Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
39(1)
Опубликована: Сен. 17, 2024
ABSTRACT
Copper
complexes
exhibit
promising
anticancer
properties,
which
can
be
further
promoted
by
suitable
ligands.
In
this
study,
we
synthesized
and
investigated
the
effects
of
three
copper(I)
with
N‐heterocyclic
carbene
(NHC)
ligands
derived
from
phenanthroline‐functionalized
imidazole
salts.
The
synthesis
these
NHC‐copper(I)
(
Cu1
‐
Cu3
)
was
meticulously
characterized
using
NMR
elemental
analysis;
their
crystal
structures
were
delineated
X‐ray
diffraction.
Our
findings
illustrate
unique
geometric
configurations
complexes:
features
a
dinuclear
arrangement
off‐linear
geometry;
Cu2
are
bi‐copper
core
stabilized
two
phenanthroline‐modified
Crucially,
in
vitro
cytotoxic
evaluations
revealed
that
possess
suitability
activity.
Among
them,
exhibited
enhanced
cytotoxicity
activity,
achieving
half‐maximal
inhibitory
concentration
(IC
50
4.36
±
0.25
μM
colon
cancer
cell
line
HCT‐116,
markedly
surpassing
efficacy
cisplatin.
Subsequent
investigations
elucidated
notably
increases
intracellular
reactive
oxygen
species
(ROS)
levels
induces
mitochondrial
membrane
depolarization
endoplasmic
reticulum
stress,
leading
to
oxidative
stress‐mediated
apoptosis
cells.
The
title
compound,
[RuCl(C
6
H
)(C
14
10
N
2
)]BF
4
or
[Ru(η
-benzene)(
L
)Cl]
+
BF
−
[where
denotes
the
2-(pyridin-2-yl)quinoline
ligand],
crystallizes
in
monoclinic
space
group
P
1
/
c
.
coordination
environment
around
Ru
II
is
best
described
as
pseudo-octahedral,
resembling
familiar
half-sandwich
‘three-legged
piano-stool’
shape.
In
sphere,
η
-binding
benzene
ligand
coordinates
with
central
atom
occupying
‘seat’
of
stool
a
metal-to-centroid
distance
1.695
(17)
Å,
while
chelate
its
atoms
and,
together
Cl
ligand,
defines
‘legs’
stool.
Apart
from
Coulombic
forces,
C—H...F
and
C—H...Cl
hydrogen-bonding
interactions
consolidate
crystal
packing.
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Photoactivatable
metal
complexes
offer
the
prospect
of
novel
drugs
with
low
side
effects
and
new
mechanisms
action
to
combat
resistance
current
therapy.
We
highlight
recent
progress
in
design
platinum,
ruthenium,
iridium,
gold
other
transition
complexes,
especially
for
applications
as
anticancer
anti‐infective
agents.
In
particular,
understanding
excited
state
chemistry
related
identification
bioactive
species
(excited
metallomics/pharmacophores)
is
important.
metallodrugs
are
classified
here
photocatalysts,
photorelease
agents
ligand‐activated
Their
activation
wavelengths,
cellular
action,
experimental
theoretical
metallomics
states
photoproducts
discussed
explore
strategies
investigation
photoactivatable
metallodrugs.
These
have
potential
clinical
Photodynamic
Therapy
(PDT),
Photoactivated
Chemotherapy
(PACT)
Photothermal
(PTT).
Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Photoactivatable
metal
complexes
offer
the
prospect
of
novel
drugs
with
low
side
effects
and
new
mechanisms
action
to
combat
resistance
current
therapy.
We
highlight
recent
progress
in
design
platinum,
ruthenium,
iridium,
gold
other
transition
complexes,
especially
for
applications
as
anticancer
anti‐infective
agents.
In
particular,
understanding
excited
state
chemistry
related
identification
bioactive
species
(excited
metallomics/pharmacophores)
is
important.
metallodrugs
are
classified
here
photocatalysts,
photorelease
agents
ligand‐activated
Their
activation
wavelengths,
cellular
action,
experimental
theoretical
metallomics
states
photoproducts
discussed
explore
strategies
investigation
photoactivatable
metallodrugs.
These
have
potential
clinical
Photodynamic
Therapy
(PDT),
Photoactivated
Chemotherapy
(PACT)
Photothermal
(PTT).
Abstract
The
paradigm
of
cancer
treatment
has
been
shifting
from
traditional
approaches
to
metal-based
therapies;
however,
achieving
effective
and
targeted
treatments
remains
a
significant
challenge.
journey
drugs
began
with
the
serendipitous
discovery
cisplatin,
which
paved
way
for
development
various
platinum
derivatives.
Additionally,
other
metals,
such
as
ruthenium
(Ru),
nickel
(Ni),
zinc
(Zn),
copper
(Cu),
have
explored
their
therapeutic
potential.
Among
these,
ruthenium-based
complexes
stand
out
due
unique
redox
properties,
high
selectivity,
remarkable
chelation
capabilities,
making
them
promising
candidates
therapy.
This
Account
aims
provide
comprehensive
overview
metal
complexes,
current
status,
pharmacological
chemical
classification.
These
pharmacophores
enable
selective
delivery
cytotoxic
payloads
cells
while
sparing
healthy
cells.
Notably,
complex
IT-139
(formerly
NKP-1339)
demonstrated
promise
in
clinical
studies
types,
exhibiting
lower
toxicity
than
platinum-based
therapies.
also
highlights
advances.
It
readers
detailed
understanding
role
drug
development,
its
mechanisms
action,
potential
applications
personalized
treatments.
exploration
underscores
both
without
active
molecules,
emerge
safe
oncology.
1
Introduction
2
Importance
Ruthenium
Metal
Complexes
3
Synthesis
4
Classification
Complex
Antitumor
Drugs
Based
on
Mode
Action
5
Structure
Oxidation
State
6
Current
Status
Drug
Clinical
Trials
7
Applications
Metals
Other
8
Conclusion
RSC Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Organometallic
complexes
offer
a
wide
range
of
properties
like
structural
variety,
reaction
kinetics,
tunable
lipophilicity
and
alternate
mechanisms
activation
under
physiological
conditions
compared
to
platinum
chemotherapeutics
are
thus...
