Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Сен. 3, 2024
Abstract
Controlling
the
succession
of
chemical
processes
with
high
specificity
in
complex
systems
is
advantageous
for
widespread
applications,
from
biomedical
research
to
drug
manufacturing.
Despite
synthetic
advances
bioorthogonal
and
photochemical
methodologies,
there
a
need
generic
approaches
that
can
universally
modulate
photodynamic
reactivity
organic
photosensitizers.
Herein
we
present
strategy
fine-tune
production
singlet
oxygen
multiple
photosensitive
scaffolds
under
activation
bioresponsive
stimuli.
We
demonstrate
photocatalytic
activity
nitrobenzoselenadiazoles
be
fully
blocked
by
site-selective
incorporation
electron-withdrawing
carbamate
moieties
restored
on
demand
upon
uncaging
wide
range
molecular
triggers,
including
abiotic
transition-metal
catalysts.
also
prove
this
expanded
most
photosensitizers,
diverse
structures
spectral
properties.
Finally,
show
such
advanced
control
generation
broadly
applied
ablation
human
cells
as
well
regulate
release
semi-synthesis
natural
product
drugs.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(5), С. 1795 - 1835
Опубликована: Янв. 1, 2022
The
discovery
of
a
near-infrared
(NIR,
650-900
nm)
fluorescent
chromophore
hemicyanine
dye
with
high
structural
tailorability
is
great
significance
in
the
field
detection,
bioimaging,
and
medical
therapeutic
applications.
It
exhibits
many
outstanding
advantages
including
absorption
emission
NIR
region,
tunable
spectral
properties,
photostability
as
well
large
Stokes
shift.
These
properties
are
superior
to
those
conventional
fluorogens,
such
coumarin,
fluorescein,
naphthalimides,
rhodamine,
cyanine.
Researchers
have
made
remarkable
progress
developing
activity-based
multifunctional
probes
based
on
skeletons
for
monitoring
vital
biomolecules
living
systems
through
output
fluorescence/photoacoustic
signals,
integration
diagnosis
treatment
diseases
using
chemotherapy
or
photothermal/photodynamic
therapy
combination
therapy.
achievements
prompted
researchers
develop
more
smart
fluorogen
template.
In
this
review,
we
begin
by
describing
brief
history
dyes,
synthetic
approaches,
design
strategies
functional
probes.
Then,
selected
hemicyanine-based
that
can
detect
ions,
small
biomolecules,
overexpressed
enzymes
diagnostic
reagents
systematically
highlighted.
Finally,
potential
drawbacks
outlook
future
investigation
clinical
medicine
transformation
activatable
also
discussed.
Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Май 19, 2024
The
emergence
of
multidrug
resistant
(MDR)
pathogens
and
the
scarcity
new
potent
antibiotics
antifungals
are
one
biggest
threats
to
human
health.
Antimicrobial
photodynamic
therapy
(aPDT)
combines
light
photosensitizers
kill
drug-resistant
pathogens;
however,
there
limited
materials
that
can
effectively
ablate
different
classes
infective
pathogens.
In
present
work,
a
class
benzodiazole-paired
is
designed
as
highly
PDT
agents
with
broad-spectrum
antimicrobial
activity
upon
illumination
nontoxic
light.
results
mechanistically
demonstrate
energy
transfer
electron
between
nonphotosensitive
photosensitive
benzodiazole
moieties
embedded
within
pathogen-binding
peptide
sequences
result
in
increased
singlet
oxygen
generation
enhanced
phototoxicity.
Chemical
optimization
renders
PEP3
novel
agent
remarkable
against
MDR
bacteria
fungi
well
at
stages
development
(e.g.,
biofilms,
spores,
fungal
hyphae),
which
also
prove
effective
an
ex
vivo
porcine
model
microbial
keratitis.
chemical
modularity
this
strategy
its
general
compatibility
peptide-based
targeting
will
accelerate
design
for
PDT.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(6), С. 2081 - 2120
Опубликована: Янв. 1, 2022
From
a
chemistry-based
perspective,
this
review
discusses
the
most
recent
advances
in
field
of
substrate-based
probes
for
detection
and
analysis
proteolytic
activity
both
vitro
vivo
.
Chemical Communications,
Год журнала:
2023,
Номер
59(21), С. 3040 - 3049
Опубликована: Янв. 1, 2023
Stimuli-responsive
fluorescent
probes
have
been
widely
utilized
in
detecting
the
physiological
and
pathological
states
of
living
systems.
Numerous
stimuli-responsive
developed
due
to
their
advantages
good
sensitivity,
high
resolution,
contrast
signals.
In
this
feature
article,
progress
multi-stimuli-responsive
probes,
including
organic
molecules
metal
complexes,
for
detection
various
biomarkers
bio-applications
is
summarized.
The
article
focuses
on
applications
organic-molecule-
metal-complex-based
molecular
biological
systems
different
cancer
or
other
diseases.
current
challenges
potential
future
directions
these
are
also
discussed.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(16), С. 5352 - 5372
Опубликована: Янв. 1, 2023
T
cells
are
an
essential
component
of
the
immune
system
and
display
multiple
biological
functions.
Smart
probes
range
from
small
fluorophores
to
nanoconstructs,
can
target
metabolic
enzymatic
biomarkers
as
well
cell-surface
receptors.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(30)
Опубликована: Май 8, 2024
Abstract
Photodynamic
therapy
is
an
anti‐cancer
treatment
that
requires
illumination
of
photosensitizers
to
induce
local
cell
death.
Current
near‐infrared
organic
are
built
from
large
and
non‐modular
structures
cannot
be
tuned
improve
safety
minimize
off‐target
toxicity.
This
work
describes
a
novel
chemical
platform
generate
enzyme‐activatable
photosensitizers.
We
optimized
the
Se‐bridged
hemicyanine
scaffold
include
caging
groups
biocompatible
moieties,
generated
cathepsin‐triggered
for
effective
ablation
human
glioblastoma
cells.
Furthermore,
we
demonstrated
hemicyanines
safe
microtumors
in
vivo,
creating
new
avenues
design
targeted
photodynamic
agents.
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Small
molecule
near-infrared
(NIR)
fluorophores
play
a
critical
role
in
disease
diagnosis
and
early
detection
of
various
markers
living
organisms.
To
accelerate
their
development
design,
deep
learning
platform,
NIRFluor,
was
established
to
rapidly
screen
small
NIR
with
the
desired
optical
properties.
The
core
component
NIRFluor
is
state-of-the-art
model
trained
on
5179
experimental
big
data.
First,
novel
hybrid
fingerprints
including
Morgan
fingerprints,
physicochemical
properties,
solvent
properties
were
proposed.
Then,
powerful
model,
multitask
fingerprint-enhanced
graph
convolutional
network
(MT-FinGCN),
designed,
which
combines
fingerprint
information
structure
achieve
accurate
prediction
six
(absorption
wavelength,
emission
Stokes
shift,
extinction
coefficient,
photoluminescence
quantum
yield,
lifetime)
different
solvents.
Furthermore,
"black-box"
GCN
opened
through
interpretability
studies.
Finally,
well-trained
models
placed
web
platform
for
free
use
(https://nirfluor.aicbsc.com).
