MXene-reinforced bioactive polymer hydrogels for biomedical applications
APL Materials,
Год журнала:
2024,
Номер
12(8)
Опубликована: Авг. 1, 2024
MXenes,
a
novel
class
of
two-dimensional
(2D)
materials,
have
attracted
considerable
attention
in
various
fields,
especially
drug
delivery,
wound
healing,
bone
tissue
engineering,
biosensing,
and
cancer
treatment.
Thanks
to
their
remarkable
physicochemical
properties,
MXenes
hold
great
promise
for
biomedical
applications.
Concurrently,
hydrogels
composed
polymers
been
extensively
utilized
contexts.
The
unique
properties
facilitate
integration
into
bioactive
with
enhanced
functions
thereby
endowing
the
composites
multifunctional
capabilities.
MXene-reinforced
polymer
(MRPHs)
synergistically
combine
advantageous
characteristics
both
hydrogels,
making
them
highly
adaptable
other
theranostic
strategies
medical
In
this
comprehensive
review,
we
demonstrate
recent
advances
design
synthesis
MRPHs
Specifically,
introduce
analyze
methods
tailoring
by
incorporating
active
components,
including
functional
molecules,
2D
metal
ions,
natural
polymers,
drugs/genes.
We
then
discuss
applications
designed
biosensors,
therapy.
hope
that
work
provides
valuable
guidance
inspiration
readers
develop
advanced
Язык: Английский
MXenes in combination therapy: Chemo-photothermal, chemodynamic, and photothermal/photodynamic therapies for cancer treatment and antibacterial applications
FlatChem,
Год журнала:
2025,
Номер
unknown, С. 100849 - 100849
Опубликована: Март 1, 2025
Язык: Английский
Integration of Photodiagnosis and Therapy Guided by Micro/Nanorobots
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Micro/Nanorobots(MNRs)integrated
with
phototherapy
represent
an
emerging
approach
to
cancer
treatment
and
hold
significant
potential
for
addressing
bacterial
infections,
neurological
disorders,
cardiovascular
diseases,
related
conditions.
By
leveraging
micro/nanoscale
motor
systems
in
conjunction
phototherapy,
these
robots
enable
real-time
guidance
monitoring
of
therapeutic
processes,
improving
drug
delivery
precision
efficiency.
This
integration
not
only
enhances
the
effectiveness
but
also
minimizes
damage
surrounding
healthy
tissues.
Nevertheless,
clinical
translation
MNRs-assisted
still
faces
numerous
challenges.
In
this
review,
recent
key
developments
field
are
comprehensively
summarized,
critical
roles
applications
highlighted,
insights
into
future
directions
pathway
toward
large-scale
implementation
provided.
Язык: Английский
Recent Advances in Potential Biomedical Applications of MXene‐Based Hydrogels
Polymers for Advanced Technologies,
Год журнала:
2024,
Номер
35(12)
Опубликована: Ноя. 29, 2024
ABSTRACT
MXene‐based
hydrogels
represent
a
significant
advancement
in
biomedical
material
science,
leveraging
the
unique
properties
of
2D
MXenes
and
versatile
functionality
hydrogels.
This
review
discusses
recent
developments
integration
into
hydrogel
matrices,
focusing
on
their
applications
such
as
wound
healing,
drug
delivery,
antimicrobial
activity,
tissue
engineering,
biosensing.
MXenes,
due
to
remarkable
electrical
conductivity,
mechanical
robustness,
tunable
surface
chemistry,
enhance
properties,
responsiveness
environmental
stimuli.
Specifically,
have
shown
great
promise
accelerating
healing
through
photothermal
effects,
delivering
drugs
controlled
manner,
serving
antibacterial
agents.
Their
also
enables
targeted
cancer
therapies,
including
chemodynamic
facilitated
by
high
conductivity
properties.
Despite
promising
progress,
challenges
ensuring
biocompatibility
optimizing
synthesis
for
large‐scale
production
remain.
aims
provide
comprehensive
overview
current
state
applications,
highlighting
ongoing
advancements
potential
future
directions
these
multifunctional
materials.
Язык: Английский
Isolation of Biomolecules Using MXenes
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 11, 2024
Biomolecule
isolation
is
a
crucial
process
in
diverse
biomedical
and
biochemical
applications,
including
diagnostics,
therapeutics,
research,
manufacturing.
Recently,
MXenes,
novel
class
of
two-dimensional
nanomaterials,
have
emerged
as
promising
adsorbents
for
this
purpose
due
to
their
unique
physicochemical
properties.
These
biocompatible
antibacterial
nanomaterials
feature
high
aspect
ratio,
excellent
conductivity,
versatile
surface
chemistry.
This
timely
review
explores
the
potential
MXenes
isolating
wide
range
biomolecules,
such
proteins,
nucleic
acids,
small
molecules,
while
highlighting
key
future
research
trends
innovative
applications
poised
transform
field.
provides
an
in-depth
discussion
various
synthesis
methods
functionalization
techniques
that
enhance
specificity
efficiency
biomolecule
isolation.
In
addition,
mechanisms
by
which
interact
with
biomolecules
are
elucidated,
offering
insights
into
selective
adsorption
customized
separation
capabilities.
also
addresses
recent
advancements,
identifies
existing
challenges,
examines
emerging
may
drive
next
wave
innovation
rapidly
evolving
area.
Язык: Английский
Bifunctional nanoprobe for simultaneous detection of intracellular reactive oxygen species and temperature in single cells
Microsystems & Nanoengineering,
Год журнала:
2024,
Номер
10(1)
Опубликована: Ноя. 19, 2024
Abstract
Living
cells
can
rapidly
adjust
their
metabolic
activities
in
response
to
external
stimuli,
leading
fluctuations
intracellular
temperature
and
reactive
oxygen
species
(ROS)
levels.
Monitoring
these
parameters
is
essential
for
understanding
cellular
metabolism,
particularly
during
dynamic
biological
processes.
In
this
study,
we
present
a
bifunctional
nanoprobe
capable
of
simultaneous
measurement
ROS
levels
within
single
cells.
The
features
two
individually
addressable
nanoelectrodes,
with
platinum
(Pt)
nickel
(Ni)
coatings
on
both
sides.
At
the
tip,
metal
layers
form
nano-thermocouple,
enabling
precise
measurements,
while
Pt
layer
facilitates
selective
detection.
This
dual
functionality
allows
real-time
monitoring
responses
synergistic
chemo-photothermal
therapy
cancer
zebrafish
embryos
subjected
mitochondrial
toxic
stress.
Our
results
demonstrate
that
effectively
measures
increases
HeLa
undergoing
therapy,
as
well
chemically
stimulated
embryos.
By
providing
detailed
analysis
submicrometer-scale
variations
living
cells,
offers
valuable
insights
into
processes
holds
promise
early
disease
detection
drug
development.
Язык: Английский