Copper-catalyzed domino cyclization of anilines and cyclobutanone oxime: a scalable and versatile route to spirotetrahydroquinoline derivatives DOI Creative Commons

Qingqing Jiang,

Xin Lei, Pan Gao

и другие.

Beilstein Journal of Organic Chemistry, Год журнала: 2025, Номер 21, С. 749 - 754

Опубликована: Апрель 9, 2025

In this study, we report the copper-catalyzed synthesis of tetrahydroquinoline derivatives via a domino reaction aniline with cyclobutanone oxime. This method demonstrates selective approach for generating bioactive scaffolds, which have broad applications in pharmaceutical chemistry. The conditions were optimized effective formation varying substituents, showing high yields under mild conditions. Mechanistic studies suggest catalytic cycle involving nucleophilic attack by on oxime, followed cyclization to form desired product.

Язык: Английский

Copper-catalyzed domino cyclization of anilines and cyclobutanone oxime: a scalable and versatile route to spirotetrahydroquinoline derivatives DOI Creative Commons

Qingqing Jiang,

Xin Lei, Pan Gao

и другие.

Beilstein Journal of Organic Chemistry, Год журнала: 2025, Номер 21, С. 749 - 754

Опубликована: Апрель 9, 2025

In this study, we report the copper-catalyzed synthesis of tetrahydroquinoline derivatives via a domino reaction aniline with cyclobutanone oxime. This method demonstrates selective approach for generating bioactive scaffolds, which have broad applications in pharmaceutical chemistry. The conditions were optimized effective formation varying substituents, showing high yields under mild conditions. Mechanistic studies suggest catalytic cycle involving nucleophilic attack by on oxime, followed cyclization to form desired product.

Язык: Английский

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