A Photo- and Cobalt-Catalyzed Highly Selective and Divergent Hydrofunctionalization of 1,3-Dienes with Phenols
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
An
applicable
cobalt-hydride-mediated
selective,
divergent
hydroetherification
and
sequential
hydroetherification/hydroarylation
of
1,3-dienes
with
simple
phenol
feedstocks
under
a
photoredox
cobalt
catalytic
system
have
been
developed.
A
variety
allyl
aryl
ethers
value-added
chroman
derivatives
can
be
obtained
in
good
to
excellent
yields
stereoselectivity.
This
method
not
only
obviates
the
need
for
extra
hydrosilanes
stoichiometric
oxidants,
thereby
offering
exceedingly
mild
conditions
alkene
hydroetherification,
but
also
represents
first
case
CoH-HAT-catalyzed
double
hydrofunctionalization
alkenes
sole
nucleophile.
The
continuous
selective
bond-forming
expands
applications
cobalt-hydride
MHAT
reaction
provides
novel
approach
design
synthesis
heterocyclic
molecules.
Язык: Английский
Cobalt-catalyzed radical hydroamination of olefins
Qingyu Xing,
Preeti P. Chandrachud,
Khalilia Tillett
и другие.
Trends in Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
New chemistry of alkynyl trifluoroborates under transition metal catalyst-free conditions
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(20), С. 5985 - 6003
Опубликована: Янв. 1, 2024
This
review
summarizes
recent
advances
in
alkynyl
trifluoroborate
chemistry,
emphasizing
their
unique
reactivity
and
stability
organic
synthesis
biological
applications
under
transition
metal
catalyst-free
conditions.
Язык: Английский
Electrooxidative Pd-Catalyzed Remote Hydrofunctionalization of Alkenes with Nucleophiles
ACS Catalysis,
Год журнала:
2024,
Номер
14(21), С. 15858 - 15868
Опубликована: Окт. 11, 2024
The
catalytic
hydrofunctionalization
of
alkenes
with
nucleophiles
via
the
generation
carbocationic
intermediates
has
been
extensively
studied
as
an
efficient
strategy
for
regioselective
installation
functional
groups
on
alkene
feedstocks.
However,
since
established
methods
are
confined
to
functionalization
position
where
is
originally
located,
it
highly
desirable
develop
a
broadly
applicable
platform
that
offers
alternative
regioselectivity
otherwise
challenging
achieve
existing
protocols.
Herein,
we
report
remote
method
enabled
by
electrooxidative
palladium
hydride
catalysis.
key
success
formation
carbocation
intermediate
through
mechanistic
pathway,
which
involves
chain-walking
process
followed
anodic
oxidation
organopalladium
species.
This
allows
terminal
and
internal
broad
range
oxygen,
carbon,
nitrogen,
fluoride
nucleophiles,
including
complex
drug-like
molecules.
Язык: Английский