Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Cationic antimicrobial agents are widely recognized for combating microbial infections through their membrane-disruptive properties. Recently, sulfur dioxide (SO2) gas therapy has emerged as a promising alternative treating diseases, including bacterial infections. However, current systems often target only specific strains. Herein, we present amphiphilic alternating copolymers, DAPx (x = 1, 2, 3), incorporating cationic residues and thiol-responsive SO2-releasing moieties. In aqueous environments, copolymers self-assemble into micellar nanoassemblies (DAPxNp), exposing hydrophilic outward encapsulating hydrophobic moieties within the core to enable controlled sustained release of SO2 in presence glutathione (GSH). vitro studies reveal excellent biocompatibility DAP2 Np with broad-spectrum antibacterial activity against both Gram-positive (Bacillus subtilis, Staphylococcus aureus) Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. Mechanistic investigations confirm eradication via membrane disruption reactive oxygen species generation. This study underscores remarkable efficacy polymers resisting

Язык: Английский