Astrocyte Mitochondria Are a Sensitive Target of PCB52 and its Human-Relevant Metabolites

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(15), С. 2729 - 2740

Опубликована: Июль 2, 2024

Polychlorinated biphenyls (PCBs) are industrial chemicals that ubiquitously found in the environment. Exposure to these compounds has been associated with neurotoxic outcomes; however, underlying mechanisms for such outcomes remain be fully understood. Recent studies have shown astrocytes, most abundant glial cell type brain, susceptible PCB exposure as well human-relevant metabolites of PCBs. Astrocytes critical maintaining healthy brain function due their unique functional attributes and positioning within neuronal networks brain. In this study, we assessed toxicity PCB52, one abundantly congeners outdoor indoor air, two its metabolites, on astrocyte mitochondria. We exposed C6 cells, an line, PCB52 or all showed increased galactose-containing media compared glucose-containing media, indicating involvement mitochondria observed toxicity. Additionally, also oxidative stress upon metabolites. All three caused a loss mitochondrial membrane potential, distinct changes structure, impaired function. The hydroxylated metabolite 4-OH-PCB52 likely functions uncoupler This is first study report adverse effects structure astrocytes.

Язык: Английский

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Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137688 - 137688

Опубликована: Фев. 20, 2025

Язык: Английский

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Subacute Exposure of Male Adolescent Rats to 2,2',5,5'-Tetrachlorobiphenyl-4-ol via a Polymeric Implant Causes Gene Expression Changes in the Brain and Metabolomic Disruption in Serum

Toxicology, Год журнала: 2025, Номер unknown, С. 154120 - 154120

Опубликована: Март 1, 2025

Язык: Английский

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Upregulation of fatty acid synthesis genes in the livers of adolescent female rats caused by inhalation exposure to PCB52 (2,2′,5,5′-Tetrachlorobiphenyl)

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 110, С. 104520 - 104520

Опубликована: Июль 26, 2024

Язык: Английский

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Interactions of Polychlorinated Biphenyls and Their Metabolites with the Brain and Liver Transcriptome of Female Mice

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(21), С. 3991 - 4009

Опубликована: Окт. 11, 2024

Exposure to polychlorinated biphenyls (PCBs) is linked neurotoxic effects. This study aims close knowledge gaps regarding the specific modes of action PCBs in female C57BL/6J mice (>6 weeks) orally exposed for 7 weeks a human-relevant PCB mixture (MARBLES mix) at 0, 0.1, 1, and 6 mg/kg body weight/day. hydroxylated (OH-PCBs) levels were quantified brain, liver, serum; RNA sequencing was performed striatum, prefrontal cortex, metabolomic analyses striatum. Profiles but not their metabolites similar all tissues. In exposure activated oxidative phosphorylation respiration pathways, while suppressing axon guidance pathway. significantly changed expression genes associated with neurodevelopmental neurodegenerative diseases impacting pathways like growth hormone synthesis dendrite development. did affect striatal metabolome. contrast which showed activation metabolic processes following induction cytochrome P450 enzymes, xenobiotic processing altered by either brain region. Network analysis revealed complex interactions between individual (e.g., PCB28 [2,4,4′-trichlorobiphenyl]) differentially expressed (DEGs), underscoring need characterize association DEGs. These findings enhance understanding mechanisms potential implications human health.

Язык: Английский

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aInhalation of 2,2’,5,5’-Tetrachlorobiphenyl (PCB52) Causes Changes to the Gut Microbiome Throughout the Gastrointestinal Tract

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 135999 - 135999

Опубликована: Окт. 1, 2024

Язык: Английский

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Effects of 28-Day Nose-Only Inhalation of PCB52 (2,2',5,5'-Tetrachlorobiphenyl) on the Brain Transcriptome

Toxicology, Год журнала: 2024, Номер unknown, С. 153965 - 153965

Опубликована: Окт. 1, 2024

Язык: Английский

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Exposure to PCB52 (2,2′,5,5′-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 113, С. 104612 - 104612

Опубликована: Дек. 13, 2024

Язык: Английский

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