Российский физиологический журнал им И М Сеченова,
Год журнала:
2024,
Номер
110(9), С. 1294 - 1315
Опубликована: Дек. 13, 2024
The
serotoninergic
system
plays
an
essential
role
in
the
modulation
of
spinal
networks
activity
involved
control
motor,
sensory,
and
visceral
functions.
Spinal
cord
injury
(SCI)
can
induce
a
state
overexcitation
that
contributes
to
pain,
spasticity,
dysregulation
autonomic
At
same
time,
5-NT
axons
are
known
adapt
faster
than
others
pathophysiologic
changes
leave
ability
sprout
regenerate
after
injury.
A
number
experimental
animal
studies
as
well
some
clinical
observations
suggest
is
key
endogenous
resource
for
posttraumatic
recovery
SCI.
Specific
therapy
may
include
administration
drugs
intraspinal
transplantation
neurons.
This
review
discusses
functional
SCI
prospects
use
neurorehabilitation.
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(8), С. 1702 - 1711
Опубликована: Март 4, 2024
Serotonin-releasing
fibers
depart
from
the
raphe
nuclei
to
profusely
innervate
entire
central
nervous
system,
displaying
in
some
brain
regions
high
structural
plasticity
response
genetically
induced
abrogation
of
serotonin
synthesis.
Chronic
fluoxetine
treatment
used
as
a
tool
model
peri-physiological,
clinically
relevant
elevation
is
also
able
cause
rearrangements
serotonergic
innervating
hippocampus.
Whether
this
effect
limited
hippocampal-innervating
or
extends
other
populations
axons
not
known.
Here,
we
confocal
imaging
and
three-dimensional
(3-D)
modeling
analysis
expand
our
morphological
investigation
fluoxetine-mediated
effects
on
circuitry.
We
found
that
chronic
with
behaviorally
active
dose
affects
morphology
reduces
density
medial
prefrontal
cortex,
region
strongly
implicated
regulation
depressive-
anxiety-like
behavior.
Axons
somatosensory
cortex
were
unaffected,
suggesting
differential
susceptibility
changes
across
cortical
areas.
Importantly,
1-month
washout
period
was
sufficient
reverse
both
previously
characterized
hippocampus,
well
normalize
behavior,
highlighting
an
intriguing
relationship
between
axon
antidepressant-like
effect.
Overall,
these
results
further
demonstrate
bidirectional
defined
provide
additional
insights
into
system.
The Neuroscientist,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 11, 2024
Almost
every
facet
of
our
behavior
and
physiology
varies
predictably
over
the
course
day
night,
anticipating
adapting
us
to
their
associated
opportunities
challenges.
These
rhythms
are
driven
by
endogenous
biological
clocks
that,
when
deprived
environmental
cues,
can
continue
oscillate
within
a
period
approximately
1
day,
hence
circa-
dian.
Normally,
retinal
signals
synchronize
them
cycle
light
darkness,
but
disruption
circadian
organization,
common
feature
modern
lifestyles,
carries
considerable
costs
health.
Circadian
timekeeping
pivots
around
cell-autonomous
molecular
clock,
widely
expressed
across
tissues.
cellular
timers
in
turn
synchronized
principal
clock
brain:
hypothalamic
suprachiasmatic
nucleus
(SCN).
Intercellular
make
SCN
network
very
powerful
pacemaker.
Previously,
neurons
were
considered
sole
timekeepers,
with
glial
cells
playing
supportive
roles.
New
discoveries
have
revealed,
however,
that
astrocytes
active
partners
timekeeping,
regulating
extracellular
glutamate
GABA
concentrations
control
cycles
neuronal
activity.
Here,
we
introduce
at
levels
before
focusing
on
contributions
mutual
interaction
brain.
European Journal of Neuroscience,
Год журнала:
2024,
Номер
60(5), С. 5019 - 5039
Опубликована: Авг. 5, 2024
Modulation
of
input
from
primary
afferent
fibres
has
long
been
examined
at
the
level
first
relays
these
fibres.
However,
recent
studies
reveal
that
to
spinal
cord
may
also
be
modulated
very
entry
grey
matter
before
action
potentials
in
intraspinal
collaterals
reach
their
target
neurons.
Such
modulation
greatly
depends
on
actions
GABA
via
extrasynaptic
membrane
receptors.
