The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(14), С. 10393 - 10402
Опубликована: Июль 2, 2024
α-Quaternary
amino
acids
have
found
application
in
many
biologically
relevant
compounds
and
pharmaceuticals.
Although
there
are
methods
for
the
synthesis
of
α-quaternary
acids,
most
them
mainly
realized
with
aid
transition
metals
complex
ligands.
We
present
herein
a
2,7-Br-4CzIPN
catalyzed
regioselective
alkylation
azlactones
redox-active
esters
via
radical-radical
couplings.
Strikingly,
this
approach
is
devoid
any
metal
or
additive
shows
broad
scope
superior
sensitive
functional
group
compatibility.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 9, 2024
Abstract
Development
of
mild,
robust
and
metal‐free
catalytic
approach
for
the
hydrosilylation
alkenes
is
critical
to
advancement
modern
organosilicon
chemistry
given
their
powerful
capacity
in
construction
various
C−Si
bonds.
Herein,
we
wish
disclose
a
visible
light‐triggered
organophotocatalytic
strategy,
which
proceeds
via
triplet
energy
transfer
(
EnT
)‐enabled
radical
chain
pathway.
Notably,
this
redox‐neutral
protocol
capable
accommodating
broad
spectrum
electron‐deficient
‐rich
with
excellent
functional
group
compatibility.
Electron‐deficient
are
more
reactive
reaction
could
be
finished
within
couple
minutes
even
PBS
solution
extremely
low
concentration,
suggests
its
click‐like
potential
organic
synthesis.
The
preparative
power
transformations
has
been
further
highlighted
number
complex
settings,
including
late‐stage
functionalization
scale‐up
experiments.
Furthermore,
although
only
highly
(TMS)
3
SiH
suitable
hydrosilane
substrate,
our
studies
revealed
great
reactivity
versatility
Si−
diverse
Si−Si
bond
cleavage‐based
transformations,
enabling
rapid
introduction
groups
facile
valuable
quaternary
silicon
architectures.
