Cortical
laminar
bone
membrane
(CLBM)
is
well
known
for
its
extraordinary
mechanical
properties,
biocompatibility,
and
osteoconductive
potential,
thus,
it
has
been
revealed
as
a
revolutionary
biomaterial
in
periodontal
alveolar
regeneration.
CLBM
offers
superior
alternative
to
traditional
barrier
membranes
used
guided
regeneration
(GBR)
tissue
(GTR).
represents
significant
advancement
managing
complex
defects
by
overcoming
common
limitations
such
premature
degradation
inadequate
soft
support.
The
review
combines
insights
from
current
research
evaluate
the
biological
mechanisms,
clinical
applications
of
CLBM,
alongside
comparative
advantages
limitations.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
With
the
global
population
aging,
awareness
of
oral
health
is
rising.
Periodontitis,
a
widespread
bacterial
infectious
disease,
gaining
attention.
Current
novel
biomaterials
address
key
clinical
issues
like
infection,
gum
inflammation,
tooth
loosening,
and
loss,
focusing
on
antibacterial,
anti-inflammatory,
tissue
regeneration
properties.
However,
strategies
that
integrate
advantages
these
to
achieve
synergistic
therapeutic
effects
by
clearing
biofilms,
inhibiting
inflammation
activation,
restoring
periodontal
soft
hard
functions
remain
very
limited.
Recent
studies
highlight
link
between
periodontitis
systemic
diseases,
underscoring
complexity
disease.
There
an
urgent
need
find
comprehensive
treatment
plans
requirements.
Whether
integrating
new
enhance
existing
treatments
or
developing
approaches
replace
traditional
therapies,
efforts
will
drive
advancements
in
treatment.
Therefore,
this
review
compares
with
treatments.
It
highlights
design
concepts
mechanisms
functional
materials,
their
properties,
discusses
importance
strategies.
This
aims
provide
guidance
for
emerging
research
promote
development
precise
efficient
Theranostics,
Год журнала:
2025,
Номер
15(5), С. 1760 - 1786
Опубликована: Янв. 2, 2025
Smart
biomaterials
with
active
environmental
responsiveness
have
attracted
widespread
attention
in
recent
years.
Previous
studies
on
bioactive
glass
(BG)
mainly
focused
the
property
of
bioactivity,
while
little
has
been
paid
to
smart
response
BG.
Herein,
we
propose
concept
Bioactive
Glass
Composites
(SBGC)
which
are
capable
actively
responding
endogenous
disease
microenvironment
or
exogenous
physical
stimuli,
thereby
enabling
treatment
tissue
defect
sites
and
ultimately
promoting
regeneration.
In
this
review,
characteristics
SBGC
different
internal
external
environments
described.
Subsequently,
applications
complex
repair
tumors,
infections,
diabetes
reviewed.
By
deeply
analyzing
progress
fields,
review
will
point
out
direction
for
research
next-generation
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 15, 2025
The
impaired
healing
of
alveolar
bone
defects
in
diabetic
patients
has
attracted
considerable
attention,
with
Mogroside
V
(MV)
emerging
as
a
promising
candidate
due
to
its
demonstrated
antioxidation,
hypoglycemic,
and
anti-inflammatory
properties
diabetes
mellitus.
To
address
the
limitations
oral
MV
administration,
such
low
bioavailability,
rapid
metabolism,
short
half-life,
we
developed
nanofiber
membrane
utilizing
electrospinning
technology
for
topical
application
by
preparing
membranes
using
MV,
chitosan
(CS),
nanohydroxyapatite
(HA),
poly(vinyl
alcohol)
(PVA)
raw
materials
prolong
effect
enhance
regeneration
patients.
MV/HA/PVA/CS
exhibited
good
fiber
diameter,
prolonged
drug
release,
suitable
degradation
time,
along
other
favorable
properties.
In
vitro
experiments
revealed
excellent
biocompatibility,
effectiveness
promoting
osteogenesis,
upregulation
osteogenic
genes,
concurrent
downregulation
pro-inflammatory
genes.
vivo
evaluations
further
confirmed
ability
effectively
modulate
microenvironment,
reduce
damage,
facilitate
effects
diabetics.
