Recent Advances in Radical Coupling Reactions Directly Involving Bicyclo[1.1.1]pentane (BCP)

Topics in Current Chemistry, Год журнала: 2025, Номер 383(1)

Опубликована: Янв. 18, 2025

Язык: Английский

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N-Phenylphenothiazine-based Hyper-cross-linked Polymers for Recyclable, Heterogeneous Photocatalysis of Organic Transformations: A Strategy to Access 6-Difluoromethyl-phenanthridines

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Herein, a N-phenylphenothiazine-based hyper-cross-linked polymer (PTH-HCP) was finely designed and constructed, which serves as metal-free heterogeneous photocatalyst for organic transformations. Characterization experiments have shown that this demonstrates outstanding stability, extensive surface area, exceptional photoelectric response properties. Moreover, PTH-HCP showed good catalytic efficiency recyclability in the photochemically driven difluoromethylation/cyclization reactions. This work provides strategy design construction of photocatalysts offers support their broad prospects synthetic applications.

Язык: Английский

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Synthesis of Nafimidone Derivatives by Visible-Light-Induced α-C—H Functionalization of Carbonyl

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(2), С. 677 - 677

Опубликована: Янв. 1, 2025

Язык: Английский

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Chiral Lewis Acid-Catalyzed Intramolecular [2 + 2] Photocycloaddition: Enantioselective Synthesis of Azaarene-Functionalized Azabicyclo[2.1.1]hexanes and Bicyclo[1.1.1]pentanes

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

We present an asymmetric intramolecular [2 + 2] photocycloaddition reaction enabled by a dual catalyst system involving DPZ as photosensitizer and chiral Sc(III) complex, leading to azaarene-functionalized 2-azabicyclo[2.2.1]hexanes (aza-BCHs). The approach efficiently preventing racemization during subsequent nitrogen-deletion skeletal editing of aza-BCHs yield 2-substituted bicyclo[1.1.1]pentanes (BCPs). method achieves high ee broad substrate scope, including the successful formation all-carbon quaternary stereocenters. Furthermore, activation simple azaarene substrates Lewis acids in photocatalysis highlights notable contribution this field.

Язык: Английский

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Photoredox-Catalyzed Decarboxylative Elimination via Halogen Atom Transfer

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Enamides and enecarbamates offer an excellent balance between stability reactivity. Decarboxylation of widely available amino acids offers a green efficient alternative to accessing these reagents. The present study describes photocatalytic approach for the direct decarboxylative synthesis enamides via sequential radical decarboxylation putative halogen-atom transfer (XAT). This operationally simple, economical protocol is scalable allows mild reaction conditions short times. In addition, it obviates need transition metals preactivation carboxylic acids.

Язык: Английский

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