Unraveling the secrets: Evolution of resistance mediated by membrane proteins

Drug Resistance Updates, Год журнала: 2024, Номер 77, С. 101140 - 101140

Опубликована: Авг. 16, 2024

Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields such as medicine, agriculture, and environmental science. Understanding its complexity devising innovative strategies are crucial for treating diseases like cancer managing resistant pests in agriculture. This paper explores the dual nature of mechanisms across different organisms: On one hand, animals, bacteria, fungi, plants, insects exhibit convergent evolution, leading to development similar mechanisms. other influenced by diverse pressures structural differences among organisms, they also demonstrate divergent characteristics. prevalent insects, reflecting their shared survival evolved through evolution address challenges. However, variations ecological environments biological characteristics result differing responses resistance. Therefore, examining these not only enhances our understanding adaptive but provides theoretical support insights addressing drug advancing pharmaceutical development.

Язык: Английский

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Monoclonal Antibodies as a Therapeutic Strategy against Multidrug-Resistant Bacterial Infections in a Post-COVID-19 Era

Life, Год журнала: 2024, Номер 14(2), С. 246 - 246

Опубликована: Фев. 9, 2024

The development of severe multidrug-resistant bacterial infections has recently intensified because the COVID-19 pandemic. According to guidelines issued by World Health Organization (WHO), routine antibiotic administration is not recommended for patients with supposed or confirmed mild SARS-CoV-2 infection pneumonia, unless clinically suspected. However, recent studies have pointed out that proportion non-essential use in infected remains high. Therefore, silent pandemic resistance a pressing issue regardless present threats presented To prevent delay entry into postulated post-antibiotic era, long-term advocacy rational antibiotics, optimization control procedures, and new antibacterial agents vaccines should be underscored as vital practices toolbox. Recently, monoclonal antibodies gradually received attention following advancement biotechnology well enhanced drug discovery cancer research. Although decent progress been made laboratory-based research promising results obtained clinical trials some these products, challenges still exist their widespread applications. This article describes current advantages antibodies, associated trials, perceived future perspectives challenges. Further, we anticipate more therapeutic combat drug-resistant increase resilience novel agents/strategies.

Язык: Английский

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Environmental Antimicrobial Resistance: Implications for Food Safety and Public Health

Antibiotics, Год журнала: 2024, Номер 13(11), С. 1087 - 1087

Опубликована: Ноя. 14, 2024

Antimicrobial resistance (AMR) is a serious global health issue, aggravated by antibiotic overuse and misuse in human medicine, animal care, agriculture. This study looks at the different mechanisms that drive AMR, such as environmental contamination, horizontal gene transfer, selective pressure, well severe implications of AMR for health. demonstrates need concerted efforts across scientific, healthcare, agricultural, policy sectors to control emergence AMR. Some crucial strategies discussed include developing antimicrobial stewardship (AMS) programs, encouraging targeted narrow-spectrum use, emphasizing significance strict regulatory frameworks surveillance systems, like Global Resistance Use Surveillance System (GLASS) Access, Watch, Reserve (AWaRe) classification. also emphasizes national international action plans combating promotes One Health strategy, which unifies environmental, animal, concludes preventing spread maintaining effectiveness antibiotics future generations requires comprehensive, multidisciplinary, internationally coordinated strategy.

Язык: Английский

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An Overview of the Genetic Mechanisms of Colistin-Resistance in Bacterial Pathogens: An Indian Perspective

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Colistin resistance in bacteria is a growing global issue, given its role as critical last-resort antibiotic, particularly for treating Gram-negative bacterial infections. Pathogens adopt multiple mechanisms, mediated either by plasmids or chromosomal changes. Some of the most frequently observed strategies include occurrence plasmid-borne mobile colistin (mcr) genes, enhanced efflux pump activity, mutations regulatory systems, and alterations lipid A structure. This article provides an overview studies investigating genetic mechanisms underlying nosocomial from India. total 37 were identified through online searches across various databases, including PubMed, ScienceDirect, Web Science. These reviewed to examine species their resistance. Over 26 (70.27%) focused on Klebsiella pneumoniae. The commonly reported mechanism involved two-component systems pmrAB phoPQ. Plasmid-mediated colistin-resistant mcr genes 22 (18.18%). Four overexpression comprehensive summary these studies, emphasizing presence diverse pathogens. It underscores necessity future genomic research broader range pathogens investigate prevalence different regions

Язык: Английский

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Non-steroidal anti-inflammatory drugs (NSAIDs) regimens enhance synergistic selective anticancer efficacy of chemotherapeutic agents on cultured cells

