DNA and Cell Biology,
Год журнала:
2023,
Номер
42(12), С. 746 - 752
Опубликована: Окт. 16, 2023
Long
noncoding
RNAs
(lncRNAs)
have
been
implicated
in
coronary
artery
disease
(CAD)
processes.
However,
the
relationship
between
gene
polymorphisms
of
lncRNA
RP1-276N6.2
as
a
novel
molecule
and
susceptibility
to
CAD
remains
unclear.
In
our
case-control
study,
949
patients
892
healthy
controls
were
genotyped
using
TaqMan
genotyping
assay.
The
quantitative
real-time
polymerase
chain
reaction
enzyme-linked
immunosorbent
assay
performed
examine
expression
levels
SLC22A3(OCT3).
We
observed
that
had
significantly
lower
than
those
participants
(
Cells,
Год журнала:
2024,
Номер
13(12), С. 1063 - 1063
Опубликована: Июнь 19, 2024
Neurological
and
neuropsychiatric
disorders
pose
substantial
challenges
to
public
health,
necessitating
a
comprehensive
understanding
of
the
molecular
mechanisms
underlying
their
pathogenesis.
In
recent
years,
focus
has
shifted
toward
intricate
world
non-coding
RNAs
(ncRNAs),
class
RNA
molecules
that
do
not
encode
proteins
but
play
pivotal
roles
in
gene
regulation
cellular
processes.
This
review
explores
emerging
significance
ncRNAs
context
neurological
disorders,
shedding
light
on
diverse
functions
regulatory
mechanisms.
The
dysregulation
various
ncRNAs,
including
microRNAs
(miRNAs),
long
(lncRNAs),
circular
(circRNAs),
been
implicated
pathophysiology
conditions
such
as
Alzheimer’s
disease,
Parkinson’s
schizophrenia,
mood
disorders.
delves
into
specific
these
modulating
key
processes,
synaptic
plasticity,
neuroinflammation,
apoptosis,
providing
nuanced
impact
disease
progression.
Furthermore,
it
discusses
potential
diagnostic
therapeutic
implications
targeting
identification
ncRNA
signatures
holds
promise
for
development
novel
biomarkers
early
detection,
while
manipulation
expression
offers
innovative
avenues.
Challenges
future
directions
field
are
also
considered,
highlighting
need
continued
research
unravel
complexities
ncRNA-mediated
networks
aims
provide
overview
current
state
knowledge
stimulate
further
exploration
fascinating
realm
brain’s
landscape.
Clinical Rheumatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 11, 2025
Abstract
The
current
study
was
deployed
to
evaluate
the
role
of
metastasis-associated
lung
adenocarcinoma
transcript
1
(MALAT1)
and
miR-155,
along
with
inflammatory
markers,
TNFα
IL-6,
adhesion
molecule,
cluster
differentiation
106
(CD106),
in
Behçet’s
disease
(BD)
pathogenesis.
also
assessed
MALAT1/miR-155
as
promising
diagnostic
prognostic
biomarkers
for
BD.
retrospective
case–control
included
74
Egyptian
BD
patients
50
age
sex-matched
controls.
Blood
samples
were
collected,
then,
serum
separated
further
biochemical
molecular
investigations.
gene
expression
MALAT1
miR-155
measured
using
qRT-PCR,
whereas
levels
TNFα,
CD106
estimated
ELISA
technique.
significantly
downregulated,
upregulated
among
patients,
compared
control
subjects.
Levels
elevated
patients.
Further
downregulation
together
upregulation
observed
active
relative
inactive
group.
Receiver-operating-characteristic
analysis
revealed
that
could
discriminate
from
controls,
on
one
hand,
other
hand.
negatively
correlated
CD106,
while
positively
them.
Logistic
regression
analyses
demonstrated
a
significant
independent
predictor
susceptibility,
an
negative
activity.
For
first
time,
research
enlightens
pathogenesis
via
impacting
IL-6/TNF-α/CD-106
signaling.
As
well,
be
regarded
novel
non-invasive
may
improve
diagnosis
prognosis.
Key
Points
•MALAT1/miR-155
exerts
potential
disease.
are
targets
BMC Cardiovascular Disorders,
Год журнала:
2022,
Номер
22(1)
Опубликована: Апрель 7, 2022
Metastasis-associated
lung
adenocarcinoma
transcript
1
(MALAT1)
participates
in
the
occurrence
and
development
of
cardiovascular
cerebrovascular
diseases
such
as
stroke
coronary
heart
disease
by
regulating
inflammatory
reactions,
programmed
cell
death,
other
pathological
processes.
Previous
studies
revealed
that
MALAT1
gene
polymorphism
was
associated
with
cardiac
diseases.
However,
prognostic
role
major
adverse
events
(MACCEs)
remains
unknown.
