Recent trends in biocatalysis

Chemical Society Reviews, Год журнала: 2021, Номер 50(14), С. 8003 - 8049

Опубликована: Янв. 1, 2021

Technological developments enable the discovery of novel enzymes, advancement enzyme cascade designs and pathway engineering, moving biocatalysis into an era technology integration, intelligent manufacturing enzymatic total synthesis.

Язык: Английский

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Enantioselective Radical Reactions Using Chiral Catalysts

Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 5842 - 5976

Опубликована: Янв. 24, 2022

Benefiting from the impressive increase in fundamental knowledge, last 20 years have shown a continuous burst of new ideas and consequently plethora catalytic methods for enantioselective radical reactions. This review aims to provide complete survey progress achieved over this latter period. The first part focuses on use chiral organocatalysts, these include catalysts covalently linked substrate those that interact with by weaker interactions like hydrogen bonds. second is devoted transition-metal redox catalysis which organized according increasing atomic number first-row transition metals (Ti, Cr, Fe, Mn, Co, Ni, Cu). Bioinspired manganese- iron-mediated hydroxylations oxidations are also discussed. A specific section dedicated reactivity Ru, Rh, Ir complexes as Lewis acids special focus at metal. Absorption photons result different events such energy transfer, single-electron hydrogen-atom transfer facilitating formation radicals. Organocatalysis has been successfully combined photocatalysts, opened pathways enlarging precursors available. merger photocatalysis organo- or metalla-photocatalysis brought novelty allowed discovery large original transformations. enzyme-catalyzed reactions involving intermediates largely benefit visible-light irradiation included review. provides comprehensive inventory goal detailing reaction mechanisms involved transformations any nonspecialist could find their own creativity invent yet unknown applications.

Язык: Английский

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Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses

Nature Chemistry, Год журнала: 2022, Номер 14(5), С. 489 - 499

Опубликована: Май 1, 2022

Язык: Английский

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Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 1052 - 1126

Опубликована: Ноя. 30, 2021

Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool the synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic processes launched in half last century exploited whole-cell microorganisms where specific enzyme at work was not known. In meantime, novel molecular biology methods, such efficient gene sequencing and triggered breakthroughs directed evolution rapid development process-stable with broad substrate scope good selectivities tailored substrates. To date, are employed to enable shorter, more efficient, sustainable alternative routes toward (established) small molecule APIs, additionally used perform standard reactions API efficiently. Herein, large-scale synthetic containing key steps >130 APIs approved drugs drug candidates compared corresponding chemical protocols (if available) regarding steps, reaction conditions, scale. review is structured according functional group formed reaction.

Язык: Английский

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Biocatalysis making waves in organic chemistry

Chemical Society Reviews, Год журнала: 2021, Номер 51(2), С. 594 - 627

Опубликована: Дек. 20, 2021

The many waves of biocatalysis have arisen to solve long-standing synthetic challenges. From industrially applied hydrolases enzymes catalysing selective C–C-bond formation, enables new tools access a plethora compounds.

Язык: Английский

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Enzymatic Conversion of CO₂: From Natural to Artificial Utilization

Chemical Reviews, Год журнала: 2023, Номер 123(9), С. 5702 - 5754

Опубликована: Янв. 24, 2023

Enzymatic carbon dioxide fixation is one of the most important metabolic reactions as it allows capture inorganic from atmosphere and its conversion into organic biomass. However, due to often unfavorable thermodynamics difficulties associated with utilization CO

Язык: Английский

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Combining chemistry and protein engineering for new-to-nature biocatalysis

Nature Synthesis, Год журнала: 2022, Номер 1(1), С. 18 - 23

Опубликована: Янв. 12, 2022

Язык: Английский

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Biocatalysis as Key to Sustainable Industrial Chemistry

ChemSusChem, Год журнала: 2022, Номер 15(9)

Опубликована: Март 3, 2022

The role and power of biocatalysis in sustainable chemistry has been continuously brought forward step by to its present outstanding position. problem-solving capabilities have realized numerous substantial achievements biology, engineering. Advances breakthroughs the life sciences interdisciplinary cooperation with clearly accelerated implementation biocatalytic synthesis modern chemistry. Resource-efficient manufacturing processes already provided benefits as well customer-centric value creation pharmaceutical, food, flavor, fragrance, vitamin, agrochemical, polymer, specialty, fine chemical industries. Biocatalysis can make significant contributions not only processes, but also design completely new value-creation chains. now be considered a key enabling technology implement

Язык: Английский

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Biocatalysed synthesis planning using data-driven learning

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Фев. 18, 2022

Abstract Enzyme catalysts are an integral part of green chemistry strategies towards a more sustainable and resource-efficient chemical synthesis. However, the use biocatalysed reactions in retrosynthetic planning clashes with difficulties predicting enzymatic activity on unreported substrates enzyme-specific stereo- regioselectivity. As now, only rule-based systems support using biocatalysis, while initial data-driven approaches limited to forward predictions. Here, we extend reaction as well pathway prediction models based Molecular Transformer architecture biocatalysis. The knowledge is learned from extensive data set publicly available biochemical aid new class token scheme enzyme commission classification number, which captures catalysis patterns among different enzymes belonging same hierarchy. model (top-1 accuracy 49.6%), single-step round-trip 39.6%) curated made facilitate adoption design greener processes.

Язык: Английский

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Expanding the Synthetic Toolbox through Metal–Enzyme Cascade Reactions

Chemical Reviews, Год журнала: 2023, Номер 123(9), С. 5297 - 5346

Опубликована: Янв. 10, 2023

The combination of metal-, photo-, enzyme-, and/or organocatalysis provides multiple synthetic solutions, especially when the creation chiral centers is involved. Historically, enzymes and transition metal species have been exploited simultaneously through dynamic kinetic resolutions racemates. However, more recently, linear cascades appeared as elegant solutions for preparation valuable organic molecules combining bioprocesses metal-catalyzed transformations. Many advantages are derived from this symbiosis, although there still bottlenecks to be addressed including successful coexistence both catalyst types, need compatible reaction media mild conditions, or minimization cross-reactivities. Therefore, here also provided by means coimmobilization, compartmentalization strategies, flow chemistry, etc. A comprehensive review presented focusing on period 2015 early 2022, which has divided into two main sections that comprise first use metals independent catalysts but working in an orchestral sequential manner, later their application bionanohybrid materials coimmobilization adequate supports. Each part classified different subheadings, based catalyzed catalyst, while development nonasymmetric stereoselective processes was considered section.

Язык: Английский

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