Nonequilibrium landscape of amyloid-beta and calcium ions in application to Alzheimer's disease
Physical review. E,
Год журнала:
2025,
Номер
111(1)
Опубликована: Янв. 21, 2025
Amyloid-beta
(Aβ)
peptides
and
calcium
ions
(Ca2+)
serve
critical
roles
in
various
physiological
processes
inside
neurons,
but
their
dysregulation
is
involved
the
development
of
neurological
disorders,
including
Alzheimer's
disease.
Particularly,
Aβ42
alter
Ca2+
homeostasis,
resulting
synaptic
dysfunction
neuronal
damage.
On
other
hand,
can
affect
Aβ
aggregation
clearance
routes,
either
worsening
or
improving
AD
pathogenesis.
We
have
considered
a
deterministic
model
for
Aβ−Ca2+
interaction
studied
its
noise-induced
dynamics.
The
stochastic
sensitivity
analysis
helps
to
find
confidential
ellipses
stable
attractors
system.
In
addition,
we
developed
network
based
on
between
comprehend
dynamics
brain
connectome
better.
probabilistic
evolution
approach
characterizes
estimates
potentials
required
escape
from
one
attractor
another.
numerical
simulations
suggest
that
more
connected
node
requires
energy
switch
state,
noise
intensity
plays
crucial
role
such
cases.
Furthermore,
this
study
reveals
external
perturbations
uncover
novel
targets
drug
provide
insights
into
complex
interplay
protein
misfolding
disease
pathology.
locked
icon
Physics
Subject
Headings
(PhySH)Biological
neural
networksConnectomeDegree
distributionsDiseases,
physiology
&
pathologyNetwork
diffusionNeuronal
dynamicsProtein
dynamics,
structure
functionTherapeutics
Язык: Английский
A case of chronic lymphocytic leukaemia with initial symptoms of cognitive impairment
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 24, 2025
Abstract
Background:
Chronic
lymphocytic
leukaemia
(CLL)
is
a
type
of
that
often
ignored
in
the
initial
stages.
Slight
fever,
fatigue
and
night
sweats
are
common
presentations,
but
cognitive
decline
rare.
Case
presentation:
A
69-year-old
patient
with
early-stage
CLL
presented
rapid
decline.
The
was
taken
by
his
wife
to
seek
medical
attention
our
hospital.
In
reports
from
other
hospitals,
Mini-mental
State
Examination(MMSE)
score
10,
Montreal
Cognitive
Assessment(MoCA)
zero
since
he
could
not
cooperate.
MRI
revealed
bilateral
hippocampal
atrophy.
apolipoprotein
E
(APOE)
gene
test
genotype
e3/e4.
blood
also
high
leucocyte
lymphocyte
counts.
Peripheral
immunotyping
subsequently
performed,
results
abnormal
monoclonal
mature
B
cells.
final
diagnosis
CLL.
Discussion:
To
knowledge,
memory
loss
rare
primary
phase
However,
we
linked
this
patient’s
impairment
Язык: Английский
Protection of Green Tea Polyphenols against Neurodegenerative Diseases: Evidence and Possible Mechanisms
Journal of Nutrition,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
New Peripheral Pyridine‐Substituted Cobalt, Copper, and Manganese Phthalocyanines as Potential In Vitro Acetyl/Butyrylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(3)
Опубликована: Фев. 18, 2025
ABSTRACT
In
this
research,
we
designed
phthalocyanine
compounds
that
are
thought
to
be
used
as
potential
acetyl/butyrylcholinesterase
inhibitors
in
the
treatment
of
Alzheimer's
disease.
First,
phthalonitrile
compound
(
PNM‐CN
),
which
is
precursor
for
phthalocyanines,
was
synthesized.
Then,
by
cyclotetramerizing
compound,
pyridine‐substituted
peripheral
cobalt
PNM‐CoPc
copper
PNM‐CuPc
and
manganese
PNM‐MnClPc
)
were
synthesized,
their
structures
described
using
mass,
NMR
(except
phthalocyanines),
FT‐IR,
UV–Vis
phthalonitrile)
spectroscopic
techniques.
Investigations
carried
out
into
new
PNM‐Cu/Co/MnClPcs
phthalocyanines'
vitro
inhibitory
properties
against
butyrylcholinesterase
(BuChE)
acetylcholinesterase
(AChE).
