Beyond cisplatin: New frontiers in metallodrugs for hard-to-treat triple negative breast cancer

Coordination Chemistry Reviews, Год журнала: 2023, Номер 499, С. 215507 - 215507

Опубликована: Окт. 27, 2023

Язык: Английский

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Bioinspired hot-spot engineering strategy towards ultrasensitive SERS sandwich biosensor for bacterial detection

Biosensors and Bioelectronics, Год журнала: 2023, Номер 237, С. 115497 - 115497

Опубликована: Июнь 24, 2023

Язык: Английский

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Synergistic Functional Nanomedicine Enhances Ferroptosis Therapy for Breast Tumors by a Blocking Defensive Redox System

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(2), С. 2705 - 2713

Опубликована: Янв. 9, 2023

The upregulation of dihydroorotate dehydrogenase (DHODH) redox systems inside tumor cells provides a powerful shelter against lipid peroxidation (LPO), impeding ferroptosis-induced antitumor responses. To solve this issue, we report strategy to block and enhance ferroptotic cancer cell death based on layered double hydroxide (LDH) nanoplatform (siR/IONs@LDH) co-loaded with ferroptosis agent iron oxide nanoparticles (IONs) the DHODH inhibitor (siR). siR/IONs@LDH is able simultaneously release IONs siR in pH-responsive manner, efficiently generate toxic reactive oxygen species (ROS) via an Fe2+-mediated Fenton reaction, synergistically induce upon acceleration LPO accumulation. In vivo therapeutic evaluations demonstrate that nanomedicine has excellent performance for growth inhibition without any detectable side effects. This work thus new insight into nanomaterial-mediated therapy.

Язык: Английский

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A bright future: Advanced nanotechnology-assisted microwave therapy

Nano Today, Год журнала: 2023, Номер 52, С. 101963 - 101963

Опубликована: Авг. 12, 2023

Язык: Английский

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Engineering a synergistic antioxidant inhibition nanoplatform to enhance oxidative damage in tumor treatment

Acta Biomaterialia, Год журнала: 2023, Номер 158, С. 625 - 636

Опубликована: Янв. 4, 2023

Язык: Английский

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