International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 9100 - 9100
Опубликована: Авг. 22, 2024
The
impressive
adhesive
capacity
of
marine
mussels
has
inspired
various
fascinating
designs
in
biomedical
fields.
Mussel-inspired
injectable
hydrogels,
as
a
type
promising
mussel-inspired
material,
have
attracted
much
attention
due
to
their
minimally
invasive
property
and
desirable
functions
provided
by
components.
In
recent
decades,
hydrogels
been
designed
widely
applied
numerous
rational
incorporation
catechol
groups
endows
the
with
potential
exhibit
many
properties,
including
tissue
adhesiveness
self-healing,
antimicrobial,
antioxidant
capabilities,
broadening
applications
this
review,
we
first
give
brief
introduction
adhesion
mechanism
characteristics
hydrogels.
Further,
typical
design
strategies
are
summarized.
methodologies
for
integrating
into
polymers
crosslinking
methods
discussed
section.
addition,
systematically
overview
applications,
focus
on
how
unique
properties
these
benefit
challenges
perspectives
last
This
review
may
provide
new
inspiration
novel
bioinspired
facilitate
application
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
High
levels
of
reactive
oxygen
species
(ROS)
and
hypoxia
in
diabetic
wounds
significantly
hinder
the
healing
process.
In
this
work,
a
kind
catalase-like
nanozyme-hybrid
hydrogel
was
developed
to
explore
potential
harnessing
endogenous
excessive
ROS
as
an
source
synergistically
regulate
oxidative
stress
hypoxia,
thereby
enhancing
wound
healing.
The
hydrogels
exhibited
rapid
degradation
controlled
release
ferrihydrite
nanozymes
response
stress,
which
continuously
catalyzed
decomposition
H2O2
generate
oxygen,
effectively
scavenging
reducing
risk
local
toxicity.
relieved
intracellular
hypoxic
microenvironment
simultaneously
vitro.
dressings
inhibited
damage
at
sites,
promoted
epidermis
formation
collagen
deposition,
accelerated
db/db
mice.
Therefore,
represent
promising
strategy
for
dressings,
addressing
both
improve
outcomes.
ACS Materials Letters,
Год журнала:
2025,
Номер
unknown, С. 489 - 499
Опубликована: Янв. 6, 2025
Severe
burn
wounds
accompanied
by
infections
associated
with
multidrug-resistant
(MDR)
bacteria
are
increasingly
prevalent.
However,
and
inflammatory
storms
occurring
in
the
early
stages
of
healing
frequently
lack
effective
interventions,
which
then
disrupt
subsequent
normal
events,
ultimately
resulting
suboptimal
outcomes.
Unfortunately,
currently
multifunctional
hydrogel
dressings
mostly
focused
on
a
single
stage
process
(inflammatory
or
proliferative
phase),
failing
to
optimally
orchestrate
immune
microenvironment
tissue
regeneration,
limits
their
clinical
applicability.
In
response,
we
customized
GelMA-based
repair
system
involved
whole
promote
regeneration
fine-tuned
milieu.
The
combination
formulas
demonstrated
efficacy
alleviating
hyperinflammatory
infiltration
stimulating
neovascularization,
hair
follicle
collagen
deposition
during
stage.
Our
dual-response
presented
an
innovative
strategy
for
refractory
wound
management,
matching
exigencies.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(34), С. 44467 - 44484
Опубликована: Авг. 14, 2024
Multiphase
Pickering
emulsions,
including
two
or
more
active
agents,
are
of
great
importance
to
effectively
manage
complicated
wounds.
However,
current
strategies
based
on
emulsions
still
unsatisfying
since
they
involve
only
stabilization
by
inactive
particles
and
encapsulation
the
hydrophobic
drugs
in
oil
phase.
Herein,
thyme
essential
(TEO)
was
encapsulated
shell
functional
tea
polyphenol
(TP)-curcumin
(Cur)
nanoparticles
(TC
NPs)
exemplarily
develop
a
novel
emulsion
(TEO/TC
PE).
Hydrophobic
Cur
loaded
with
hydrophilic
TP
obtain
TC
NPs,
under
homogenization,
these
NPs
adsorbed
surface
TEO
droplets
form
stable
core-shell
structure.
Owing
such
an
oil-in-water
(O/W)
structure,
sequential
release
first
from
pH-responsive
disintegrated
then
leaked
yielded
synergetic
functions
TEO/TC
PE,
leading
enhanced
antibacterial,
biofilm
elimination,
antioxidant,
anti-inflammatory
activities.
This
injectable
PE
applied
treat
infected
full-thickness
skin
defects,
satisfactory
wound
healing
effects
were
achieved
rapid
angiogenesis,
collagen
deposition,
regeneration.
The
present
constituted
entirely
plant-sourced
products
is
biosafe
expected
spearhead
future
development
dressings.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Дек. 25, 2024
Diabetic
wounds,
particularly
diabetic
foot
ulcers
(DFUs),
are
significant
threats
to
human
well-being
due
their
impaired
healing
from
poor
circulation
and
high
blood
sugar,
increased
risk
of
infection
potential
for
severe
complications
like
amputation,
all
compounded
by
peripheral
neuropathy
chronic
inflammation.
Most
therapies
dressings
DFUs
focus
on
one
symptom
at
a
time,
however,
multifunctional
smart
self-healing
hydrogels
can
withstand
multifactorial
motional
wounds.
Motional
wounds
easy-to-split
that
experience
tension,
compression,
movement
caused
stress
now
then.
Hyaluronic
acid
(HA)
based
stand
out
among
other
biomaterials
ability
cover
irregular
wound
surfaces,
maintain
moist
environment,
repair
themselves
when
ruptured,
exhibit
excellent
biocompatibility.
These
damages
recover
the
functional
properties
during
healing.
also
act
as
therapeutic
delivery
vehicles
tissue
regeneration
systems.
This
review
demonstrates
HA-based
Due
its
capabilities,
these
offer
customized
approach
The
critically
examines
challenges
future
directions
in
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2025,
Номер
165, С. 106927 - 106927
