Nine-Membered Ketolactams by Oxidative Cyclization Expansion DOI
Yun Yang, Ben Ebel, Iris M. Oppel

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Considerable progress has been made over decades in synthetic organic chemistry order to build up molecular complexity, often through the design of advanced catalytic systems. Yet, simply exposing molecules benchmark oxidants catalyst free conditions can sometimes lead surprising and highly valuable products. Thus, a method for accessing rare 9-membered ketolactams is herein described, under mild oxidative conditions. Key 18O 17O label experiments revealed an unexpected oxygen atom migration event ring expansion process. The scope, mechanism, applications, 9 7 membered contraction opportunities are discussed.

Язык: Английский

Nine-Membered Ketolactams by Oxidative Cyclization Expansion DOI
Yun Yang, Ben Ebel, Iris M. Oppel

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Considerable progress has been made over decades in synthetic organic chemistry order to build up molecular complexity, often through the design of advanced catalytic systems. Yet, simply exposing molecules benchmark oxidants catalyst free conditions can sometimes lead surprising and highly valuable products. Thus, a method for accessing rare 9-membered ketolactams is herein described, under mild oxidative conditions. Key 18O 17O label experiments revealed an unexpected oxygen atom migration event ring expansion process. The scope, mechanism, applications, 9 7 membered contraction opportunities are discussed.

Язык: Английский

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