Resolving host-guest interactions between pillararenes and homoserine lactones to restrain bacterial quorum sensing DOI Creative Commons

Otso I.V. Luotonen,

Ekaterina Osmekhina, Eduardo Anaya‐Plaza

и другие.

Cell Reports Physical Science, Год журнала: 2024, Номер 5(7), С. 102089 - 102089

Опубликована: Июль 1, 2024

Using supramolecular host molecules to hinder bacterial quorum sensing (QS) is a potential approach in circumventing antimicrobial resistance (AMR). The emergent family of pillararenes offers promising candidates for binding homoserine lactones (HSLs), signaling used by gram-negative species, including WHO critical-priority antibiotic-resistant bacteria. Here, we compare seven cationic against four HSLs, from (supra)molecular interactions biological assays. Complexation, characterized dye displacement assay and NMR spectroscopy, complemented all-atom molecular dynamics (MD) simulations, was compared effects systems, studied using HSL reporter system as well biofilm pyocyanin assays models QS-mediated virulence. improves approximately 10-fold versus previous reports with hydroxyl-functionalized pillararene, deeper-cavity marked preference the longest-tailed identified. Successful capture directly reflected impaired formation production improved healing open wound vivo models.

Язык: Английский

Supramolecular Self‐Assembly of Monosubstituted Pillar[5]Arenes Under the Control of the Nature of the Amide Moiety DOI
D. N. Shurpik, Yulia I. Aleksandrova, Lyaysan I. Makhmutova

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(4)

Опубликована: Янв. 1, 2025

Abstract In this study, we have shown for the first time that introduction of a single alkylamide substituent into macrocyclic platform pillar[5]arene opens up possibility to control supramolecular properties platform. The ability synthesized pillar[5]arenes form pseudorotaxane associates both in solutions and crystalline state was studied by complex physical methods. Linear secondary amide fragments such as N , ‐diethylethane‐1,2‐diamide, ‐dimethylpropane‐1,3‐diamide, or ‐aminoethylmorpholide structure promote formation self‐inclusion complexes solution states. Whereas tertiary amides pyrrolidide morpholide moieties favor polymers obtained results show prospects use structures pillar[ n ]arenes customization units controlling self‐assembly.

Язык: Английский

Процитировано

0
Research Progress on Photoresponsive Host-Guest Supramolecular Systems Based on Pillararenes DOI

傲冉 刘

Advances in Analytical Chemistry, Год журнала: 2025, Номер 15(01), С. 22 - 33

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Resolving host-guest interactions between pillararenes and homoserine lactones to restrain bacterial quorum sensing DOI Creative Commons

Otso I.V. Luotonen,

Ekaterina Osmekhina, Eduardo Anaya‐Plaza

и другие.

Cell Reports Physical Science, Год журнала: 2024, Номер 5(7), С. 102089 - 102089

Опубликована: Июль 1, 2024

Using supramolecular host molecules to hinder bacterial quorum sensing (QS) is a potential approach in circumventing antimicrobial resistance (AMR). The emergent family of pillararenes offers promising candidates for binding homoserine lactones (HSLs), signaling used by gram-negative species, including WHO critical-priority antibiotic-resistant bacteria. Here, we compare seven cationic against four HSLs, from (supra)molecular interactions biological assays. Complexation, characterized dye displacement assay and NMR spectroscopy, complemented all-atom molecular dynamics (MD) simulations, was compared effects systems, studied using HSL reporter system as well biofilm pyocyanin assays models QS-mediated virulence. improves approximately 10-fold versus previous reports with hydroxyl-functionalized pillararene, deeper-cavity marked preference the longest-tailed identified. Successful capture directly reflected impaired formation production improved healing open wound vivo models.

Язык: Английский

Процитировано

2