Therefore,
this
study
intends
to
explore
association
between
rs3200401
MACCEs.We
enrolled
617
myocardial
infarction
(MI)
patients
1125
control
participants
who
attended
First
Affiliated
Hospital
Xinjiang
Medical
University
from
January
2010
2018.
SNPscan™
typing
assays
were
used
detect
genotype.
During
follow-up,
MACCEs
recorded.
Kaplan-Meier
curves
univariate
multivariate
Cox
survival
analyses
correlation
polymorphisms
MACCEs.Among
total
MI
patients,
frequencies
T
allele
(total
Participants
19.5%
vs.
15.3%,
P
=
0.047,
20.7%
14.1%,
0.014)
CT
+
TT
genotypes
37.4%
28.1%,
0.013,
39.5%
25.8%,
0.003)
significantly
higher
subjects
than
without
MACCEs.
participants,
(16.6%
16.0%,
0.860)
(31.4%
29.3%,
0.760)
not
In
addition,
among
curve
analysis
indicated
had
a
incidence
CC
genotype
carriers
(P
0.015,
0.001).
Nevertheless,
similar
results
observed
0.790).
Multivariate
regression
compared
genotype,
1.554-fold
increase
MACCE
risk
(hazard
ratio:
1.554,
95%
confidence
interval:
1.060-2.277,
0.024).The
could
be
factor
for
suggesting
may
become
biomarker
poor
prognosis
patients.
Cardiology Research and Cardiovascular Medicine,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 8, 2024
Despite
all
current
efforts
in
the
field
of
cerebrovascular
disease
prevention,
stroke
remains
leading
cause
disability
and
death
worldwide.
Animal
models
are
essential
tools
research
to
mitigate
its
devastating
effects.
The
novelty
this
review
is
comprehensiveness
approach
detailed
analysis
progress
field,
translational
potential
clinical
relevance.
Recent
aimed
refine
enhance
animal
better
mimic
scenario
improve
reproducibility.
This
provides
extensive
overview
classification,
underlining
their
key
features,
advantages,
limitations,
advancements.
Additionally,
characterization
validation
ischemia
discussed.
Therapeutic
strategies
such
as
hypothermia,
pharmacological
interventions,
genetic
molecular
approaches,
cell-based
therapies
highlighted.
analyse
challenges
future
directions,
well
relevance
models.
Incorporating
patient-derived
cells
modifications
can
provide
a
more
personalized
clinically
relevant
approach.
Bridging
gap
challenging
requires
careful
consideration
multiple
factors,
including
appropriate
dose
translation,
understanding
species
differences,
aligning
protocols.
Future
studies
should
focus
on
optimizing
process
conducting
well-designed
trials
assess
safety
efficacy
promising
interventions.
Frontiers in Genetics,
Год журнала:
2022,
Номер
12
Опубликована: Янв. 12, 2022
Background:
Acute
ischemic
stroke
(AIS)
is
the
second
leading
cause
of
death
and
third
disability
worldwide.
Long
noncoding
RNAs
(lncRNAs)
are
promising
biomarkers
for
early
diagnosis
AIS
closely
participate
in
mechanism
onset.
However,
studies
focusing
on
lncRNAs
functioning
as
microRNA
(miRNA)
sponges
to
regulate
mRNA
expression
rare
superficial.
Methods:
In
this
study,
we
systematically
analyzed
profiles
lncRNA,
(GSE58294),
miRNA
(GSE110993)
from
GEO
database.
Gene
ontology
(GO)
analysis
was
performed
reveal
functions
differentially
expressed
genes
(DEGs),
used
weighted
gene
co-expression
network
(WGCNA)
investigate
relationships
between
clinical
features
lncRNA.
Finally,
constructed
a
lncRNA-miRNA-mRNA
competing
endogenous
RNA
(ceRNA)
with
selected
DEGs
using
bioinformatics
methods
obtained
ROC
curves
assess
diagnostic
efficacy
(DElncRNAs)
mRNAs
(DEmRNAs)
our
network.
The
GSE22255
dataset
confirm
value
candidate
genes.
Results:
total,
199
DElncRNAs,
2068
DEmRNAs,
96
miRNAs
were
detected.
GO
revealed
that
DEmRNAs
primarily
neutrophil
activation,
degranulation,
vacuolar
transport,
lysosomal
transport.
WGCNA
screened
out
16
195
DEGs,
only
eight
DElncRNAs
maintained
an
area
under
curve
higher
than
0.9.
By
investigating
mRNAs,
ceRNA
containing
three
lncRNAs,
miRNAs,
seven
constructed.
confirmed
RP1-193H18.2
more
advantageous
diagnosing
stroke,
whereas
no
showed
realistic
efficacy.
Conclusion:
may
broaden
understanding
pathology,
lncRNA
assumed
be
therapeutic
target
biomarker
AIS.
