Iridium-Catalyzed Asymmetric Allylic Substitution Reactions

Chemical Reviews, Год журнала: 2018, Номер 119(3), С. 1855 - 1969

Опубликована: Дек. 24, 2018

In this review, we summarize the origin and advancements of iridium-catalyzed asymmetric allylic substitution reactions during past two decades. Since first report in 1997, Ir-catalyzed have attracted intense attention due to their exceptionally high regio- enantioselectivities. been significantly developed recent years many respects, including ligand development, mechanistic understanding, substrate scope, application synthesis complex functional molecules. an explicit outline ligands, mechanism, scope nucleophiles, applications is presented.

Язык: Английский

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Stereodivergent Synthesis of α,α-Disubstituted α-Amino Acids via Synergistic Cu/Ir Catalysis

Journal of the American Chemical Society, Год журнала: 2018, Номер 140(4), С. 1508 - 1513

Опубликована: Янв. 5, 2018

Cu/Ir dual catalysis has been developed for the stereodivergent α-allylation of aldimine esters. The method enables preparation a series nonproteinogenic α-amino acids (α-AAs) bearing two contiguous stereogenic centers in high yield with excellent stereoselectivity. All four product stereoisomers could be obtained from same set starting materials via pairwise combination chiral catalysts. Notably, one-pot protocol successfully applied bimetallic complexes to simplify manipulation catalysis. This further utilized construction key intermediate bioactive pyrrolidine derivative and concise synthesis plant growth regulator (2S,3S)-2-amino-3-cyclopropylbutanoic acid.

Язык: Английский

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Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters

Journal of the American Chemical Society, Год журнала: 2018, Номер 140(6), С. 2080 - 2084

Опубликована: Янв. 30, 2018

We describe a fully stereodivergent synthesis of range α,α-disubstituted α-amino acids via an Ir/Cu-catalyzed α-allylation readily available imine esters. The introduction Cu-Phox complex-activated ester into the chiral iridium-catalyzed allylic allylation process is crucial for its high reactivity and excellent enantio- diastereoselectivity (up to >99% ee >20:1 dr). Importantly, two catalysts allow full control over configuration stereocenters, affording all stereoisomers desired products. utility this methodology was demonstrated by synthesizing dipeptides analogues bioactive molecules in manner.

Язык: Английский

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Enantioselective Formation of Quaternary Centers by Allylic Alkylation with First-Row Transition-Metal Catalysts

Chemical Reviews, Год журнала: 2021, Номер 121(7), С. 4084 - 4099

Опубликована: Фев. 11, 2021

Asymmetric allylic alkylation mediated by transition metals provides an efficient strategy to form quaternary stereogenic centers. While this transformation is dominated the use of second- and third-row (e.g., Pd, Rh, Ir), recent developments have revealed potential first-row metals, which provide not only a less expensive potentially equally alternative but also new mechanistic possibilities. This review summarizes examples for assembly stereocenters using prochiral substrates hard, achiral nucleophiles in presence copper complexes highlights complementary approaches with soft, catalyzed chiral cobalt nickel complexes.

Язык: Английский

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Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(18), С. 8097 - 8103

Опубликована: Апрель 19, 2020

A stereodivergent Pd/Cu catalyst system has been developed for the unprecedented dynamic kinetic asymmetric transformation (DyKAT) of racemic unsymmetrical 1,3-disubstituted allylic acetates with prochiral aldimine esters. series α,α-disubstituted α-amino acids bearing vicinal stereocenters were easily prepared excellent enantioselectivities (up to >99% ee) and diastereoselectivities >20:1 dr). Moreover, all four stereoisomers product can be readily obtained simply by switching configurations two chiral metal catalysts. Furthermore, present work highlights power synergistic catalysis consisting common bidentate ligands synthesis.

Язык: Английский

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Bimetallic Catalysis in Stereodivergent Synthesis

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(45)

Опубликована: Авг. 2, 2022

Abstract Bimetallic catalysis has emerged as an efficient strategy for the development of new chemical reactions. Importantly, this also provides a simple and powerful platform stereodivergent synthesis, whereby all possible stereoisomers products bearing two stereocenters can be easily prepared from same set starting materials. In Minireview, allylic substitution, propargylic hydrofunctionalization, annulation based on bimetallic been summarized. It is expected that more catalytic systems will developed applied synthesis valuable molecules.

Язык: Английский

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Enantio‐ and Diastereodivergent Synthesis of Spirocycles through Dual‐Metal‐Catalyzed [3+2] Annulation of 2‐Vinyloxiranes with Nucleophilic Dipoles

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(47), С. 24941 - 24949

Опубликована: Сен. 17, 2021

The development of efficient and straightforward methods for obtaining all optically active isomers structurally rigid spirocycles from readily available starting materials is great value in drug discovery chiral ligand development. However, the stereodivergent synthesis bearing multiple stereocenters remains an unsolved challenge owing to steric hindrance ring strain. Herein, we report enantio- diastereodivergent through dual-metal-catalyzed [3+2] annulation oxy π-allyl metallic dipoles with less commonly employed nucleophilic (imino esters). A series spiro compounds a pyrroline olefin were easily synthesized manner (up 19:1 dr, >99 % ee), which showed promise as new type N-olefin ligand. Preliminary mechanistic studies also carried out understand process this bimetallic catalysis.

Язык: Английский

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Transition-metal-catalyzed C–H allylation reactions

Chem, Год журнала: 2020, Номер 7(3), С. 555 - 605

Опубликована: Ноя. 13, 2020

Язык: Английский

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Iridium‐Catalyzed Asymmetric Allylic Dearomatization by a Desymmetrization Strategy

Angewandte Chemie International Edition, Год журнала: 2017, Номер 56(47), С. 15093 - 15097

Опубликована: Окт. 5, 2017

Abstract A desymmetrization strategy was developed involving iridium‐catalyzed allylic dearomatization of indoles. The six‐membered‐ring spiroindolenines contain three contiguous stereogenic centers, including an all‐carbon quaternary center, and were obtained in up to 99 % yield with ee >95:5 d.r. When treated a catalytic amount tosylic acid, six‐membered spiroindolenine undergoes unprecedented six‐to‐seven‐membered ring expansion, affording the corresponding hexahydroazepino[4,5‐ b ]indole.

Язык: Английский

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Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination

Journal of the American Chemical Society, Год журнала: 2019, Номер 141(29), С. 11430 - 11434

Опубликована: Июль 5, 2019

The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched carbonates bearing alkyl groups with both aromatic aliphatic amines has been developed. process allows rapid access in high yields exclusively selectivity excellent enantioselectivities (normally 99% ee) under mild reaction conditions.

Язык: Английский

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