With
an
IC
50
5.95
±
2.12
μM
(AChE)
0.74
0.01
(BuChE),
showed
most
potent
effect
AChE
BuChE
among
all
compounds.
Язык: Английский
A Novel Diagnostic Framework with an Optimized Ensemble of Vision Transformers and Convolutional Neural Networks for Enhanced Alzheimer’s Disease Detection in Medical Imaging
Joy Chakra Bortty,
Gouri Shankar Chakraborty,
Inshad Rahman Noman
и другие.
Diagnostics,
Год журнала:
2025,
Номер
15(6), С. 789 - 789
Опубликована: Март 20, 2025
Background/Objectives:
Alzheimer’s
disease
(AD)
is
a
progressive,
neurodegenerative
disorder,
which
causes
memory
loss
and
of
cognitive
functioning,
along
with
behavioral
changes.
Early
detection
important
to
delay
progression,
timely
intervention
increase
patients’
caregivers’
quality
life
(QoL).
One
the
major
primary
challenges
for
preventing
any
identify
at
initial
stage
through
quick
reliable
process.
Different
researchers
across
world
are
still
working
relentlessly,
coming
up
significant
solutions.
Artificial
intelligence-based
solutions
putting
great
importance
on
identifying
efficiently,
where
deep
learning
medical
imaging
highly
being
utilized
develop
frameworks.
In
this
work,
novel
optimized
framework
has
been
proposed
that
comes
remarkable
performance
can
classify
level
accurately
efficiently.
Methods:
A
powerful
vision
transformer
model
(ViT-B16)
three
efficient
Convolutional
Neural
Network
(CNN)
models
(VGG19,
ResNet152V2,
EfficientNetV2B3)
trained
benchmark
dataset,
‘OASIS’,
high
volume
brain
Magnetic
Resonance
Images
(MRI).
Results:
weighted
average
ensemble
technique
Grasshopper
optimization
algorithm
designed
ensure
maximum
accuracy
97.31%,
precision
97.32,
recall
97.35,
F1
score
0.97.
Conclusions:
The
work
compared
other
existing
state-of-the-art
techniques,
it
efficiency,
sensitivity,
reliability.
be
in
IoMT
infrastructure
one
access
smart
remote
diagnosis
services.
Язык: Английский
Moderate drinking benefits cognitive health in middle-aged and older Chinese: A latent class growth model analysis based on CHARLS
Journal of Affective Disorders,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Key genes and pathways in asparagine metabolism in Alzheimer’s Disease: a bioinformatics approach
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 28, 2025
Abstract
Background
Asparagine
(Asn)
metabolism
is
essential
for
maintaining
cellular
homeostasis
and
supporting
neuronal
energy
demands.
Recent
studies
have
suggested
its
dysregulation
may
contribute
to
Alzheimer’s
disease
(AD)
pathogenesis;
however,
the
specific
genes
regulatory
mechanisms
involved
remain
incompletely
understood.
Methods
Four
publicly
available
microarray
datasets
(GSE5281,
GSE29378,
GSE36980,
GSE138260)
were
utilized
investigate
with
differential
expression
between
control
AD
samples.
metabolism-related
(AMGs)
retrieved
from
GeneCards
database,
their
intersection
DEGs
yielded
candidate
asparagine
differentially
expressed
(AMG-DEGs).
Functional
enrichment
analysis
(Gene
Set
Enrichment
Analysis,
Gene
Ontology
Kyoto
Encyclopedia
of
Genes
Genomes),
protein–protein
interaction
(PPI)
network
analysis,
centrality
scoring
identified
hub
genes.
Regulatory
investigated
through
construction
competing
endogenous
RNA
transcription
factor
networks.
Potential
therapeutic
compounds
predicted
via
drug–gene
evaluated
using
molecular
docking
simulations.
Results
Thirty-nine
AMG-DEGs
found
be
enriched
in
neurodevelopmental,
synaptic
transmission,
inflammatory
signaling
pathways.
PPI
screening
revealed
seven
(
HPRT1
,
GAD2
TUBB3
GFAP
CD44
CCL2
NFKBIA
).
highlighted
miRNAs,
long
non-coding
RNAs,
factors
modulation.
Drug
Bathocuproine
disulfonate,
DL-Mevalonic
acid,
Phenethyl
isothiocyanate
as
promising
strong
binding
affinities
proteins.
