Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease
Cells,
Год журнала:
2025,
Номер
14(3), С. 168 - 168
Опубликована: Янв. 22, 2025
The
recent
approval
of
lecanemab
highlights
that
the
amyloid
beta
(Aβ)
protein
is
an
important
pathological
target
in
Alzheimer’s
disease
(AD)
and
further
emphasizes
significance
neuroinflammatory
pathways
regulating
Aβ
accumulation.
Indeed,
accumulation
triggers
microglia
activation,
which
are
key
mediators
neuroinflammation.
inflammatory
responses
this
process
can
lead
to
neuronal
damage
functional
decline.
Microglia
secrete
proinflammatory
cytokines
accelerate
death
release
anti-inflammatory
growth
factors
contributing
recovery
protection.
Thus,
play
a
dual
role
neurodegeneration
neuroprotection,
complicating
their
function
AD.
Therefore,
elucidating
complex
interactions
between
protein,
microglia,
neuroinflammation
essential
for
developing
new
strategies
treating
This
review
investigates
receptors
involved
activating
aims
enhance
understanding
how
these
processes
impact
AD,
as
well
they
be
regulated.
also
analyzed
studies
reported
existing
literature
ongoing
clinical
trials.
Overall,
will
contribute
regulatory
mechanisms
therapies
slow
progression
Язык: Английский
Investigating the Potential Therapeutic Targeting of the JAK-STAT Pathway in Cerebrovascular Diseases: Opportunities and Challenges
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Язык: Английский
Pharmacological mechanisms of puerarin in the treatment of Parkinson's disease: An overview
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117101 - 117101
Опубликована: Июль 14, 2024
Puerarin,
a
monomer
of
traditional
Chinese
medicine,
is
key
component
Pueraria
radix.
Both
clinical
and
experimental
researches
demonstrated
that
puerarin
has
therapeutic
effects
on
Parkinson's
disease
(PD).
Puerarin's
pharmacological
mechanisms
include:
1)
Anti-apoptosis.
Puerarin
inhibits
cell
apoptosis
through
the
phosphatidylinositol-4,5-bisphosphate
3-kinase
(PI3K)/protein
kinase
B
(Akt)
c-Jun
N-terminal
(JNK)
signaling
pathways.
also
exerts
hormone-like
effect
against
apoptosis;
2)
Anti-oxidative
stress
injury.
Nrf2
nuclear
exclusion
GSK-3β/Fyn
pathway
to
promote
accumulation
in
nucleus,
then
promotes
antioxidant
synthesis
Nrf2/ARE
protect
oxidative
stress;
3)
Neuroprotective
by
intervening
ubiquitin-proteasome
system
(UPS)
autophagy-lysosomal
(ALP).
significantly
enhances
activity
chaperone-mediated
autophagy
(CMA),
which
downregulates
expression
α-synuclein,
reduces
its
accumulation,
thus
improves
function
damaged
neurons.
Additionally,
increases
proteasome
decreases
ubiquitin-binding
proteins,
thereby
preventing
toxic
intracellular
proteins;
4)
Alleviating
inflammatory
response.
conversion
microglia
M1
phenotype
while
inducing
transition
M2
phenotype.
Furthermore,
secretion
anti-inflammatory
factor
pro-inflammatory
factors;
5)
Increasing
levels
dopamine
metabolites.
could
increase
dopamine,
homovanillic
acid
(HVA)
3,4-dihydroxyphenylacetic
(DOPAC)
striatum;
6)
Promoting
neurotrophic
neuronal
repair.
glial
cell-derived
(GDNF),
brain-derived
(BDNF)
nerve
growth
(NGF),
exerting
neuroprotective
effect.
Moreover,
regulation
gut
microbiota
may
be
potential
mechanism
for
treatment
PD.
The
current
review
discusses
molecular
puerarin,
provide
insight
into
active
components
medicine
Язык: Английский
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice
Acta Pharmacologica Sinica,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 30, 2024
Язык: Английский
Testing the Simplified Molecular Dynamics Approach to Improve the Reproduction of ECD Spectra and Monitor Aggregation
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6453 - 6453
Опубликована: Июнь 12, 2024
A
simplified
molecular-dynamics-based
electronic
circular
dichroism
(ECD)
approach
was
tested
on
three
condensed
derivatives
with
limited
conformational
flexibility
and
an
isochroman-2H-chromene
hybrid,
the
ECD
spectra
of
which
could
not
be
precisely
reproduced
by
conventional
calculation
protocol.
Application
explicit
solvent
molecules
at
molecular
mechanics
(MD)
level
in
dynamics
simulations
subsequent
TDDFT-ECD
for
unoptimized
MD
structures
able
to
improve
agreements
between
experimental
computed
spectra.
Since
enhancements
were
achieved
even
flexibility,
deformations
caused
multitudes
conformers
produced
geometries
seem
key
factors
better
agreement.
The
confirm
that
aggregation
phenanthrene
natural
product
luzulin
had
a
significant
contribution
specific
wavelength
range
ECD.
has
proved
dimer
formation
occurred
solution
this
responsible
anomalous
spectrum.
scope
limitations
method
have
also
been
discussed.
Язык: Английский
Pantothenic acid-mediated inhibition of microglial inflammation via the JAK2/STAT3 pathway enhances motor function recovery after Spinal cord injury
Yuepeng Fang,
Ce Zhang,
Zhijie Yang
и другие.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
Abstract
This
study
employed
transcriptome
sequencing
and
targeted
metabolomics
to
delve
into
the
molecular
alterations
in
mouse
spinal
cords
following
cord
injury
(SCI).
Notably,
a
significant
depletion
of
pantothenic
acid
(PA)
was
observed
injured
cord,
exhibiting
an
inverse
correlation
with
microglial
inflammation
activation.
To
further
elucidate
this
relationship,
experimental
interventions
using
PA
were
conducted
SCI
models.
The
results
demonstrated
that
administration
effectively
inhibited
via
modulation
JAK2/STAT3
signaling
pathway.
inhibition
not
only
mitigated
neuroinflammatory
milieu
but
also
fostered
environment
conducive
axonal
growth
neuronal
regeneration.
Consequently,
mice
treated
exhibited
improved
motor
function
recovery
compared
untreated
controls.
Our
findings
deepen
understanding
relationship
between
processes
highlight
therapeutic
potential
promoting
regeneration
functional
recovery.
Язык: Английский
Heme oxygenase-1: potential therapeutic targets for periodontitis
PeerJ,
Год журнала:
2024,
Номер
12, С. e18237 - e18237
Опубликована: Окт. 15, 2024
Periodontitis
is
one
of
the
most
prevalent
inflammatory
disease
worldwide,
which
affects
11%
global
population
and
a
major
cause
tooth
loss.
Recently,
oxidative
stress
(OS)
has
been
found
to
be
pivital
pathophysiological
mechanism
periodontitis,
overactivated
OS
will
lead
inflammation,
apoptosis,
pyroptosis
alveolar
bone
resorption.
Interestingly,
heme
oxygenase-1
(HO-1),
rate-limiting
enzyme
in
degradation,
can
exert
antioxidant
activites
through
its
products-carbon
monoxide
(CO),
Fe
Язык: Английский