Visible‐Light‐Induced C−H Amidation of (Hetero)arenes with Hypervalent Iodine(III) Reagents
Asian Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Abstract
A
visible‐light‐promoted
C−H
amidation
of
(hetero)arenes
with
hypervalent
iodine
reagents
has
been
successfully
achieved
good
yields.
The
high
efficiency,
broad
substrate
range
and
functional
group
compatibility
demonstrated
the
utility
method.
Moreover,
this
protocol
was
suitable
for
late‐stage
functionalization
natural
products.
Mechanistic
studies
have
shown
that
N‐centred
saccharin
radical
mediates
arenes.
Язык: Английский
Advances in C‐N bond Formation via N‐centered Radicals from N‐Aminopyridinium Reagents
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
Abstract
Nitrogen‐centered
radicals
(NCRs)
have
gained
significant
attention
due
to
their
high
reactivity,
which
facilitates
many
useful
and
challenging
transformations,
particularly
in
the
formation
of
C−N
bonds.
In
this
regard,
N
‐aminopridinium
reagents
are
easily
accessible
substrates
that
readily
generate
‐centered
radicals,
can
be
trapped
by
arenes,
olefins,
alkynes
even
alkanes
under
visible
light
irradiation.
recent
years,
amination
strategies
involving
‐aminopyridinium
salts
grown
remarkably
attracted
considerable
interest
within
synthetic
community.
This
review
comprehensively
includes
all
advances
bond
construction
via
derived
from
substrates.
Язык: Английский
The Synthesis of Sulfonyl Fluoride Functionalized 2-Aminothiazoles Using a Diversity Oriented Clicking Strategy
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
We
present
a
Diversity
Oriented
Clicking
approach
to
synthesize
library
of
novel
clickable
N-substituted
2-aminothiazoles
which
serve
as
versatile
hubs
for
SuFEx
click
chemistry
diversification.
Leveraging
the
spring-loaded
reactivity
2-Substituted-Alkynyl-1-Sulfonyl
Fluoride
(SASF)
connectors,
transformation
is
simple
perform,
tolerant
wide
range
functionality,
and
regioselective
single
product.
Finally,
we
propose
detailed
stepwise
reaction
mechanism
that
supported
by
experimental
computational
analysis.
Язык: Английский