Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy DOI Creative Commons

Meijia Huang,

Jie Cui,

Qi Wu

и другие.

Inorganic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

The ability of photosensitizers (PSs) to generate reactive oxygen species (ROS) is crucial for photodynamic therapy (PDT). However, many traditional PSs face the drawbacks that aggregation-caused quenching (ACQ) and highly expressed glutathione (GSH) in tumor microenvironment seriously limit their ROS generation ability. Herein, we report two cationic dinuclear iridium complexes, Ir–C–C–Ir Ir–S–S–Ir, which possess aggregation-induced emission (AIE). Ir–S–S–Ir was constructed GSH consumption by introducing a disulfide linkage between auxiliary ligands with imine units. Quantum chemical calculations revealed degenerate states, provide more channels singlet-to-triplet exciton transitions, then intersystem crossing rate increased due heavy atom effect sulfur atoms. production experiments indicated singlet yield 33 times than ACQ mononuclear complex Ir–C. Most importantly, consumed through thiol–disulfide exchange reaction, as demonstrated mass spectrometry high-performance liquid chromatography. Cell testified consumes cells, possesses good capacity, exhibits an extraordinary PDT effect. This first AIE GSH-consuming function.

Язык: Английский

Two‐Photon Mediated Cancer Therapy: A Comprehensive Review on Two‐Photon Photodynamic Therapy and Two‐Photon‐Activated Therapeutic Delivery Systems DOI
Amir Soleimany, Delaram Kargari Aghmiouni,

Masomeh Amirikhah

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(48)

Опубликована: Июль 18, 2024

Abstract Two‐photon excitation (2PE) represents substantial advantages in biophotonics over traditional one‐photon (1PE), offering enhanced spatial resolution and deeper tissue penetration capabilities. Since its introduction the 1990s, two‐photon excited microscopy has spurred rapid emergence of novel 2PE‐based applications, including photodynamic therapy (PDT) targeted release biologically active agents. This review first elucidates fundamental principles 2PE before comprehensively examining evolution photosensitizers (PSs) for PDT (2P‐PDT), covering both nanomaterials small molecules, categorized based on their respective characteristics. Additionally, it explores advancements PS development integrating 2P‐PDT with other therapeutic modalities (e.g., photothermal therapy, chemotherapy, immunotherapy, gene etc.). Subsequent sections provide an overview photoactivatable compounds absorption properties controlled various agents drugs, genes, gasotransmitters), emphasizing potential anticancer applications. Last, a deep discussion deciphers prospects challenges 2P‐mediated cancer treatment, particularly concerning clinical translation.

Язык: Английский

Процитировано

11
BODIPY-Based Photosensitizer with Outstanding Photocytotoxicity for Deep-Tissue Photodynamic Therapy DOI

Bin‐Kai Liu,

Kun‐Xu Teng, Li‐Ya Niu

и другие.

ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 1947 - 1955

Опубликована: Апрель 19, 2025

Язык: Английский

Процитировано

0
Fiber Optic‐Mediated Type I Photodynamic Therapy of Brain Glioblastoma Based on an Aggregation‐Induced Emission Photosensitizer DOI
Wenguang Zhang,

Miaomiao Kang,

Xue Li

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 30, 2024

Abstract Glioblastoma (GBM) is one of the most lethal human malignancies. The current standard‐of‐care highly invasive with strong toxic side effects, leading to poor prognosis and high mortality. As a safe effective clinical approach, photodynamic therapy (PDT) has emerged as suitable option for GBM. Nevertheless, its implementation significantly impeded by limits light penetration depth firm reliance on oxygen. To overcome these challenges, herein, promising strategy that harnesses modified optical fiber less oxygen‐dependent Type I aggregation‐induced emission (AIE) photosensitizer (PS) developed first time realize in vivo GBM treatments. proposed AIE PS, namely TTTMN, characterized twisted molecular architecture bulky spacer, exhibits enhanced near‐infrared production hydroxyl superoxide radicals at aggregated state, thus affording efficient fluorescence imaging‐guided PDT once formulated into nanoparticles. inhibition orthotopic subcutaneous xenografts provides compelling evidence treatment efficacy irradiated through tumor‐inserted fiber. These findings highlight substantially improved therapeutic outcomes achieved optic‐mediated PDT, positioning it modality

