The Synthesis of Sulfonyl Fluoride Functionalized 2-Aminothiazoles Using a Diversity Oriented Clicking Strategy DOI

Joshua W. Kop,

Carol Hua, Daniel L. Priebbenow

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

We present a Diversity Oriented Clicking approach to synthesize library of novel clickable N-substituted 2-aminothiazoles which serve as versatile hubs for SuFEx click chemistry diversification. Leveraging the spring-loaded reactivity 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) connectors, transformation is simple perform, tolerant wide range functionality, and regioselective single product. Finally, we propose detailed stepwise reaction mechanism that supported by experimental computational analysis.

Язык: Английский

Visible‐Light‐Induced C−H Amidation of (Hetero)arenes with Hypervalent Iodine(III) Reagents DOI Open Access
Xiaojuan Wang, He Wang, Zhenkun Ma

и другие.

Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Abstract A visible‐light‐promoted C−H amidation of (hetero)arenes with hypervalent iodine reagents has been successfully achieved good yields. The high efficiency, broad substrate range and functional group compatibility demonstrated the utility method. Moreover, this protocol was suitable for late‐stage functionalization natural products. Mechanistic studies have shown that N‐centred saccharin radical mediates arenes.

Язык: Английский

Процитировано

0

Advances in C‐N bond Formation via N‐centered Radicals from N‐Aminopyridinium Reagents DOI

Farrukh Sajjad,

Chang Lu, Tie‐Gen Chen

и другие.

European Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

Abstract Nitrogen‐centered radicals (NCRs) have gained significant attention due to their high reactivity, which facilitates many useful and challenging transformations, particularly in the formation of C−N bonds. In this regard, N ‐aminopridinium reagents are easily accessible substrates that readily generate ‐centered radicals, can be trapped by arenes, olefins, alkynes even alkanes under visible light irradiation. recent years, amination strategies involving ‐aminopyridinium salts grown remarkably attracted considerable interest within synthetic community. This review comprehensively includes all advances bond construction via derived from substrates.

Язык: Английский

Процитировано

0

The Synthesis of Sulfonyl Fluoride Functionalized 2-Aminothiazoles Using a Diversity Oriented Clicking Strategy DOI

Joshua W. Kop,

Carol Hua, Daniel L. Priebbenow

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

We present a Diversity Oriented Clicking approach to synthesize library of novel clickable N-substituted 2-aminothiazoles which serve as versatile hubs for SuFEx click chemistry diversification. Leveraging the spring-loaded reactivity 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) connectors, transformation is simple perform, tolerant wide range functionality, and regioselective single product. Finally, we propose detailed stepwise reaction mechanism that supported by experimental computational analysis.

Язык: Английский

Процитировано

0