ever‐growing interest which been translated into various significant advances, mainly during past decade. In this chapter, different methodologies giving rise to Co(NHC) are surveyed. The major chemical transformations either or situ generated catalytic systems detailed, highlighting role ligand. addition cycloadditions, includes hydrogenation hydroelementation alkenes alkynes, cross‐couplings, CH activation/functionalization reactions, other reactions.

Язык: Английский

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Co(III)-Catalyzed Three-Component Assembling of 2-Pyridones with Dienes and Formaldehyde via C–H Bond Activation

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Here, we have demonstrated a Co(III)-catalyzed C–H functionalization of substituted pyridones with dienes and para-formaldehyde via three-component sequential reaction. A library homoallylic alcohols is synthesized high regio- chemoselectivity. The reaction scope widely compatible various N-pyridyl-2-pyridones, butadiene, dienes. Interestingly, N-pyridyl-4-pyridone also participated in the product was further converted into dihydrofuran-derived N-pyridyl-2-pyridone derivatives. convincing mechanism mechanistic investigations are described to justify current methodology.

Язык: Английский

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Cobalt(III) Complexes of Pyridine-Functionalized Chelating NHC Ligands: Effective Catalysts for the Olefination of Alcohols Using Sulfones

Organometallics, Год журнала: 2024, Номер 43(13), С. 1482 - 1489

Опубликована: Июнь 26, 2024

Several air-stable cobalt(III) complexes 1a-d featuring pyridine-functionalized NHC ligand systems were synthesized and completely characterized. These then explored as phosphine-free catalysts for the olefination of alcohols with sulfones, among studied here, benzimidazolylidene-supported 1b complex acetylacetonate (acac) a labile co-ligand was noted to be most active one, which also successful broad range sulfones providing diverse olefins. It is important mention that this first example such protocol catalyzed by cobalt. Furthermore, utility present demonstrated gram-scale reaction postsynthetic modifications obtained compounds. Finally, based on various control experiments including detection intermediates kinetic studies, plausible mechanism proposed.

Язык: Английский

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Selective zirconocene hydride-catalyzed semi-hydrogenation of terminal alkynes

Tetrahedron, Год журнала: 2023, Номер 133, С. 133267 - 133267

Опубликована: Янв. 18, 2023

Based on our recent findings in the area of zirconocene hydride catalysis, we have identified a mild and chemoselective strategy for formal semi-hydrogenation terminal alkynes utilizing catalytic quantities Schwartz's reagent or Cp2ZrCl2. This protocol accommodates variety functional groups, delivering monosubstituted alkenes bearing ester, nitrile, epoxy, amino, halo, sulfide hydroxyl groups.

Язык: Английский

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