Journal of Dental Sciences, Год журнала: 2025, Номер 20(2), С. 1175 - 1195

Опубликована: Фев. 18, 2025

Cancer incidences are rising, presenting challenges due to severe side effects and resistance of chemotherapeutic agents. To address these issues, we propose a strategy involving pharmaceutical compositions PTM (Phytopolyphenols, Targeting drugs, Metals) regimens. This study aimed investigate NSAIDs (Non-steroidal anti-inflammatory drugs)-PTM regimens enhancing anticancer selectivity efficacy agents on cultured cancer cells. Effects drugs proliferation cells pathogens was assessed using MTT assay optical density at 600 nm (OD600) respectively. Synergistic drug combinations were determined combination index index. ATPase activity assayed colorimetric method. NSAIDs-PTM demonstrated selective synergistic effects. They also enhanced Cisplatin, 5-Fluorouracil, Methotrexate. The most effective increased by 16, 4, 23 fold against oral, lung, colon cell lines, Additionally, Methotrexate 8-21 the three Furthermore, all exhibited anti-efflux pump antibacterial four pathogens. findings indicate that not only possess properties but enhance Notably, ATPase, which may help overcome multidrug in treatment. Given components clinically safe, further clinical studies warranted.

Язык: Английский

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[Clinical and drug sensitivity characteristics of invasive non-typhoidal

PubMed, Год журнала: 2025, Номер 27(3), С. 315 - 320

Опубликована: Март 15, 2025

To investigate the clinical characteristics and drug resistance profile of invasive non-typhoidal Salmonella (NTS) enteritis in children Chengdu, China, providing a reference for rational use empirical treatment practice. A retrospective analysis was conducted on data 130 with bacterial due to NTS identified by fecal culture results sensitivity tests Chengdu from January 2022 December 2023. infections were mainly observed April September (113 cases, 86.9%), peak August (36 27.7%). Children aged <36 months accounted 86.2% (112/130) all main symptoms diarrhea (130 100%), fever (123 94.6%), hematochezia (112 86.2%). The isolates exhibited rate 64.6% ceftriaxone 63.8% cefotaxime, >90.0% piperacillin-tazobactam nitrofurantoin (nitrofurans). detection multidrug-resistant strains 48.5% (63/130), efficacy third-generation cephalosporins used 38 patients (29.2%) inconsistent tests. 0-6 years occurs area, relatively high incidence months. situation is severe NTS, may be an effective option treating children, while nitrofuran antibiotics might treat such infections.

Язык: Английский

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A novel member of drug/metabolite transporter (DMT) family efflux pump, SA00565, contributes to tetracycline antibiotics resistance in Staphylococcus aureus USA300

Microbiology Spectrum, Год журнала: 2024, Номер 12(6)

Опубликована: Апрель 23, 2024

Drug efflux systems have recently been recognized as a significant mechanism responsible for multidrug resistance in bacteria. In this study, we described the identification and characterization of new chromosomally encoded pump (SA00565)

Язык: Английский

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Exposure to imipenem at sub-minimum inhibitory concentration leads to altered expression of major outer membrane proteins in Acinetobacter baumannii

Journal of Applied Microbiology, Год журнала: 2024, Номер 135(5)

Опубликована: Апрель 22, 2024

Acinetobacter baumannii is a nosocomial pathogen known to be multidrug-resistant (MDR), especially drugs of the carbapenem class. Several factors contribute resistance, including efflux pumps, β-lactamases, alteration target sites, and permeability defects. In addition, outer membrane proteins (OMPs), like porins are involved in passage antibiotics, their could lead resistance development. This study aimed explore possible involvement OMPs developing due differential expression.

Язык: Английский

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Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening

ACS Medicinal Chemistry Letters, Год журнала: 2024, Номер 15(8), С. 1287 - 1297

Опубликована: Июль 15, 2024

Multidrug-resistant bacterial infections pose an ever-evolving threat to public health. Since the outset of antibacterial age, bacteria have developed a multitude diverse resistance mechanisms that suppress effectiveness current therapies. New drug entities, such as Novel Bacterial Topoisomerase Inhibitors (NBTIs), can circumvent this major issue. A computational docking model was employed predict binding DNA gyrase atypical NBTIs with novel pharmacophores. Synthesis based on and subsequent evaluation against both Gram-positive Gram-negative yielded congeners outstanding anti-staphylococcal activity varying select pathogens.

Язык: Английский

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Revolutionizing Infection Control: Harnessing the Power of Stem Cells for Precision Antimicrobial Therapy

Опубликована: Янв. 1, 2024

Язык: Английский

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