Hawthorn leaf and its extract alleviate high-fat diet-induced obesity and modulate gut microbiome in mice DOI Creative Commons
Ziqi Liu, Tianwen Gao,

Haoyu Chang

и другие.

Current Research in Food Science, Год журнала: 2025, Номер 10, С. 101025 - 101025

Опубликована: Янв. 1, 2025

Obesity has emerged as a global health issue with its prevalence continuously increasing and being associated multiple comorbidities. Although existing medications are effective, they often come significant side effects, making dietary therapy an advantageous alternative. Hawthorn leaves their active component, vitexin, have shown potential in regulating lipid metabolism improving gut microbiota imbalance. This study utilized high-fat diet-induced obese mouse model, administering different doses of hawthorn vitexin for 13 weeks, employed 16S rRNA sequencing metabolomics to analyze the composition metabolites. The results demonstrated that significantly slowed body weight gain, improved glucose tolerance, regulated blood levels, downregulated expression obesity-related gene mice (ppar-α, ppar-γ, fas). Additionally, treatment groups showed improvement diversity. Both increased abundance Kineothrix, Paramuribaculum, Lawsonibacter (which belong Bacillota phylum) Olsenella (Actinobacteria phylum), while reducing Anaerotignum (Bacillota phylum). Moreover, treatments may alleviate symptoms by fecal content testosterone propionate, formoterol, isoleucyl-prolyl-proline, decreasing Trolox. These findings highlight functional foods obesity management modulating pathways, offering promising approach.

Язык: Английский

Hawthorn leaf and its extract alleviate high-fat diet-induced obesity and modulate gut microbiome in mice DOI Creative Commons
Ziqi Liu, Tianwen Gao,

Haoyu Chang

и другие.

Current Research in Food Science, Год журнала: 2025, Номер 10, С. 101025 - 101025

Опубликована: Янв. 1, 2025

Obesity has emerged as a global health issue with its prevalence continuously increasing and being associated multiple comorbidities. Although existing medications are effective, they often come significant side effects, making dietary therapy an advantageous alternative. Hawthorn leaves their active component, vitexin, have shown potential in regulating lipid metabolism improving gut microbiota imbalance. This study utilized high-fat diet-induced obese mouse model, administering different doses of hawthorn vitexin for 13 weeks, employed 16S rRNA sequencing metabolomics to analyze the composition metabolites. The results demonstrated that significantly slowed body weight gain, improved glucose tolerance, regulated blood levels, downregulated expression obesity-related gene mice (ppar-α, ppar-γ, fas). Additionally, treatment groups showed improvement diversity. Both increased abundance Kineothrix, Paramuribaculum, Lawsonibacter (which belong Bacillota phylum) Olsenella (Actinobacteria phylum), while reducing Anaerotignum (Bacillota phylum). Moreover, treatments may alleviate symptoms by fecal content testosterone propionate, formoterol, isoleucyl-prolyl-proline, decreasing Trolox. These findings highlight functional foods obesity management modulating pathways, offering promising approach.

Язык: Английский

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