Biocatalytic desymmetrization for synthesis of chiral enones using flavoenzymes
Nature Synthesis,
Год журнала:
2024,
Номер
3(11), С. 1340 - 1348
Опубликована: Июль 1, 2024
Язык: Английский
Structure, Oligomerization, and Thermal Stability of a Recently Discovered Old Yellow Enzyme
Proteins Structure Function and Bioinformatics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
ABSTRACT
The
Old
Yellow
Enzyme
from
Ferrovum
sp.
JA12
(FOYE)
displays
an
unusual
thermal
stability
for
enzyme
isolated
a
mesophilic
organism.
We
determined
the
crystal
structure
of
this
and
performed
bioinformatic
characterization
to
get
insights
into
its
stability.
tetrameric
quaternary
structure;
however,
unlike
other
homologs,
it
clusters
in
separate
phylogenetic
group
possesses
unique
interactions
that
stabilize
oligomeric
state.
is
mainly
due
unusually
high
number
intramolecular
hydrogen
bonds.
Finally,
study
provides
general
analysis
forces
driving
oligomerization
Enzymes.
Язык: Английский
New Synthetic Approaches for the Construction of Enantioenriched Molecules Bearing Quaternary Stereocenters
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(21), С. 4294 - 4322
Опубликована: Авг. 17, 2024
Abstract
Optically
active
molecule
architectures
stand
as
an
important
class
of
organic
compounds
and
occupy
a
key
role
in
academic
industrial
communities.
Particularly,
the
molecules
bearing
quaternary
carbon
are
vital
importance
because
its
favorable
conformation
valuable
three‐dimensional
molecules,
which
frequently
play
broad
spectrum
functional
materials,
pharmaceutical
relevant
natural
agrochemicals.
Over
past
few
decades,
large
number
synthetic
strategies
for
enantioselective
construction
with
chiral
centers
have
been
focus
research
initiatives.
In
this
review,
state‐of‐the‐art
toward
synthesis
enantioenriched
stereocenters
summarized,
could
be
segmented
into
four
categories:
1)
Construction
optically
by
addition
to
prochiral
sp
2
carbon;
2)
all‐carbon
via
substitution
at
non‐chiral
tetra‐substituted
3)
kinetic
resolution;
4)
desymmetrization
reactions.
Язык: Английский
HTE-Enabled Development of an Ene-Reductase-Catalyzed Desymmetrization: Remote Control of All-Carbon Quaternary γ-Centers
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
We
report
the
remote
stereocontrol
of
all-carbon
quaternary
γ-centers
via
an
ene-reductase
(ERED)-catalyzed
desymmetrization
prochiral
cyclohexadienones.
By
leveraging
high-throughput
experimentation
(HTE)
protocols,
we
were
able
to
rapidly
identify
EREDs
capable
desymmetrizing
both
spirocyclic
cyclohexadienones
and
non-spirocyclic
2,6-disubstituted
cyclohexadienone
substrates
in
up
85%
yield
with
excellent
levels
stereoselectivity
(up
>99%
ee
>20:1
dr)
under
mild
reaction
conditions.
Язык: Английский