Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(18), С. 3101 - 3106
Опубликована: Авг. 16, 2023
Abstract
We
developed
the
remote
selective
C−H
bromination
for
synthesis
of
C4′‐brominated
biarylphosphine
oxides
using
FeBr
3
as
a
brominating
reagent.
C3′‐Brominated
products
were
obtained
in
reactions
with
substrates
bearing
2,4,6‐triisopropyl
substituent
on
bottom
ring.
Moreover,
direct
access
to
C5‐chlorinated
peri
‐substituted(1‐naphthalenyl)phosphines
is
FeCl
chlorinating
These
halogenated
compounds
can
be
utilized
cross‐coupling
construct
functionalized
phosphine
oxides.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 6, 2023
Catalytic
cross-couplings
of
tertiary
alkyl
electrophiles
with
carbon
nucleophiles
offer
a
powerful
platform
for
constructing
quaternary
centers,
which
are
prevalent
in
bioactive
molecules.
However,
these
reactions
remain
underdeveloped
primarily
because
steric
challenges
that
impede
efficient
bond
formation.
Herein,
we
describe
the
copper-catalyzed
synthesis
such
centers
through
C(sp3)-C(sp2)
bond-forming
reaction
between
halides
and
arene
rings
aniline
derivatives,
enabled
by
strategic
implementation
bidentate
bis(cyclopropenimine)
ligands.
The
copper
catalyst
bound
two
imino-nitrogen
atoms
ligands,
have
never
been
employed
metal
catalysis
previously,
is
highly
effective
rapidly
activating
to
generate
radicals,
allowing
them
react
aryl
under
mild
conditions
remarkably
short
times
(1-2
h).
Various
bearing
carbonyl
functional
groups
can
be
coupled
secondary
or
primary
anilines,
furnishing
range
good
yields.
Several
mechanistic
observations
support
generation
copper(II)
species
radicals
as
result
elucidate
steps
proposed
catalytic
cycle.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
22(1), С. 80 - 84
Опубликована: Ноя. 22, 2023
Construction
of
the
sterically
demanding
Csp2(oS)-Csp3(T)
bond
was
achieved
by
carrying
out
Pd-catalyzed
carboxylate-directed
Mizoroki-Heck
reaction
under
extra-ligand-free
aqueous
conditions.
The
cooperative
role
presence
water
with
absence
phosphine
ligand
proposed
to
accelerate
migratory
insertion
process
considerably,
delivering
a
broad
substrate
scope.
Chemistry - An Asian Journal,
Год журнала:
2023,
Номер
19(4)
Опубликована: Дек. 20, 2023
Herein,
we
have
reported
the
synthesis
of
a
macrocyclic
organosulfur
ligand
(L1)
having
seventeen-membered
ring.
Subsequently,
corresponding
trans-palladium
complex
(C1)
bulky
was
synthesized
by
reacting
it
with
PdCl
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
365(18), С. 3101 - 3106
Опубликована: Авг. 16, 2023
Abstract
We
developed
the
remote
selective
C−H
bromination
for
synthesis
of
C4′‐brominated
biarylphosphine
oxides
using
FeBr
3
as
a
brominating
reagent.
C3′‐Brominated
products
were
obtained
in
reactions
with
substrates
bearing
2,4,6‐triisopropyl
substituent
on
bottom
ring.
Moreover,
direct
access
to
C5‐chlorinated
peri
‐substituted(1‐naphthalenyl)phosphines
is
FeCl
chlorinating
These
halogenated
compounds
can
be
utilized
cross‐coupling
construct
functionalized
phosphine
oxides.
