Iron-Catalyzed Three-Component Reactions of Cyclopropanols with Alkenes and N-Heteroarenes via Ring-Opening and C–H Functionalization

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

An iron-catalyzed ring-opening multicomponent reaction of cyclopropyl alcohols with alkenes and N-heteroarenes involving aryl C(sp2)-H functionalization was developed. This protocol facilitates the regioselective introduction both β-carbonyl moiety an N-heteroarene group across C═C bond alkene, thus allowing a straightforward, efficient, facile access to 5-heteroarene ketones. In this process, strategy relies on alkyl radical formation from alcohols, addition bonds, heteroaryl cascades. general approach displays excellent selectivity control broad functional-group tolerance.

Язык: Английский

Catalytic dynamic kinetic reductive addition of simple aldehydes and aldimines with heterobiaryl triflates: harnessing both central and axial chirality

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A nickel-catalyzed intramolecular dynamic kinetic resolution (DKR) strategy has been developed for the enantioselective synthesis of axially chiral heterobiaryls from racemic azabiaryl triflates. Using a reductive addition mechanism, this method controls both axial and central chirality, offering broad substrate scope, excellent enantioselectivity, atroposelectivity. The resulting were effectively employed as organocatalysts ligands in asymmetric transformations, highlighting their synthetic utility. Mechanistic studies indicate synergy between nickel-mediated stereochemical inversion, addressing challenges concurrent control.

Язык: Английский

Crystal structure of 7,9-dimethoxy-2-methyl-4-propylbenzo[f]isoquinolin-5-yl 4-bromobenzoate, C₂₆H₂₄BrNO₄

Zeitschrift für Kristallographie - New Crystal Structures, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

Abstract C 26 H 24 BrNO 4 , monoclinic, P 2 1 / c (no. 14), a = 11.0275(5) Å, b 21.172(10) 10.145(4) β 103.929(8)°, V 2298.9(17) Å 3 Z 4, R gt ( F ) 0.0653, wR ref 0.2027, T 296 K.

Язык: Английский