Pseudomonas aeruginosa Vaccine Development: Lessons, Challenges, and Future Innovations
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2012 - 2012
Опубликована: Фев. 25, 2025
Pseudomonas
aeruginosa
is
an
opportunistic
pathogen
with
a
multidrug-resistant
profile
that
has
become
critical
threat
to
global
public
health.
It
one
of
the
main
causes
severe
nosocomial
infections,
including
ventilator-associated
pneumonia,
chronic
infections
in
patients
cystic
fibrosis,
and
bloodstream
immunosuppressed
individuals.
Development
vaccines
against
P.
major
challenge
owing
high
capacity
this
bacterium
form
biofilms,
its
wide
arsenal
virulence
factors
(including
secretion
systems,
lipopolysaccharides,
outer
membrane
proteins),
ability
evade
host
immune
system.
This
review
provides
comprehensive
historical
overview
vaccine
development
efforts
targeting
pathogen,
ranging
from
early
attempts
1970s
recent
advancements,
based
on
novel
proteins
emerging
technologies
such
as
nanoparticles
synthetic
conjugates.
Despite
numerous
promising
preclinical
developments,
very
few
candidates
have
progressed
clinical
trials,
none
achieved
final
approval.
panorama
highlights
significant
scientific
undertaken
inherent
complexity
successfully
developing
effective
aeruginosa.
Язык: Английский
Residue-Specific Protein-Glycan Conjugation Strategies for the Development of Pharmaceutically Promising Glycoconjugate Vaccines: A Recent Update
Carbohydrate Research,
Год журнала:
2025,
Номер
unknown, С. 109476 - 109476
Опубликована: Апрель 1, 2025
Язык: Английский
Chemical Synthesis and Antigenic Evaluation of Oligosaccharides of Bordetella hinzii O-Antigen Containing Unique Amidated 2,3-Diacetamido-2,3-dideoxy-alduronic Acids
JACS Au,
Год журнала:
2025,
Номер
5(4), С. 1903 - 1913
Опубликована: Апрель 16, 2025
Bordetella
hinzii
is
a
zoonotic
pathogen,
which
can
cause
brain
abscess,
pneumonia,
bacteremia,
and
urinary
tract
infection.
Vaccines
are
economical
effective
means
for
combating
infectious
diseases.
Herein,
we
present
the
first
total
synthesis
of
highly
functionalized
mono-
oligosaccharides
B.
O-antigen
vaccine
development.
The
rare
2,3-diacetamidopyranoses
were
generated
from
3-O-acetyl-2-nitroglycals
via
an
organocatalyzed
one-pot
relay
glycosylation
method.
postglycosylation
oxidation
strategy
was
used
to
overcome
poor
reactivity
2,3-diacetamido-aldouronic
acid
building
blocks
in
reactions.
Direct
amidation
alduronic
with
NH3
late
stage
reduced
protecting
group
operation
increased
synthetic
efficiency.
Di-tert-butylsilylidene-directed
α-galactosylation
method
construct
challenging
1,2-cis-glycosidic
bond.
Six
obtained
further
conjugated
human
serum
albumin
antigenicity
evaluation
(the
sera
antibodies
vaccinated
mouse
inactivated
hinzii).
terminal
tetrasaccharide
has
been
identified
as
potential
glycol-epitope
might
be
useful
development
against
hinzii.
Язык: Английский
Photolabile ortho‐Nitro‐Benzyl Carbonate as a Permanent Hydroxyl Protecting Group for the Synthesis of Digalactosyl Diacylglycerol
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 16, 2024
Comprehensive
Summary
Traditional
protecting
groups
are
often
removed
under
harsh
conditions
with
potentially
hazardous
reagents,
thereby
impeding
the
convenient
synthesis
of
oligosaccharides
and
glycosides.
Herein,
we
present
to
utilize
photolabile
ortho
‐nitro‐benzyl
carbonate
(
o
NBC)
as
a
permanent
hydroxyl
group
for
stereocontrolled
The
Ph
3
PO‐modulated
glycosylation
strongly
disarmed
per‐
O
‐
NBC‐protected
glycosyl
ynenoates
preferred
afford
glycosides
excellent
α‐selectivities
via
β‐phosphonium
transition
state.
Based
on
NBC‐mediated
galactosylation,
glycolipid
digalactosyl
diacylglycerol
(DGDG)
containing
six
double
bonds
two
esters
was
achieved
in
straightforward
manner.
Язык: Английский
Ph3PO-Modulated Kdo Glycosidation for Stereoselective Synthesis of β-Kdo-Containing Disaccharides
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 30, 2024
A
Ph3PO-modulated
β-selective
Kdo
glycosidation
approach
is
developed
for
the
stereoselective
synthesis
of
β-Kdo
glycosides.
With
readily
available
per-O-acetylated
ynenoate
as
donor,
glycosylation
with
a
series
alcohols
in
presence
Ph3PAuOTf
and
Ph3PO
toluene
at
low
temperatures
afforded
desired
glycosides
good
to
excellent
β-selectivities.
Furthermore,
was
effectively
applied
β-(2→4)-
β-(2→8)-linked
Kdo-Kdo
disaccharides
further
biological
studies.
Язык: Английский