In
reported
study
we
hypothesized
increase
excitability
following
epidural
polarization
close
site
where
leave
dorsal
columns
is
due
release
two
sources:
not
only
GABAergic
interneurons
but
glial
cells.
We
present
evidence,
primo,
released
both
sources
contributes
a
long-lasting
and
shortening
refractory
period
epidurally
stimulated
and,
secondo,
effects
are
more
critical
for
changes
than
direct
DC
The
experiments
were
carried
out
deeply
anaesthetized
rats
which
compound
evoked
hindlimb
peripheral
nerves
by
column
stimulation
used
as
measure
throws
new
light
networks
mechanisms
underlying
restoration
functions.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 4, 2024
ABSTRACT
Modulation
of
input
from
primary
afferent
fibres
has
long
been
examined
at
the
level
first
relay
neurons
these
fibres.
However,
recent
studies
reveal
that
to
spinal
cord
may
also
be
modulated
before
action
potentials
in
intraspinal
collaterals
reach
their
target
neurons,
even
very
entry
grey
matter.
Such
modulation
greatly
depends
on
actions
GABA
via
extrasynaptic
membrane
receptors.
In
reported
study
we
hypothesized
increase
excitability
following
epidural
polarization
close
site
where
leave
dorsal
columns
is
due
release
two
sources:
not
only
terminals
GABAergic
interneurons
but
glial
cells.
We
present
evidence,
primo,
both
sources
contributes
a
long-lasting
and
shortening
refractory
period
epidurally
stimulated
afferents
and,
secondo,
effects
GABA-containing
cells
are
more
critical
for
changes
than
direct
The
experiments
were
carried
out
deeply
anaesthetized
rats
which
compound
evoked
hindlimb
peripheral
nerves
by
column
stimulation
used
as
measure
throws
new
light
networks
mechanisms
underlying
restoration
functions.
ACS Medicinal Chemistry Letters,
Год журнала:
2024,
Номер
15(2), С. 171 - 173
Опубликована: Янв. 23, 2024
This
Patent
Highlight
explores
the
emerging
role
of
5-HT2A
receptor
modulators
and
psychoplastogens
in
neuropsychiatric
treatment.
It
delves
into
these
novel
compounds'
molecular
mechanisms,
therapeutic
potential,
challenges,
highlighting
their
potential
mental
health
care.
The Anatomical Record,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 27, 2024
Abstract
The
present
study
reexamined
the
immunolocalization
of
membranous
serotonin
transporter
(SERT)
in
rat
carotid
body,
and
demonstrated
SERT‐immunoreactive
cells
unreported
morphology.
SERT
was
immunohistochemically
localized
a
very
small
population
cell
clusters
or
single
type
I
(2.8%)
immunoreactive
for
synaptophysin,
marker
these
cells.
Intense
immunoreactivity
outlined
perinuclear
cytoplasm
multiple
cytoplasmic
processes
Of
cells,
14.6%
32.6%
were
tyrosine
hydroxylase
(TH)
dopamine
beta‐hydroxylase,
respectively,
while
75.9%
(5‐HT).
5‐HT‐immunoreactive
products
bodies
rather
than
processes.
composed
an
oval
body
with
threads
spherical
elongated
Clusters
between
attached
to
other
TH‐immunoreactive
by
variform
mainly
contained
bassoon‐immunoreactive
their
These
results
characteristic
morphology
which
extend
terminal
parts.
Their
might
be
suitable
uptake
5‐HT
control
serotonergic
modulation
body.
Российский физиологический журнал им И М Сеченова,
Год журнала:
2024,
Номер
110(9), С. 1294 - 1315
Опубликована: Дек. 13, 2024
The
serotoninergic
system
plays
an
essential
role
in
the
modulation
of
spinal
networks
activity
involved
control
motor,
sensory,
and
visceral
functions.
Spinal
cord
injury
(SCI)
can
induce
a
state
overexcitation
that
contributes
to
pain,
spasticity,
dysregulation
autonomic
At
same
time,
5-NT
axons
are
known
adapt
faster
than
others
pathophysiologic
changes
leave
ability
sprout
regenerate
after
injury.
A
number
experimental
animal
studies
as
well
some
clinical
observations
suggest
is
key
endogenous
resource
for
posttraumatic
recovery
SCI.
Specific
therapy
may
include
administration
drugs
intraspinal
transplantation
neurons.
This
review
discusses
functional
SCI
prospects
use
neurorehabilitation.
