Strategies for combating antibiotic resistance in bacterial biofilms

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 19, 2024

Biofilms, which are complexes of microorganisms that adhere to surfaces and secrete protective extracellular matrices, wield substantial influence across diverse domains such as medicine, industry, environmental science. Despite ongoing challenges posed by biofilms in clinical research this field remains dynamic indeterminate. This article provides a contemporary assessment their treatment, with focus on recent advances, chronicle the evolving landscape biofilm research.

Язык: Английский

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A Wearable Antifouling Electrochemical Sensor Integrated with an Antimicrobial Microneedle Array for Uric Acid Detection in Interstitial Fluid

Analytica Chimica Acta, Год журнала: 2025, Номер 1339, С. 343610 - 343610

Опубликована: Янв. 3, 2025

Язык: Английский

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Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance

Chemical Engineering Journal, Год журнала: 2024, Номер 481, С. 148674 - 148674

Опубликована: Янв. 11, 2024

Multi-resistant pathogens can cause several nosocomial infections that harm hospital interventions or undermine biological processes. In this scenario, the development of novel and efficient antimicrobial materials is essential to reducing pathogen spread. Though many approaches have been followed with aim, scalability, safety, efficiency concerns still hamper their clinical transfer. work, we overcome these limitations by co-polymerizing phenolic derivatives amino-terminal ligands. The resulting coatings are successfully applied woven non-woven-based used in healthcare: paper, cotton polypropylene. Moreover, demonstrate multi-pathway activity against six bacteria (E. coli, P. aeruginosa, S. aureus, methicillin-resistant E. faecalis, B. subtilis) two fungi (C. albicans C. auris), a fact attributed i) reactive oxygen species generation over time ii) protic amino groups exposed on surface. After 180 min, viable reduced more than 99.9 %, comparable decline after 24 h. As proof-of-concept, coated commercial band-aids tested skin ex vivo bacterial growth about 90 %. Considering results long-lasting, vitro biocompatibility, scalability eco-friendly technology, represent promising alternative be healthcare environments, avoiding spread, resistance.

Язык: Английский

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Construction of RGO@N-ZnO nanocomposite photocatalyst for disinfection of microbes and dye degradation under visible light irradiation

Journal of the Taiwan Institute of Chemical Engineers, Год журнала: 2024, Номер 161, С. 105510 - 105510

Опубликована: Апрель 18, 2024

Язык: Английский

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Quaternary Ammonization Treatment Enhances the Antifouling Activities of Capsaicin-Based Polybenzoxazine Coatings

Langmuir, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Marine biofouling is an important factor that affects the service life of marine equipment. In this work, phenol source capsaicin-mimicking N-(4-hydroxy-3-methoxy-benzyl) acrylamide, two amine sources, 3-aminopropyltriethoxysilane (APTES) and furfurylamine (FFA), together with paraformaldehyde were used to prepare benzoxazine coatings, P(HA) P(HF). By reaction iodomethane, quaternary ammonium group was introduced into N position oxazine ring. Quaternarily ammonified coatings P(HAI) P(HFI) show exciting antibacterial performance compared untreated coating. The coating exhibited 93.8%, 96.4%, 99.9%, 99.9% killing rates for Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, respectively. ammonization treatment also precipitated further enhanced anti-alga activity excellent real-sea antifouling performances. However, introduction ionic groups hindered thermal polymerization benzoxazine, leading more defects on surface, resulting in corrosion resistance poorer than HA HF as detected from electrochemical neutral salt spray experiments. current density P(HF) 2 orders greater coatings. Our results shed light developing new routes polymeric desired functions.

Язык: Английский

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Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance

ACS Infectious Diseases, Год журнала: 2023, Номер 9(6), С. 1206 - 1220

Опубликована: Май 10, 2023

During previous stages of research, high biocidal activity toward microorganism archival strains has been used as the main indicator in development new antiseptic formulations. Although this factor remains one most important characteristics biocide efficiency, scale antimicrobial resistance spread causes serious concern. Therefore, focus shifts formulations with a stable effect even case prolonged contact pathogens. Here, we introduce an original isocyanuric acid alkylation method use available alkyl dichlorides, which opened access to wide panel multi-QACs chains various lengths between nitrogen atoms triazine and pyridine cycles. We complex approach for resulting series 17 compounds, including their antibiofilm properties, bacterial tolerance development, multiresistant pathogenic strains. As result these efforts, compounds have shown higher levels antibacterial against ESKAPE pathogens than widely commercial QACs. Hit possessed clinical also demonstrated long-term without significant tolerance. The overall results indicated level broad application prospects based on

Язык: Английский

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Preparation strategy of hydrogel microsphere and its application in skin repair

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Июль 24, 2023

In recent years, hydrogel microsphere has attracted much attention due to its great potential in the field of skin repair. This paper reviewed progress preparation strategy and application this review, several methods were summarized detail. addition, related research microspheres for repair was reviewed, focused on bioactive microspheres, antibacterial hemostatic as delivery platforms (hydrogel a microcarrier drugs, factors, or cells) Finally, limitations future prospects development presented. It is hoped that review can provide valuable reference promote

Язык: Английский

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Quaternary ammonium salt coated air filter for bioaerosol removal from building indoor air

Building and Environment, Год журнала: 2024, Номер 250, С. 111158 - 111158

Опубликована: Янв. 1, 2024

Язык: Английский

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Calcium Peroxide‐Based Hydrogels Enable Biphasic Release of Hydrogen Peroxide for Infected Wound Healing

Advanced Science, Год журнала: 2024, Номер 11(40)

Опубликована: Сен. 3, 2024

Abstract Wound infection is a major factor affecting the speed and quality of wound healing. While hydrogen peroxide (H 2 O ) recognized for its antibacterial capacity facilitation healing, administration requires careful dosage differentiation. Inappropriately matched dosages can protract healing infected wounds. Herein, calcium peroxide‐based hydrogel (CPO‐Alg hydrogel) fabricated to enable biphasic tapered release H , ensuring robust initial antimicrobial activity followed by sustained promotion cellular proliferation The design allowed nanoparticles (CPO NPs) being in two spatial niches within gel framework. When applied infectious wounds, CPO NPs with weak constraints are promptly released out gel, penetrating into regions serve as agents that eliminate bacteria biofilms at high concentrations. Conversely, entrapped structurally integrated remain confined, thus gradually degrading allowing mild through hydrolysis moist environment contributes cell growth later stage. CPO‐Alg represents an innovative practical solution protection chronic offering promising prospects advancing

Язык: Английский

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Fluorine-silicon/N+ modified waterborne acrylic coatings with good anticorrosion and antibacterial performances

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 696, С. 134359 - 134359

Опубликована: Май 24, 2024

Язык: Английский

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