Язык: Английский

Процитировано

2
AIEgen Photosensitizer-Loaded Silica Nanoparticles for Lysosomes-Targeting Photodynamic Therapy in Tumor DOI
Mingyan Zhao, Wenguang Zhang, Miaozhuang Fan

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(20), С. 23504 - 23512

Опубликована: Окт. 10, 2024

Aggregation-induced emission (AIE)-based photosensitizers (PSs) are well-known for their exceptional biocompatibility and high irradiation-induced reactive oxygen species (ROS) generation capacity, making them promising candidates photodynamic therapy (PDT). In antitumor treatment, enhancing the spatiotemporal specificity of AIEgen PSs can maximize efficacy suppressing tumor cells. Lysosomes, as digestive cellular organelles, be perturbed by various external stimuli, leading to dysfunction even apoptosis. This makes ideal targets effective precise PDT. this study, an AIE photosensitizer MEO-TTMN (MT) was encapsulated with a silica shell develop AIE-based nanoparticles (NPs), MT@SiO2-MP NPs, The absorption peaks these NPs were at 513 675 nm, respectively. Upon irradiation, exhibited stronger ROS capacity when compared commercial chlorin e6 (Ce6). decoration morpholine group on surface facilitated accumulate specifically in lysosomes. A level proven situ generated lysosomal sites which led damage lysosomes subsequent apoptosis vivo PDT tumor-bearing mouse demonstrated that significantly suppressed growth tumor. work has provided efficient lysosome-targeting improve accuracy, is beneficial cancer field nanomedicine research.

Язык: Английский

Процитировано

1
An NIR‐II Two‐Photon Excitable AIE Photosensitizer for Precise and Efficient Treatment of Orthotopic Small‐Size Glioblastoma DOI Open Access
Zhourui Xu, Xue Li, Zeng‐Ming Yang

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

The existence of residual small-size tumors after surgery is a major factor contributing to the high recurrence rate glioblastoma (GBM). Conventional adjuvant therapeutics involving both chemotherapy and radiotherapy usually exhibit unsatisfactory efficacy severe side effects. Recently, two-photon photodynamic therapy (TP-PDT), especially excited by second near-infrared (NIR-II) light, offers an unprecedented opportunity address this challenge, attributed its combinational merits PDT TP excitation. However, attempt has not been explored yet. On other hand, lack high-performance photosensitizers (PSs) also hinders progress TP-PDT on GBM. Based those, robust TP-PS, termed MeTTh, constructed intendedly through elaborately integrating multiple beneficial design strategies into single molecule, which simultaneously achieves excellent NIR-II excitation, large absorption cross-section, aggregation-induced NIR-I emission, prominent Type I/II reactive oxygen species generation. Aided nanofabrication, impressive brain structure imaging depth 940 µm realized. Moreover, MeTTh nanoparticles smoothly implement precise efficient treatment GBM in vivo under 1040 nm femtosecond laser irradiation. This study represents first-in-class using GBM, offering new insights for complex vital tissues.

Язык: Английский

Процитировано

1
Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy DOI

Jizhong Shi,

Manshan Liang,

Yi-Ting Qiu

и другие.

Talanta, Год журнала: 2024, Номер 282, С. 127074 - 127074

Опубликована: Окт. 18, 2024

Язык: Английский

Процитировано

0
Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy DOI Creative Commons

Meijia Huang,

Jie Cui,

Qi Wu

и другие.

Inorganic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

The ability of photosensitizers (PSs) to generate reactive oxygen species (ROS) is crucial for photodynamic therapy (PDT). However, many traditional PSs face the drawbacks that aggregation-caused quenching (ACQ) and highly expressed glutathione (GSH) in tumor microenvironment seriously limit their ROS generation ability. Herein, we report two cationic dinuclear iridium complexes, Ir–C–C–Ir Ir–S–S–Ir, which possess aggregation-induced emission (AIE). Ir–S–S–Ir was constructed GSH consumption by introducing a disulfide linkage between auxiliary ligands with imine units. Quantum chemical calculations revealed degenerate states, provide more channels singlet-to-triplet exciton transitions, then intersystem crossing rate increased due heavy atom effect sulfur atoms. production experiments indicated singlet yield 33 times than ACQ mononuclear complex Ir–C. Most importantly, consumed through thiol–disulfide exchange reaction, as demonstrated mass spectrometry high-performance liquid chromatography. Cell testified consumes cells, possesses good capacity, exhibits an extraordinary PDT effect. This first AIE GSH-consuming function.

Язык: Английский

Процитировано

0