Engineered platelets as targeted protein degraders and application to breast cancer models

Nature Biotechnology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Язык: Английский

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N-Acyl-N-alkyl/aryl Sulfonamide Chemistry Assisted by Proximity for Modification and Covalent Inhibition of Endogenous Proteins in Living Systems

Accounts of Chemical Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

ConspectusSelective chemical modification of endogenous proteins in living systems with synthetic small molecular probes is a central challenge biology. Such has variety applications important for biological and pharmaceutical research, including protein visualization, functionalization, proteome-wide profiling enzyme activity, irreversible inhibition activity. Traditional chemistry selective cells largely relies on the high nucleophilicity cysteine residues to ensure target-selectivity site-specificity modification. More recently, lysine residues, which are more abundant surfaces, have attracted attention covalent proteins. However, it been difficult efficiently modify ε-amino groups side-chains, mostly (∼99.9%) protonated thus exhibit low at physiological pH. Our group revealed that

Язык: Английский

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Covalent functionalization of G protein-coupled receptors by small molecular probes

RSC Chemical Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

In this review, we take a closer look at the most recent small molecular probes that covalently label G protein-coupled receptors.

Язык: Английский

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Ligand-directed covalent labelling of adenosine receptors

Purinergic Signalling, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Язык: Английский

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A modular click ligand-directed approach to label endogenous dopamine D1 receptors in live cells

Communications Chemistry, Год журнала: 2025, Номер 8(1)

Опубликована: Апрель 11, 2025

Язык: Английский

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