Conclusion
This
study
comprehensively
maps
reveals
a
set
elements
potentially
progression.
The
provide
foundation
further
experimental
validation
development
novel
metabolism-targeted
strategies
treatment.
Язык: Английский
The Vicious Consequences of Chronic Kidney Disease on Cognitive Impairment and Alzheimer’s Disease
ACS Chemical Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
Chronic
kidney
disease
(CKD)
and
Alzheimer's
(AD)
are
two
prevalent
debilitating
conditions
that
frequently
coexist,
with
CKD
contributing
to
cognitive
decline
potentially
exacerbating
AD
pathology.
In
CKD,
irreversible
changes
in
the
structure
or
function
of
kidneys
observed,
while
is
primarily
marked
by
amyloid
deposition
tau
Both
involve
complex
multifactorial
pathophysiology
affecting
brain
functioning,
highlighting
need
for
comprehensive
research
understand
their
potential
crosstalk.
This
review
articulates
possible
molecular
mechanisms
underlying
both
diseases,
focusing
on
key
pathways,
including
oxidative
stress,
inflammation,
vascular
dysfunction,
hypertension,
uremic
toxin
accumulation.
These
interconnected
suggest
a
bidirectional
relationship
where
dysfunction
accelerates
vice
versa.
Additionally,
we
examine
critical
risk
factors
implicated
AD,
instance,
vitamin
D
deficiency,
erythropoietin
dysregulation,
endothelin
action,
klotho
gene
expression,
role
extracellular
vesicle,
which
may
influence
progression
through
effects
brain,
influencing
function.
Further,
emphasized
biomarkers
could
aid
diagnosing
monitoring
these
comorbid
conditions,
like
beta,
tau,
homocysteine,
cystatin
C,
creatinine,
proteinuria,
estimated
glomerular
filtration
rate.
Lastly,
highlights
treatment
strategies
managing
concurrently,
therapeutic
approaches
address
common
pathophysiological
mechanisms.
not
only
aim
causes
but
also
offer
slow
even
prevent
impairment.
Moreover,
recommend
further
refine
approaches,
execute
correlational
studies
progression,
design
clinical
trials
aiming
establish
effective,
tailored
treatments
this
dual
burden
disease.
Язык: Английский
Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Coumarin–Triazole–Isatin Hybrids as Selective Butyrylcholinesterase Inhibitors
Molecules,
Год журнала:
2025,
Номер
30(10), С. 2121 - 2121
Опубликована: Май 11, 2025
A
series
of
21
novel
coumarin–triazole–isatin
hybrids
was
synthesized
and
evaluated
for
their
potential
as
multitarget
agents
in
Alzheimer’s
disease
(AD).
The
compounds
featured
variations
alkyl
linker
length
that
connects
coumarin
triazole
substitution
at
the
5-position
isatin
ring.
Several
derivatives
showed
potent
butyrylcholinesterase
(BChE)
inhibition
with
selectivity
over
acetylcholinesterase
(AChE).
lead
compound,
6c1,
exhibited
strong
BChE
(IC50
=
1.74
μM),
surpassing
donepezil.
Enzyme
kinetics
revealed
a
mixed-type
mechanism,
while
molecular
docking
studies
confirmed
dual
binding
catalytic
peripheral
sites.
Structure–activity
relationship
(SAR)
analysis
highlighted
influence
flexibility
steric/electronic
effects
substituents.
observed
selectivity,
combined
favorable
vitro
profiles,
identifies
these
promising
leads
AD
drug
development.
Язык: Английский
Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer’s disease
Annals of Human Biology,
Год журнала:
2025,
Номер
52(1)
Опубликована: Июнь 4, 2025
Single
nucleotide
polymorphisms
(SNPs)
of
ghrelin
gene
are
associated
with
cognitive
function
while
is
Alzheimer's
disease
(AD).
To
determine
the
relationship
between
SNPs,
function,
and
activities
daily
living
(ADLs)
in
elderly
AD
patients.
This
study
included
100
patients
as
group,
72
healthy
control
group.
Pearson's
correlation
analysis
was
performed.
The
frequency
A
allele
at
rs55821288
significantly
higher
group
than
(p
<
0.05).
Similarly,
AA
genotype
MMSE,
QOL-AD,
ADLs
scores
were
lower
revealed
that
inversely
correlated
distribution
locus
had
a
negative
linear
Ghrelin
closely
among
Язык: Английский