International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 9100 - 9100
Опубликована: Авг. 22, 2024
The
impressive
adhesive
capacity
of
marine
mussels
has
inspired
various
fascinating
designs
in
biomedical
fields.
Mussel-inspired
injectable
hydrogels,
as
a
type
promising
mussel-inspired
material,
have
attracted
much
attention
due
to
their
minimally
invasive
property
and
desirable
functions
provided
by
components.
In
recent
decades,
hydrogels
been
designed
widely
applied
numerous
rational
incorporation
catechol
groups
endows
the
with
potential
exhibit
many
properties,
including
tissue
adhesiveness
self-healing,
antimicrobial,
antioxidant
capabilities,
broadening
applications
this
review,
we
first
give
brief
introduction
adhesion
mechanism
characteristics
hydrogels.
Further,
typical
design
strategies
are
summarized.
methodologies
for
integrating
into
polymers
crosslinking
methods
discussed
section.
addition,
systematically
overview
applications,
focus
on
how
unique
properties
these
benefit
challenges
perspectives
last
This
review
may
provide
new
inspiration
novel
bioinspired
facilitate
application
With
the
advent
of
smart
era,
demand
for
clean
energy
is
rising,
and
flexible
triboelectric
nanogenerators
(F-TENGs)
based
on
elastomers
have
garnered
significant
attention.
Based
principles
electrostatic
induction
coupling,
F-TENGs
can
convert
mechanical
motion
into
electrical
are
widely
utilized
in
wearable
devices
blue
energy.
offer
a
simple
design,
ease
manufacturing,
usage
scenarios.
However,
several
weaknesses
still
limit
their
development.
For
example,
F-TENG
materials
cannot
recover
from
fatigue
damage
prone
to
output
performance
degradation
under
frequent
friction
or
complex
external
conditions,
leading
failure.
To
address
these
issues,
researchers
explored
use
self-healable
polymer-based
layers
electrodes.
This
review
will
provide
detailed
summary
key
scientific
technological
challenges
faced
by
harsh
environments,
including
ambient,
high
low
temperatures,
humidity,
strong
acids
bases.
Furthermore,
research
progress
addressing
issues
future
development
also
be
presented
explored.
paper
aims
valuable
insights
guidance
in-depth
broad
applications
TENGs.
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101711 - 101711
Опубликована: Март 27, 2025
Developing
and
utilizing
effective
local
antimicrobial
agents
can
help
treat
periodontitis
while
minimizing
the
risks
associated
with
systemic
antibiotic
use.
Recent
studies
have
shown
that
mucosal
adhesion
properties
of
hydrogels
play
a
potential
role
in
treatment
periodontitis.
The
hydrogel
improve
contact
retention
time
drugs
periodontal
pocket.
Through
mucosa,
it
interacts
mucin
coating
surface
epithelium
teeth
to
form
specific
interface
force.
exhibits
strong
(adhesion
strength:
5-6
N/cm2)
prolonged
pockets
(≥6
h),
enabling
sustained
drug
release
through
dynamic
sol-gel
transitions
triggered
by
pH
reactive
oxygen
species
(ROS).
This
design
overcomes
limitations
poor
mechanical
stability
conventional
formulations.
balance
oral
microbiota
plays
an
important
maintaining
health.
Probiotics,
colonizing
cavity,
transform
infected
site
from
environment
rich
inflammatory
cytokines
more
benign
environment,
inhibit
harmful
pathogenic
microorganisms,
contribute
overall
Microenvironment
sensitive
perform
sol
gel
transformation
situ,
accurately
control
when
exposed
various
stimuli
(such
as
temperature
change,
light,
species,
etc.).
Oral
probiotics
anti-inflammatory
are
encapsulated
proliferation
pathogens
planting
mouth
producing
metabolites,
effectively
preventing
treating
diseases.
ACS Macro Letters,
Год журнала:
2024,
Номер
13(5), С. 475 - 482
Опубликована: Апрель 9, 2024
The
development
of
antioxidant
wound
dressings
to
remove
excessive
free
radicals
around
wounds
is
essential
for
healing.
In
this
study,
we
developed
an
efficient
strategy
prepare
self-healing
hydrogels
as
by
combining
multicomponent
reactions
(MCRs)
and
postpolymerization
modification.
A
polymer
containing
ferrocene
phenylboronic
acid
groups
was
via
the
Biginelli
reaction,
followed
This
due
its
moieties
can
rapidly
cross-link
poly(vinyl
alcohol)
realize
hydrogel
through
dynamic
borate
ester
linkages.
has
low
cytotoxicity
biocompatible.
in
vivo
experiments,
superior
existing
clinical
promoting
study
demonstrates
value
reaction
exploring
biomaterials,
potentially
offering
insights
into
design
other
multifunctional
polymers
related
materials
using
different
MCRs.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(9), С. 4360 - 4370
Опубликована: Авг. 21, 2024
Diabetic
foot
ulcers
are
a
severe
complication
of
diabetes,
imposing
substantial
burden
on
both
health
and
the
economy.
Bacterial
infections,
high
glucose
levels,
intricate
microenvironment
oxidation
collectively
hinder
healing
diabetic
wounds.
Hydrogels
responsive
to
have
demonstrated
significant
advantages
in
treating
wounds
due
their
ability
release
drugs
demand.
The
study
utilized
modified
pectin
hyaluronic
acid
develop
self-recognizing
self-treating
composite
hydrogel.
Within
this
hydrogel,
insulin
was
encapsulated
using
metal–organic
framework
with
an
ROS-responsive
coating
(ZIF-8@PEG-TK).
Under
low
pH
conditions,
INS@ZIF-8@PEG-TK
released
responded
excess
ROS,
ensuring
sustained
release.
This
hydrogel
exhibited
excellent
antimicrobial
antioxidant
activities
along
biocompatibility.
It
promoted
polarization
macrophages,
reduced
accelerated
cell
proliferation
collagen
deposition,
leading
rapid
wound
closure.
Accordingly,
microenvironment-responsive
is
promising
biomaterial
for
chronic
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 9100 - 9100
Опубликована: Авг. 22, 2024
The
impressive
adhesive
capacity
of
marine
mussels
has
inspired
various
fascinating
designs
in
biomedical
fields.
Mussel-inspired
injectable
hydrogels,
as
a
type
promising
mussel-inspired
material,
have
attracted
much
attention
due
to
their
minimally
invasive
property
and
desirable
functions
provided
by
components.
In
recent
decades,
hydrogels
been
designed
widely
applied
numerous
rational
incorporation
catechol
groups
endows
the
with
potential
exhibit
many
properties,
including
tissue
adhesiveness
self-healing,
antimicrobial,
antioxidant
capabilities,
broadening
applications
this
review,
we
first
give
brief
introduction
adhesion
mechanism
characteristics
hydrogels.
Further,
typical
design
strategies
are
summarized.
methodologies
for
integrating
into
polymers
crosslinking
methods
discussed
section.
addition,
systematically
overview
applications,
focus
on
how
unique
properties
these
benefit
challenges
perspectives
last
This
review
may
provide
new
inspiration
novel
bioinspired
facilitate
application