These
findings
suggest
that
sustained
release
may
serve
biomaterial,
providing
new
insights
into
improving
defects.
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Март 5, 2025
Periodontitis
is
a
chronic
inflammatory
disease
induced
by
the
microbiome,
leading
to
destruction
of
periodontal
structures
and
potentially
resulting
in
tooth
loss.
Using
local
drug
delivery
systems
as
an
adjunctive
therapy
scaling
root
planning
periodontitis
promising
strategy.
However,
this
administration
method's
effectiveness
constrained
complexity
environment.
Nanomaterials
have
demonstrated
significant
potential
antibacterial
treatment
periodontitis,
attributed
their
controllable
size,
shape,
surface
charge,
high
design
flexibility,
reactivity,
specific
area.
In
review,
we
summarize
complex
microenvironment
difficulties
explicitly
reviewing
application
strategies
nanomaterials
with
unique
properties
distinct
periodontitis.
Furthermore,
review
discusses
limitations
current
research,
proposes
feasible
solutions,
explores
prospects
for
using
context.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Barrier
membranes
are
essential
components
of
tissue
regenerative
therapies,
acting
as
physical
barriers
to
protect
the
healing
site.
Although
collagen-based
widely
used,
they
degrade
enzymatically,
often
triggering
inflammation
and
cytotoxicity
arising
from
residual
cross-linking
agents.
Synthetic
polymer-based
membranes,
such
polydioxanone
(PDO),
present
customizable
properties,
predictable
degradation
rates,
induce
bone
formation
more
effectively.
However,
both
materials
at
risk
exposure
microbial
contamination.
To
address
this,
antibiotics
have
been
loaded
onto
drug-delivery
systems,
a
strategy
that
has
not
yet
explored
for
PDO
membranes.
In
this
study,
oral
polymicrobial
contamination
PDO-based
was
evaluated
compared
with
collagen
aimed
develop
an
amoxicillin-loaded
(AMX-PDO)
membrane.
For
purpose,
different
pore
sizes
(0.25,
0.50,
1.00
mm)
two
commercially
available
were
evaluated,
using
in
vitro
situ
models,
terms
accumulation.
Next,
AMX-PDO
developed
by
glow
discharge
plasma
Ar
O2
gases
amoxicillin
compound.
The
findings
revealed
similar
levels
but
modulated
composition
reduced
(∼3-5
fold-decrease)
specific
pathogens.
membrane
maintained
chemical
properties
those
untreated
it
significantly
accumulation
prevented
cells
passing
through
them.
Thus,
acted
than
passive
only,
rather
biologically
active
barriers.
Therefore,
loading
on
barrier
means
technology
seems
be
promising
prevent
local
infection
during
therapy.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
Periodontitis-induced
periodontal
bone
defects
significantly
impact
patients’
daily
lives.
The
guided
tissue
regeneration
and
techniques,
which
are
based
on
barrier
membranes,
have
brought
hope
for
the
of
defects.
However,
traditional
membranes
lack
antimicrobial
properties
cannot
effectively
regulate
complex
oxidative
stress
microenvironment
in
defect
areas,
leading
to
unsatisfactory
outcomes
promoting
regeneration.
To
address
these
issues,
our
study
selected
collagen
membrane
as
substrate
material
synthesized
a
novel
(PO/4-BPBA/Mino@COL,
PBMC)
with
an
intelligent
coating
through
simple
layer-by-layer
assembly
method,
incorporating
reactive
oxygen
species
(ROS)-scavenging
components,
commercial
dual-functional
linkers
building
blocks.
Experimental
results
indicated
that
PBMC
exhibited
good
degradability,
hydrophilicity
ROS-responsiveness,
allowing
slow
controlled
release
drugs.
outstanding
antibacterial,
antioxidant
biocompatibility
contributed
resistance
pathogen
infection
regulation
balance,
while
enhancing
migration
osteogenic
differentiation
human
ligament
stem
cells.
Finally,
using
rat
model,
therapeutic
effect
under
conditions
was
confirmed.
In
summary,
designed
this
significant
potential
clinical
application
provide
reference
design
future
regenerative
functional
materials.
