Bio‐Nano Innovations Targeting the Neurovascular Complex for Epilepsy Treatment DOI
Xin Wang, Yikang Cheng, Zhenghan Qi

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Abstract Epilepsy is a prevalent chronic neurological disorder characterized by seizures resulting from an imbalance between excitatory and inhibitory neurons. While pharmacotherapy remains the standard treatment, traditional faces significant challenges, including poor brain penetration, high drug resistance rates, providing only symptomatic relief, rather than addressing underlying causes for comprehensive cure. Recently, neurovascular complex (NVC) has gained attention its critical role in development progression of epilepsy. Simultaneously, various innovative bio‐nanotechnology systems have emerged, specifically designed to enhance delivery across enable precise targeting within lesion. Herein, this review begins outlining core NVC involved epilepsy breaking it down into four key components: blood‐brain barrier (BBB), neurons, glial cells, microenvironment. The viability improve therapy analyzed. Next, systems, detailing their design principles, construction strategies, preclinical evaluations are highlighted. Finally, prospects next‐generation nanotechnologies challenges that must be overcome effective clinical translation discussed. Overall, aims guide more efficient bio‐nano therapies, ultimately enhancing treatment outcomes patients.

Язык: Английский

Bio‐Nano Innovations Targeting the Neurovascular Complex for Epilepsy Treatment DOI
Xin Wang, Yikang Cheng, Zhenghan Qi

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Abstract Epilepsy is a prevalent chronic neurological disorder characterized by seizures resulting from an imbalance between excitatory and inhibitory neurons. While pharmacotherapy remains the standard treatment, traditional faces significant challenges, including poor brain penetration, high drug resistance rates, providing only symptomatic relief, rather than addressing underlying causes for comprehensive cure. Recently, neurovascular complex (NVC) has gained attention its critical role in development progression of epilepsy. Simultaneously, various innovative bio‐nanotechnology systems have emerged, specifically designed to enhance delivery across enable precise targeting within lesion. Herein, this review begins outlining core NVC involved epilepsy breaking it down into four key components: blood‐brain barrier (BBB), neurons, glial cells, microenvironment. The viability improve therapy analyzed. Next, systems, detailing their design principles, construction strategies, preclinical evaluations are highlighted. Finally, prospects next‐generation nanotechnologies challenges that must be overcome effective clinical translation discussed. Overall, aims guide more efficient bio‐nano therapies, ultimately enhancing treatment outcomes patients.

Язык: Английский

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