Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 4, 2024
Comprehensive
Summary
Herein,
an
unprecedented
nickel‐catalyzed
regioselective
hydroalkynylation
of
unsymmetrical
internal
alkynes
was
realized
with
steric
hindered
resistance
selectivity
via
the
cyano‐directing
group
strategy.
Significantly,
resulting
1,3‐enyne
products
could
be
effectively
employed
in
synthesis
novel
nitrogen‐containing
tricyclics
compounds,
that
provided
potential
candidate
compound
8a
(IC
50
=
2.6—6.1
μmol/L)
for
anti‐tumor
cell
proliferation
activity.
Therefore,
this
work
not
only
improves
transition‐metal‐
catalyzed
strategy
alkynes,
but
also
exhibits
versatility
1,3‐enynes
construction
complex
bioactive
chemical
space.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(67)
Опубликована: Авг. 13, 2024
Abstract
Difunctionalizations
of
alkenes
represent
one
the
most
straightforward
protocols
to
build
molecular
complexity
due
simultaneous
construction
two
vicinal
bonds
cross
π‐bond
alkenes.
It
is
extremely
attractive
yet
challenging
control
stereochemistry
outcome
this
event.
Over
past
years,
visible‐light
and
Ni‐catalyzed
asymmetric
difunctionalizations
provide
an
environmental
benign
promising
solution
for
saturated
carbon
centers
with
regio‐
enantioselectivity.
In
Concept,
initiative
progress
enantioselective
enabled
by
nickel
catalysis
has
been
summarized.
Moreover,
further
efforts
directions
development
mediated
discussed.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 4, 2024
Comprehensive
Summary
Herein,
an
unprecedented
nickel‐catalyzed
regioselective
hydroalkynylation
of
unsymmetrical
internal
alkynes
was
realized
with
steric
hindered
resistance
selectivity
via
the
cyano‐directing
group
strategy.
Significantly,
resulting
1,3‐enyne
products
could
be
effectively
employed
in
synthesis
novel
nitrogen‐containing
tricyclics
compounds,
that
provided
potential
candidate
compound
8a
(IC
50
=
2.6—6.1
μmol/L)
for
anti‐tumor
cell
proliferation
activity.
Therefore,
this
work
not
only
improves
transition‐metal‐
catalyzed
strategy
alkynes,
but
also
exhibits
versatility
1,3‐enynes
construction
complex
bioactive
chemical
space.
